Anesthesia & Sedation

Optimization of ketamine/xylazine anesthesia in geriatric mice

Aged mice are becoming increasingly important models for human senescence. Many studies require anesthesia. Standard rodent ketamine/xylazine injectable regimens have been associated with increased incidences of death, unreliable surgical planes, and prolonged recoveries in geriatric mice. We hypothesized that the...

Year Published: 2025Topics: Anesthesia & SedationAnimal Type: Mouse, Rodent

Citation: Beecy, S., Meuse, D., Kizielewicz, N. et al. 2025. Optimization of ketamine/xylazine anesthesia in geriatric mice. JAALAS 64(4), 778–787.

Comparison of dexmedetomidine/morphine and xylazine/morphine as premedication in isoflurane-anesthetized sheep

In this study we investigated the sedative, anesthetic, and pulmonary histopathologic effects of dexmedetomidine/morphine (DM) and xylazine/morphine (XM) in sheep. We hypothesized that DM would provide profound sedation and better maintain physiologic parameters under anesthesia than XM in sheep undergoing...

Year Published: 2025Topics: Anesthesia & SedationAnimal Type: Sheep

Citation: Akaraphutiporn, E., Bunnag, P., Limprasutr, V. et al. 2025. Comparison of dexmedetomidine/morphine and xylazine/morphine as premedication in isoflurane-anesthetized sheep. JAALAS 64(4), 726–732.

Impact of sequential administration of detomidine, butorphanol, and midazolam on sedation, ataxia, stimulus response, and bispectral index in horses

Background Standing sedation is a safe and cost-effective alternative to general anesthesia in horses, but challenges include achieving adequate drug effect to block the stimulus response without inducing ataxia or recumbency. A benefit of midazolam has been reported in equine...

Year Published: 2025Topics: Anesthesia & SedationAnimal Type: Equine

Citation: Thorn, C. A., Wilson, D. V., Wang, S. et al. 2025. Impact of sequential administration of detomidine, butorphanol, and midazolam on sedation, ataxia, stimulus response, and bispectral index in horses. Frontiers in Veterinary Science 12.

Optimizing equine standing sedation: Continuous infusion of detomidine and butorphanol enhances stability but prolongs ataxia

ObjectiveThis study aimed to compare the sedation quality and cardiorespiratory and behavioral effects of detomidine administered intravenously, either in intermittent boluses or as a continuous rate infusion, with butorphanol in horses pre-medicated with acepromazine for odontoplasty procedures.MethodsA prospective clinical study...

Year Published: 2025Topics: Anesthesia & SedationAnimal Type: Equine

Citation: Arantes, J. de A., Rabelo, I. P., Bermudes, L. et al. 2025. Optimizing equine standing sedation: Continuous infusion of detomidine and butorphanol enhances stability but prolongs ataxia. Frontiers in Veterinary Science 12.

Contactless monitoring of respiratory rate variability in rats under anesthesia with a compact 24GHz microwave radar sensor (2025)

Objective The objective of this study was to develop and validate a noncontact monitoring system for respiratory rate variability in rats under anesthesia using a 24GHz microwave radar sensor. This study aimed to address the need for stress-free monitoring techniques...

Year Published: 2025Topics: Anesthesia & Sedation, Biological Sampling & Physiological MeasurementAnimal Type: Rat, Rodent

Citation: Sun, G., Kurosawa, M., Ninomiya, Y. et al. 2025. Contactless monitoring of respiratory rate variability in rats under anesthesia with a compact 24GHz microwave radar sensor. Frontiers in Veterinary Science 12.

Evaluation of different intramuscular injectable anesthetic combinations in rabbits: Impact on anesthetic depth, physiological parameters, and EEG recordings (2025)

Rabbits have a high anesthesia-related mortality rate because of their small size, high metabolic rate and challenging airway management. This study aimed to investigate different combinations of intramuscularly administered anesthetics in New Zealand White rabbits, focusing on their effects on...

Year Published: 2025Topics: Anesthesia & Sedation, Surgery & Post-OpAnimal Type: Rabbit

Citation: Schmid, M.-L., Werner, J., Saller, A. M. et al. 2025. Evaluation of different intramuscular injectable anesthetic combinations in rabbits: Impact on anesthetic depth, physiological parameters, and EEG recordings. PLOS ONE 20(2), e0319106.

Tricaine, eugenol and etomidate for repetitive procedural anesthesia in adult zebrafish, Danio rerio: Effect on stress and behavior (2025)

Zebrafish has emerged as a popular animal model in biomedical research. Numerous procedures and interventions require occasionally repetitive anesthesia. Tricaine is the most frequently used anesthetic for zebrafish and its efficacy is well established. However, the safety and efficacy of...

Year Published: 2025Topics: Anesthesia & SedationAnimal Type: Fish, Zebrafish

Citation: Narumanchi, S., Perttunen, S., Laine, P. et al. 2025. Tricaine, eugenol and etomidate for repetitive procedural anesthesia in adult zebrafish, Danio rerio: Effect on stress and behavior. Frontiers in Veterinary Science 12.

Acute effect of short-term benzocaine anesthesia on the skin mucus microbiome of Atlantic salmon (Salmo salar)

Routine aquaculture practices such as capture, transportation, and handling can disrupt the relationship between commensal and opportunistic bacteria in the fish skin microbiome. Anesthetic baths are a common welfare practice in aquaculture to reduce stress during handling. However, to date,...

Year Published: 2025Topics: Anesthesia & SedationAnimal Type: Fish, Salmon

Citation: Martins, P., Pimentel, T., Ribeiro, N. et al. 2025. Acute effect of short-term benzocaine anesthesia on the skin mucus microbiome of Atlantic salmon (Salmo salar). Animals 15(11), 1566.

Welfare implications of low-dose atipamezole reversal of tiletamine/zolazepam/xylazine anaesthesia in pigs (2025)

Anaesthesia is sometimes required for the effective restraint of laboratory pigs for sample collection. Yet, anaesthesia can initiate a range of physiological disruptions that can increase variability in study data and lead to poorer animal welfare. Judicious use of anaesthesia...

Year Published: 2025Topics: Anesthesia & SedationAnimal Type: Pig

Citation: Layton, R., Beggs, D. S., Fisher, A. et al. 2025. Welfare implications of low-dose atipamezole reversal of tiletamine/zolazepam/xylazine anaesthesia in pigs. Animals 15(2), 258.

Evaluation of tricaine methanesulfonate concentrations for flow anesthesia in zebrafish (Danio rerio) (2025)

Zebrafish (Danio rerio) are often anesthetized by immersion in buffered tricaine methanesulfonate (MS-222). Although commonly utilized, immersion anesthesia presents a shortcoming of lethal asphyxiation with increased duration of exposures. A newer technique that circumvents this issue, known as flow anesthesia,...

Year Published: 2025Topics: Anesthesia & SedationAnimal Type: Fish, Zebrafish

Citation: Kramer, A. G., Bern, L. R., Ferguson, L. T. et al. 2025. Evaluation of tricaine methanesulfonate concentrations for flow anesthesia in zebrafish (Danio rerio). Zebrafish 22(3), 99–106.