Disease/Experimental Model

Effects of extended-release buprenorphine on mouse models of influenza

Mice are widely used as small animal models for influenza infection and immunization studies because of their susceptibility to many strains of influenza, obvious clinical signs of infection, and ease of handling. Analgesia is rarely used in such studies even...

Year Published: 2023Topics: Analgesia, Disease/Experimental ModelAnimal Type: Mouse, Rodent

Citation: Brake, M. E., Russ, B. P., Gansebom, S. et al. 2023. Effects of extended-release buprenorphine on mouse models of influenza. Comparative Medicine 73(6), 466–473.

Which form of environmental enrichment is most effective in rodent models of autism?

Environmental enrichment (EE) is known to produce experience-dependent changes in the brains and behaviors of rodents, and it has therefore been widely used to study neurodevelopmental disorders, including autism. Current studies show significant protocol variation, such as the presence of...

Year Published: 2023Topics: Disease/Experimental Model, Environmental EnrichmentAnimal Type: Mouse, Rat, Rodent

Citation: Caires, C. R. S., Bossolani-Martins, A. L. 2023. Which form of environmental enrichment is most effective in rodent models of autism? Behavioural Processes 211, 104915.

A novel scoring system for humane endpoints in mice with cecal ligation and puncture-induced sepsis

Animal-based research is essential to the study of sepsis pathophysiology, diagnostics, and therapeutics. However, animal models of sepsis are often associated with high mortality because of the difficulty in predicting imminent death based on premortem assessment of the animals. The...

Year Published: 2023Topics: Disease/Experimental Model, Humane EndpointAnimal Type: Mouse, Rodent

Citation: Ferguson, L. T., Rashied, A. A., Liang, Z. et al. 2023. A novel scoring system for humane endpoints in mice with cecal ligation and puncture-induced sepsis. Comparative Medicine 73(6), 446–460.

Plasma metabolomics supports non-fasted sampling for metabolic profiling across a spectrum of glucose tolerance in the Nile rat model for type 2 diabetes

Type 2 diabetes is a challenge in modern healthcare, and animal models are necessary to identify underlying mechanisms. The Nile rat (Arvicanthis niloticus) develops diet-induced diabetes rapidly on a conventional rodent chow diet without genetic or chemical manipulation. Unlike common...

Year Published: 2023Topics: Biological Sampling & Physiological Measurement, Disease/Experimental ModelAnimal Type: Rat, Rodent

Citation: Anderson, B. J., Curtis, A. M., Jen, A. et al. 2023. Plasma metabolomics supports non-fasted sampling for metabolic profiling across a spectrum of glucose tolerance in the Nile rat model for type 2 diabetes. Lab Animal 52(11), 269–277.

A novel dental caries model replacing, refining, and reducing animal sacrifice

In vitro and in vivo models simulating the dental caries process enable the evaluation of anti-caries modalities for prevention and treatment. Animal experimentation remains important for improving human and animal health. Nonetheless, reducing animal sacrifice for research is desirable. The...

Year Published: 2021Topics: Disease/Experimental ModelAnimal Type: Mouse, Rodent

Citation: Wolfoviz-Zilberman, A., Houri-Haddad, Y., Beyth, N. 2021. A novel dental caries model replacing, refining, and reducing animal sacrifice. Applied Sciences 11(15), 7141.

Refinement of the motorised laminectomy-assisted rat spinal cord injury model by analgesic treatment

Usage and reporting of analgesia in animal models of spinal cord injury (SCI) have been sparse and requires proper attention. The majority of experimental SCI research uses rats as an animal model. This study aimed to probe into the effects...

Year Published: 2024Topics: Disease/Experimental ModelAnimal Type: Rat, Rodent

Citation: Sreelatha, H. V., Palekkodan, H., Fasaludeen, A. et al. 2024. Refinement of the motorised laminectomy-assisted rat spinal cord injury model by analgesic treatment. PLOS ONE 19(1), e0294720.

Rehoming and other refinements and replacement in procedures using golden hamsters in SARS-CoV-2 vaccine research

Effective vaccines are needed to fight the COVID-19 pandemic. Forty golden hamsters were inoculated with two promising vaccine candidates and eighteen animals were used in pilot trials with viral challenge. ELISA assays were performed to determine endpoint serum titres for...

Year Published: 2023Topics: Disease/Experimental ModelAnimal Type: Hamster, Rodent

Citation: Štrbenc, M., Kuhar, U., Lainšček, D. et al. 2023. Rehoming and other refinements and replacement in procedures using golden hamsters in SARS-CoV-2 vaccine research. Animals 13(16), 2616.

The 3Rs in experimental liver disease

Patients with cirrhosis present multiple physiological and immunological alterations that play a very important role in the development of clinically relevant secondary complications to the disease. Experimentation in animal models is essential to understand the pathogenesis of human diseases and,...

Year Published: 2023Topics: Disease/Experimental ModelAnimal Type: All/General, Mouse, Rat, Rodent

Citation: Martinez-Lopez, S., Angel-Gomis, E., Sanchez-Ardid, E. et al. 2023. The 3Rs in experimental liver disease. Animals 13(14), 2357.

Translational echocardiography: The dog as a clinical research model of cardiac dysfunction

Heart disease is a major contributor to mortality and disability on a global scale. Hence, there is a need for research to improve non-invasive diagnostic techniques. Diseases in dogs with characteristics very similar to those of human pathologies hold promise...

Year Published: 2023Topics: Disease/Experimental ModelAnimal Type: Dog

Citation: Flores Dueñas, C. A., Cordero Yañez, I. A., González, R. M. et al. 2023. Translational echocardiography: The dog as a clinical research model of cardiac dysfunction. Applied Sciences 13(7), 4437.

Post-mortem extracorporeal membrane oxygenation perfusion rat model: A feasibility study

The development of biomedical soft- or hardware frequently includes testing in animals. However, large efforts have been made to reduce the number of animal experiments, according to the 3Rs principle. Simultaneously, a significant number of surplus animals are euthanized without...

Year Published: 2023Topics: Disease/Experimental ModelAnimal Type: Rat, Rodent

Citation: Deininger, M. M., Benner, C.-F., Strudthoff, L. J. et al. 2023. Post-mortem extracorporeal membrane oxygenation perfusion rat model: A feasibility study. Animals 13(22), 3532.