Drug/Substance Administration

Report of the 2024 RSPCA/UFAW rodent welfare group meeting

The RSPCA/UFAW Rodent Welfare Group has held a one-day meeting every autumn for the last 31 years. These meetings provide an opportunity for members to discuss current welfare research, exchange views on welfare issues and share their experiences of the...

Year Published: 2025Topics: Animal Training, Drug/Substance Administration, Environmental Enrichment, Handling, Housing, Husbandry & Management, Imaging & Electrophysiological RecordingAnimal Type: Mouse, Rabbit, Rat, Rodent

Citation: Stevens, C., Robinson, E., Jackson, M. et al. 2025. Report of the 2024 RSPCA/UFAW rodent welfare group meeting. Animal Welfare and Technology 4(3), 219–226.

Small changes, big differences: Collaborative refinements in animal research

Our unit opened in 2017, during the procurement of new equipment we had the opportunity to purchase a digital ventilated rack system from Tecniplast UK. The cages are referred to as the Digitally Ventilated Cage or DVC. This system uses...

Year Published: 2025Topics: Drug/Substance Administration, Surgery & Post-OpAnimal Type: Mouse, Rabbit, Rodent

Citation: Onions, L., WIlkinson, G. 2025. Small changes, big differences: Collaborative refinements in animal research. Animal Technology and Welfare 24(3), 239–240.

Exploring the impact of acute solvent exposure on larval zebrafish behaviour

Zebrafish (Danio rerio) are commonly used to test the impact of pharmacological and toxicological compounds. Larval zebrafish are extensively used because of high throughput procedures allowing simultaneous behavioural measurement in 24-, 48-, or 96-well plates. Often solvents are used as...

Year Published: 2025Topics: Drug/Substance AdministrationAnimal Type: Fish, Zebrafish

Citation: Hagen, E. V., Harper, M. M. M., Zhang, Y. et al. 2025. Exploring the impact of acute solvent exposure on larval zebrafish behaviour. Frontiers in Behavioral Neuroscience 19.

The cotton rat – a new challenge

This poster describes how the Animal Technologists at Envigo adapted their current practices and procedures for a new species at their laboratory: the cotton rat. The paper describes cotton rat biology and behaviour; housing; environmental enrichment; health; dosing and blood...

Year Published: 2020Topics: Anesthesia & Sedation, Biological Sampling & Physiological Measurement, Drug/Substance Administration, Environmental Enrichment, Euthanasia, Housing, Husbandry & Management, Natural BehaviorAnimal Type: Rat, Rodent

Citation: Ballantine, A., Rodgers, D., Watts, C. et al. 2020. The cotton rat – a new challenge. Animal Technology and Welfare 19(1), 92-95.

Gastrostomy tube placement via a laparotomic procedure in growing conventional piglets to perform multidose preclinical paediatric drug studies

The use of juvenile conventional pigs as a preclinical animal model to perform pharmacokinetic (PK), pharmacodynamic (PD) and safety studies for the paediatric population is increasing. Repetitive oral administration of drugs to juvenile pigs is however challenging. A representative method...

Year Published: 2020Topics: Drug/Substance AdministrationAnimal Type: Pig

Citation: Millecam, J., van Bergen, T., Devreese, M. 2020. Gastrostomy tube placement via a laparotomic procedure in growing conventional piglets to perform multidose preclinical paediatric drug studies. Laboratory Animals 54(3), 261-271.

It’s Okay to Cry – Discussions by the Laboratory Animal Refinement & Enrichment Forum [LAREF], Volume V

This is the 5th volume of selected discussions that took place on the electronic Laboratory Animal Refinement & Enrichment Forum between February 2016 and December 2019. The forum was created in October 2002; it allows the international animal care community...

Year Published: 2020Topics: Abnormal/Problematic Behavior, Animal Training, Biological Sampling & Physiological Measurement, Drug/Substance Administration, Environmental Enrichment, External Bodily Equipment, Housing, Human-Animal Interaction, Relocation & TransportAnimal Type: Cat, Chinchilla, Dog, Ferret, Guinea Pig, Macaque, Marmoset, Mouse, Nonhuman Primate, Pig, Rabbit, Rat, Rodent

Citation: Reinhardt, V. (ed.) 2020. It’s Okay to Cry - Discussions by the Laboratory Animal Refinement & Enrichment Forum [LAREF], Volume V. Animal Welfare Institute, Washington, DC.

Sex and strain differences in the micropipette-guided drug administration (MDA) method in mice

To provide an alternative to oral gavage for per os treatments in laboratory mice, we have recently developed and introduced the micropipette-guided drug administration (MDA) method. This procedure is based on the presentation of a palatable solution consisting of sweetened...

Year Published: 2025Topics: Drug/Substance AdministrationAnimal Type: Mouse, Rodent

Citation: Steiner, S., Krzyzaniak, O., Nilsson, F. A. M. et al. 2025. Sex and strain differences in the micropipette-guided drug administration (MDA) method in mice. Laboratory Animals 59(5), 578–587.

Applicability of the micropipette-guided drug administration (MDA) method for assessing reward-related behaviors in mice

Oral gavage is the standard method for acute or chronic per os treatments in laboratory rodents. It can, however, induce significant stress responses and compromise the welfare of animals. To mitigate these concerns, we recently introduced the micropipette-guided drug administration...

Year Published: 2025Topics: Drug/Substance AdministrationAnimal Type: Mouse, Rodent

Citation: Krzyzaniak, O., Steiner, S., Nilsson, F. A. M. et al. 2025. Applicability of the micropipette-guided drug administration (MDA) method for assessing reward-related behaviors in mice. Physiology & Behavior 299, 114967.

Diet gel-based oral drug delivery system for controlled dosing of small molecules for microglia depletion and inducible Cre recombination in mice

Small molecules such as PLX5622 for microglia depletion and tamoxifen for inducible Cre recombination are commonly used in mouse research. Traditional application methods such as drug-infused chow, oral gavage or injections have limitations, including uncontrolled dosing (chow) or risk of...

Year Published: 2025Topics: Drug/Substance AdministrationAnimal Type: Mouse, Rodent

Citation: Jovanovic, J., Stone, M. L., Dooyema, S. R. et al. 2025. Diet gel-based oral drug delivery system for controlled dosing of small molecules for microglia depletion and inducible Cre recombination in mice. Lab Animal 54(10), 278–285.

A new method to replace oral gavage for the study of Cryptosporidium infection in mice

Oral gavage is a widely used method to infect mice with Cryptosporidium parvum (CP), the most common animal model of infection. Cryptosporidium spp. are worldwide distributed, gastrointestinal parasites that mainly cause diarrhea in humans and neonatal ruminants. CP is transmitted...

Year Published: 2025Topics: Drug/Substance AdministrationAnimal Type: Mouse, Rodent

Citation: Fumuso, F. G., Salomon, C. E., O’Connor, R. M. 2025. A new method to replace oral gavage for the study of Cryptosporidium infection in mice. Laboratory Animals 59(5), 593–598.