Analgesia

Comparison of analgesic efficacy between intrafunicular and intratesticular lidocaine injection in dogs

Elective surgical orchiectomy is a commonly performed procedure in dogs that requires adequate pain management. Multiple studies have shown that various local anaesthetic techniques improve analgesia and may reduce side effects associated with systemically administered drugs. This study aimed to...

Year Published: 2026Topics: AnalgesiaAnimal Type: Dog

Citation: Lohinger, C., Verdier, N., Klonner, M. E. et al. 2026. Comparison of analgesic efficacy between intrafunicular and intratesticular lidocaine injection in dogs. Frontiers in Veterinary Science 13.

Analgesic efficacy of oral tramadol–dipyrone combination in cats undergoing ovariohysterectomy

Introduction Selecting an appropriate analgesic for cats can be challenging due to potential unwanted side effects, short duration of action, or unsuitable presentation for home administration. This study aimed to evaluate the analgesic efficacy and safety of a fixed-dose oral...

Year Published: 2026Topics: AnalgesiaAnimal Type: Cat

Citation: Fantoni, D. T., Yazbek, K. V. B., de Lima, I. T. et al. 2026. Analgesic efficacy of oral tramadol–dipyrone combination in cats undergoing ovariohysterectomy. Frontiers in Veterinary Science 13.

When pain outlasts our drugs: The case for sustained-release analgesia in sheep

Pain associated with routine husbandry procedures in sheep can persist for several days or even weeks, yet current analgesic options, such as the non-steroidal anti-inflammatory drug (NSAID) meloxicam, typically provide only 24–36 h of analgesia. This mismatch between pain duration...

Year Published: 2026Topics: AnalgesiaAnimal Type: Sheep

Citation: Baygi, M. N., Metcalf, L. N., Kimble, B. et al. 2026. When pain outlasts our drugs: The case for sustained-release analgesia in sheep. Animals 16(3).

A review of strain and sex differences in response to pain and analgesia in mice

Pain and its alleviation are currently a highly studied issue in human health. Research on pain and response to analgesia has evolved to include the effects of genetics, heritability, and sex as important components in both humans and animals. The...

Year Published: 2020Topics: Analgesia, Welfare AssessmentAnimal Type: Mouse, Rodent

Citation: Smith J. C. 2019. A review of strain and sex differences in response to pain and analgesia in mice. Comparative Medicine 69(6), 490–500.

Use of flavored tablets of gabapentin and carprofen to attenuate postoperative hypersensitivity in an incisional pain model in rats (Rattus norvegicus)

Providing postoperative analgesia to rats by oral administration, compared with injections, reduces stress from frequent handling and is technically easier for investigators. The purpose of this study was to investigate whether bacon-flavored tablets containing gabapentin, carprofen or a combination of...

Year Published: 2020Topics: Analgesia, Disease/Experimental ModelAnimal Type: Rat, Rodent

Citation: Zude, B. P., Jampachaisri, K., Pacharinsak, C. 2020. Use of flavored tablets of gabapentin and carprofen to attenuate postoperative hypersensitivity in an incisional pain model in rats (Rattus norvegicus). JAALAS 59(2), 163–169.

Defining and managing pain in stroke and traumatic brain injury research

Neurologic conditions such as stroke and traumatic brain injury are challenging conditions to study in humans. Animal models are necessary to uncover disease processes and develop novel therapies. When attempting to model these or other neurologic diseases, the accompanying anesthesia...

Year Published: 2020Topics: Analgesia, Anesthesia & Sedation, Disease/Experimental ModelAnimal Type: All/General

Citation: Larson, C. M., Wilcox, G. L., Fairbanks, C. A. 2019. Defining and managing pain in stroke and traumatic brain injury research. Comparative Medicine 69(6), 510–519.

An Anglocentric history of anaesthetics and analgesics in the refinement of animal experiments

Previous histories of animal experimentation, e.g., Franco (2013) have focused on ethics, the law and the personalities involved, but not on the involvement of anaesthetics or analgesics. Given that these were major subjects of (UK) Parliamentary debates on vivisection in...

Year Published: 2020Topics: Analgesia, Anesthesia & SedationAnimal Type: All/General

Citation: Clutton, R. E. 2020. An Anglocentric history of anaesthetics and analgesics in the refinement of animal experiments. Animals 10(10), 1933.

Clinical management of pain in rodents

The use of effective regimens for mitigating pain remain underutilized in research rodents despite the general acceptance of both the ethical imperative and regulatory requirements intended to maximize animal welfare. Factors contributing to this gap between the need for and...

Year Published: 2020Topics: AnalgesiaAnimal Type: Guinea Pig, Mouse, Rat, Rodent

Citation: Foley, P. L., Kendall, L. V., Turner, P. V. 2019. Clinical management of pain in rodents. Comparative Medicine 69(6), 468–489.

Combination of ketamine and xylazine with opioids and acepromazine in rats: Physiological changes and their analgesic effect analysed by ultrasonic vocalization

In this study, the effect of four anaesthetic protocols that included the combination of xylazine (X) and ketamine (K) with acepromazine (A) and opioids (methadone (Me), morphine (Mo) or tramadol (T)) was evaluated in laboratory rats of both sexes. Ultrasonic...

Year Published: 2020Topics: Analgesia, Anesthesia & SedationAnimal Type: Rat, Rodent

Citation: Alemán-Laporte, J., Bandini, L. A., Garcia-Gomes, M. S. et al. 2020. Combination of ketamine and xylazine with opioids and acepromazine in rats: Physiological changes and their analgesic effect analysed by ultrasonic vocalization. Laboratory Animals 54(2), 171–182.

Preliminary findings on a novel behavioural approach for the assessment of pain and analgesia in lambs subject to routine husbandry procedures

The identification and assessment of pain in sheep under field conditions are important, but, due to their stoic nature, are fraught with many challenges. In Australia, various husbandry procedures that are documented to cause pain are routinely performed at lamb...

Year Published: 2020Topics: Analgesia, Body Modification/Mutilation, Welfare AssessmentAnimal Type: Sheep

Citation: Grant, E. P., Wickham, S. L., Anderson, F. et al. 2020. Preliminary findings on a novel behavioural approach for the assessment of pain and analgesia in lambs subject to routine husbandry procedures. Animals 10(7), 1148.