Humane Endpoint

Opportunities for refinement of non-human primate vaccine studies

Non-human primates (NHPs) are used extensively in the development of vaccines and therapeutics for human disease. High standards in the design, conduct, and reporting of NHP vaccine studies are crucial for maximizing their scientific value and translation, and for making...

Year Published: 2021Topics: Disease/Experimental Model, Environmental Enrichment, Housing, Humane Endpoint, Husbandry & Management, Social Housing & CompanionshipAnimal Type: Baboon, Capuchin, Macaque, Marmoset, Nonhuman Primate, Vervet (African Green Monkey)

Citation: Prescott, M. J., Clark, C., Dowling, W. E. et al. 2021. Opportunities for refinement of non-human primate vaccine studies. Vaccines 9(3), 284.

The edge of lesion

At AstraZeneca we utilise a wide variety of flank tumour models in rodents to gather data on the effectiveness of our Oncology drugs. During these studies tumour condition is closely monitored for appearance of lesions; typically a change of shape...

Year Published: 2025Topics: Humane EndpointAnimal Type: Rat, Rodent

Citation: Little, E., Baker, T., Peverill, J. et al. 2025. The edge of lesion. Animal Technology and Welfare 24(3), 268–269.

A rational approach of early humane endpoint determination in a murine model for cholestasis

Reduction of animal suffering during in vivo experiments is usually ensured by continuously monitoring the health status using a score sheet and by applying humane endpoints. However, most studies do not evaluate the plausibility of score sheets and do not...

Year Published: 2020Topics: Disease/Experimental Model, Humane EndpointAnimal Type: Mouse, Rodent

Citation: Zhang, X., Kumstel, S., Tang, G. et al. 2020. A rational approach of early humane endpoint determination in a murine model for cholestasis. ALTEX 37(2), 197-207.

Body weight algorithm predicts humane endpoint in an intracranial rat glioma model

Humane endpoint determination is fundamental in animal experimentation. Despite commonly accepted endpoint criteria for intracranial tumour models (20% body weight loss and deteriorated clinical score) some animals still die before being euthanized in current research. We here systematically evaluated other...

Year Published: 2020Topics: Disease/Experimental Model, Humane EndpointAnimal Type: Rat, Rodent

Citation: Helgers, S., Talbot, S. R., Riedesel, A. K. et al. 2020. Body weight algorithm predicts humane endpoint in an intracranial rat glioma model. Scientific Reports 10, 9020.

Defining body-weight reduction as a humane endpoint: A critical appraisal

In many animal experiments scientists and local authorities define a body-weight reduction of 20% or more as severe suffering and thereby as a potential parameter for humane endpoint decisions. In this study, we evaluated distinct animal experiments in multiple research...

Year Published: 2020Topics: Disease/Experimental Model, Humane Endpoint, Welfare AssessmentAnimal Type: Mouse, Rat, Rodent

Citation: Talbot, S. R., Biernot, S., Bleich, A. et al. 2020. Defining body-weight reduction as a humane endpoint: A critical appraisal. Laboratory Animals 54(1), 99–110.

Endpoint in ovarian cancer xenograft model predicted by nighttime motion metrics

Despite several therapeutics showing promise in nonclinical studies, survival from ovarian cancer remains poor. New technologies are urgently needed to optimize the translation of nonclinical studies into clinical successes. While most nonclinical settings utilize subjective measures of physiological parameters, which...

Year Published: 2020Topics: Disease/Experimental Model, Humane EndpointAnimal Type: Mouse, Rodent

Citation: Nwagwu, C. D., Defensor, E., Jiang, M. Y. et al. 2020. Endpoint in ovarian cancer xenograft model predicted by nighttime motion metrics. Lab Animal 49(8), 227–232.

Humane endpoints in severe irradiation experiments using non-human primates: A retrospective analysis

A retrospective statistical study has been performed in order to identify the biological, clinical and behavioural variables that could potentially predict the survival status of irradiated non-human primates (NHP) and to refine the future use of humane endpoints (HEP). The...

Year Published: 2020Topics: Disease/Experimental Model, Humane EndpointAnimal Type: Macaque, Nonhuman Primate

Citation: Bertho, J.-M., Ancelet, S., Denais-Laliève, D. et al. 2020. Humane endpoints in severe irradiation experiments using non-human primates: A retrospective analysis. Scandinavian Journal of Laboratory Animal Science 46(1).

Progressing the care, husbandry and management of ageing mice used in scientific studies

Driven by the longer lifespans of humans, particularly in Westernised societies, and the need to know more about ‘healthy ageing’, ageing mice are being used increasingly in scientific research. Many departments and institutes involved with ageing research have developed their...

Year Published: 2020Topics: Disease/Experimental Model, Humane Endpoint, Welfare AssessmentAnimal Type: Mouse, Rodent

Citation: Wilkinson, M. J. A., Selman, C., McLaughlin, L. et al. 2020. Progressing the care, husbandry and management of ageing mice used in scientific studies. Laboratory Animals 54(3) 225–238.

Contactless body temperature assessment for signalling humane endpoints in a mouse model of sepsis

Minimising suffering is an ethical and legal requirement in animal research. This is particularly relevant for research on animal models of sepsis and septic shock, which show rapid progression towards severe stages and death. Specific and reliable criteria signalling non-recovery...

Year Published: 2025Topics: Disease/Experimental Model, Humane EndpointAnimal Type: Mouse, Rodent

Citation: Miranda, C., Oliveira, L., Carmo, A. M. et al. 2025. Contactless body temperature assessment for signalling humane endpoints in a mouse model of sepsis. Animal Welfare 34, e13.

Phenotypical, behavioral, and systemic hallmarks in end-point mouse scenarios (2025)

The state of frailty is a clinical–biological syndrome that affects the older population with a higher risk of functional dependence. Animal models can provide a tool to study this complex scenario. In the present work, we analyzed the physical and...

Year Published: 2025Topics: Humane EndpointAnimal Type: Mouse, Rodent

Citation: Castillo-Mariqueo, L., Alveal-Mellado, D., Giménez-Llort, L. 2025. Phenotypical, Behavioral, and Systemic Hallmarks in End-Point Mouse Scenarios. Animals 15(4), 521.