Analgesia

The analgesic effect of two different extended-release meloxicam formulations for attenuation of hypersensitivity in rats (Rattus norvegicus)

Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID) frequently administered every 24 hours to control mild to moderate pain in rodents. Extended-release meloxicam offers a refinement of less frequent dosing and an extended therapeutic window compared with the standard daily-dosed meloxicam...

Year Published: 2026Topics: AnalgesiaAnimal Type: Rat, Rodent

Citation: Ge, Y., Alamaw, E. D., Jampachaisri, K. et al. 2026. The analgesic effect of two different extended-release meloxicam formulations for attenuation of hypersensitivity in rats (Rattus norvegicus). JAALAS 65(1), 58–64.

AnaesthesiaSkills in Veterinary Medicine: Perioperative Management in Small, Companion and Domestic Animals

This book is designed as a practice-orientated text covering monitoring and equipment, established protocols, pain management, complications and underlying disease. The strength of the book is the inclusion of a relatively wide spectrum of species – dogs, cats, rabbits, ferrets,...

Year Published: 2024Topics: Analgesia, Anesthesia & SedationAnimal Type: Cat, Cattle, Dog, Equine, Ferret, Gerbil, Goat, Guinea Pig, Hamster, Mouse, Pig, Rabbit, Rat, Rodent

Citation: Eberspächer-Schweda, E. 2024. AnaesthesiaSkills in Veterinary Medicine: Perioperative Management in Small, Companion and Domestic Animals. Thieme Medical Publishers, Inc, 512 pp.

Assessing local anesthesia in Octopus bimaculoides to provide analgesia

Despite the substantial growth of cephalopod research over the past 15 years, effective pain management for these animals remains largely unstudied, and no US federal regulations currently address cephalopod analgesia. This 2-phase study evaluated the feasibility and efficacy of lidocaine,...

Year Published: 2026Topics: Analgesia, Anesthesia & SedationAnimal Type: Cephalopod, Invertebrate

Citation: Copio, J. N., Schulz, N. G., Ragsdale, C. W. et al. 2026. Assessing local anesthesia in Octopus bimaculoides to provide analgesia. JAALAS 65(2), 171–181.

Subcutaneous buprenorphine is an acceptable preoperative analgesic in pregnant ewes undergoing hysterotomy (Ovis aries)

Methodological status quo is often closely guarded in animal research because changes are seen as a threat to approaches that have proven successful. Current practices are often considered within the group as “best practice.” Perioperative analgesia is an important consideration...

Year Published: 2025Topics: AnalgesiaAnimal Type: Sheep

Citation: Alaniz, S. M., Louey, S., Minnier, J. et al. 2025. Subcutaneous buprenorphine is an acceptable preoperative analgesic in pregnant ewes undergoing hysterotomy (Ovis aries). JAALAS 64(6), 1112–1120.

Comparison of analgesic efficacy between intrafunicular and intratesticular lidocaine injection in dogs

Elective surgical orchiectomy is a commonly performed procedure in dogs that requires adequate pain management. Multiple studies have shown that various local anaesthetic techniques improve analgesia and may reduce side effects associated with systemically administered drugs. This study aimed to...

Year Published: 2026Topics: AnalgesiaAnimal Type: Dog

Citation: Lohinger, C., Verdier, N., Klonner, M. E. et al. 2026. Comparison of analgesic efficacy between intrafunicular and intratesticular lidocaine injection in dogs. Frontiers in Veterinary Science 13.

Analgesic efficacy of oral tramadol–dipyrone combination in cats undergoing ovariohysterectomy

Introduction Selecting an appropriate analgesic for cats can be challenging due to potential unwanted side effects, short duration of action, or unsuitable presentation for home administration. This study aimed to evaluate the analgesic efficacy and safety of a fixed-dose oral...

Year Published: 2026Topics: AnalgesiaAnimal Type: Cat

Citation: Fantoni, D. T., Yazbek, K. V. B., de Lima, I. T. et al. 2026. Analgesic efficacy of oral tramadol–dipyrone combination in cats undergoing ovariohysterectomy. Frontiers in Veterinary Science 13.

When pain outlasts our drugs: The case for sustained-release analgesia in sheep

Pain associated with routine husbandry procedures in sheep can persist for several days or even weeks, yet current analgesic options, such as the non-steroidal anti-inflammatory drug (NSAID) meloxicam, typically provide only 24–36 h of analgesia. This mismatch between pain duration...

Year Published: 2026Topics: AnalgesiaAnimal Type: Sheep

Citation: Baygi, M. N., Metcalf, L. N., Kimble, B. et al. 2026. When pain outlasts our drugs: The case for sustained-release analgesia in sheep. Animals 16(3).

A review of strain and sex differences in response to pain and analgesia in mice

Pain and its alleviation are currently a highly studied issue in human health. Research on pain and response to analgesia has evolved to include the effects of genetics, heritability, and sex as important components in both humans and animals. The...

Year Published: 2020Topics: Analgesia, Welfare AssessmentAnimal Type: Mouse, Rodent

Citation: Smith J. C. 2019. A review of strain and sex differences in response to pain and analgesia in mice. Comparative Medicine 69(6), 490–500.

Use of flavored tablets of gabapentin and carprofen to attenuate postoperative hypersensitivity in an incisional pain model in rats (Rattus norvegicus)

Providing postoperative analgesia to rats by oral administration, compared with injections, reduces stress from frequent handling and is technically easier for investigators. The purpose of this study was to investigate whether bacon-flavored tablets containing gabapentin, carprofen or a combination of...

Year Published: 2020Topics: Analgesia, Disease/Experimental ModelAnimal Type: Rat, Rodent

Citation: Zude, B. P., Jampachaisri, K., Pacharinsak, C. 2020. Use of flavored tablets of gabapentin and carprofen to attenuate postoperative hypersensitivity in an incisional pain model in rats (Rattus norvegicus). JAALAS 59(2), 163–169.

Defining and managing pain in stroke and traumatic brain injury research

Neurologic conditions such as stroke and traumatic brain injury are challenging conditions to study in humans. Animal models are necessary to uncover disease processes and develop novel therapies. When attempting to model these or other neurologic diseases, the accompanying anesthesia...

Year Published: 2020Topics: Analgesia, Anesthesia & Sedation, Disease/Experimental ModelAnimal Type: All/General

Citation: Larson, C. M., Wilcox, G. L., Fairbanks, C. A. 2019. Defining and managing pain in stroke and traumatic brain injury research. Comparative Medicine 69(6), 510–519.