Mouse

Behavioral Biology of Laboratory Animals (1st ed)

This 30-chapter volume informs students and professionals about the behavioral biology of animals commonly housed in laboratory and other captive settings. Each species evolved under specific environmental conditions, resulting in unique behavioral patterns, many of which are maintained in captivity...

Year Published: 2021Topics: Husbandry & Management, Natural Behavior, Welfare AssessmentAnimal Type: Amphibian, Baboon, Capuchin, Cat, Cattle, Chicken, Dog, Equine, Ferret, Fish, Fowl, Frog & Toad, Gerbil, Guinea Pig, Hamster, Lizard, Macaque, Marmoset, Mouse, Nonhuman Primate, Other Rodent, Owl Monkey, Pig, Rabbit, Rat, Reptile, Rodent, Salamander, Sheep, Snake, Squirrel Monkey, Turtle & Tortoise, Vervet (African Green Monkey), Zebrafish

Citation: Coleman, K., Shapiro, S. J. (Eds.). 2021. Behavioral Biology of Laboratory Animals (1st ed). CRC Press, Boca Raton, FL.

Animal-centric Care and Management – Enhancing Refinement in Biomedical Research

The concept of the 3Rs (Refinement, Reduction and Replacement) has been used as a framework for improving the welfare of laboratory animals for the last half century. By establishing an animal-centric view on housing and management, Animal-centric Care and Management:...

Year Published: 2021Topics: Abnormal/Problematic Behavior, Animal Training, Emotion, Pain, & Sentience, Environmental Enrichment, Handling, Housing, Human-Animal Interaction, Husbandry & Management, Natural Behavior, Social Housing & CompanionshipAnimal Type: All/General, Dog, Fish, Macaque, Marmoset, Mouse, Nonhuman Primate, Other Nonhuman Primate, Pig, Rabbit, Rat, Rodent, Zebrafish

Citation: Sørensen, D., Cloutier, S., Gaskill, B. (Eds.). 2021. Animal-centric Care and Management - Enhancing Refinement in Biomedical Research. CRC Press, Boca Raton, FL.

Preclinical validation of the micropipette-guided drug administration (MDA) method in the maternal immune activation model of neurodevelopmental disorders

Pharmacological treatments in laboratory rodents remain a cornerstone of preclinical psychopharmacological research and drug development. There are numerous ways in which acute or chronic pharmacological treatments can be implemented, with each method having certain advantages and drawbacks. Here, we describe...

Year Published: 2020Topics: Drug/Substance AdministrationAnimal Type: Mouse, Rodent

Citation: Scarborough, J., Mueller, F., Arban, R. et al. 2020. Preclinical validation of the micropipette-guided drug administration (MDA) method in the maternal immune activation model of neurodevelopmental disorders. Brain, Behavior, and Immunity 88, 461-470.

The development and use of facial grimace scales for pain measurement in animals

The measurement of pain in animals is surprisingly complex, and remains a critical issue in veterinary care and biomedical research. Based on the known utility of pain measurement via facial expression in verbal and especially non-verbal human populations, “grimace scales”...

Year Published: 2020Topics: Welfare AssessmentAnimal Type: Cat, Cattle, Equine, Ferret, Mouse, Pig, Rabbit, Rat, Rodent, Sheep

Citation: Mogil, J. S., Pang, D. S. J., Silva Dutra, G. G. et al. 2020. The development and use of facial grimace scales for pain measurement in animals. Neuroscience & Biobehavioral Reviews 116, 480-496.

Regular touchscreen training affects faecal corticosterone metabolites and anxiety-like behaviour in mice

Automated touchscreen techniques find increasing application for the assessment of cognitive function in rodents. However, hardly anything is known about the potential impact of touchscreen-based training and testing procedures on the animals under investigation. Addressing this question appears particularly important...

Year Published: 2021Topics: Animal TrainingAnimal Type: Mouse, Rodent

Citation: Krakenberg, V., Wewer,M., Palme, R. et al. 2021. Regular touchscreen training affects faecal corticosterone metabolites and anxiety-like behaviour in mice. Behavioural Brain Research 401, 113080.

Where are you from? Female mice raised in enriched or conventional cages differ socially, and can be discriminated by other mice

Laboratory rodents raised in environmentally-enriched (EE) cages differ behaviourally and cognitively from conventionally-housed (CH) animals. We hypothesised that mice can detect such differences, testing this using differentially-raised female C57BL/6 s as subjects, and differentially-raised female BALB/cs and DBA/2 s as...

Year Published: 2021Topics: Environmental EnrichmentAnimal Type: Mouse, Rodent

Citation: Adcock, A., Choleris, E., Denommé, M. et al. 2021. Where are you from? Female mice raised in enriched or conventional cages differ socially, and can be discriminated by other mice. Behavioural Brain Research 400, 113025.

Estimating mouse and rat use in American laboratories by extrapolation from Animal Welfare Act-regulated species

Alone among Western nations, the United States has a two-tier system for welfare protections for vertebrate animals in research. Because its Animal Welfare Act (AWA) excludes laboratory rats and mice (RM), government veterinarians do not inspect RM laboratories and RM...

Year Published: 2021Topics: Regulations & Ethical ReviewAnimal Type: Mouse, Rat, Rodent

Citation: Carbone, L. 2021. Estimating mouse and rat use in American laboratories by extrapolation from Animal Welfare Act-regulated species. Scientific Reports 11(1), 493.

Wellbeing of mice euthanized with carbon dioxide in their home cage as compared with an induction chamber

The AVMA Guidelines on Euthanasia state that, to decrease potential distress of animals, the home cage should be used for the euthanasia of mice. The current study evaluated this recommendation by comparing behavioral and physiologic changes in ICR and SJL...

Year Published: 2021Topics: EuthanasiaAnimal Type: Mouse, Rodent

Citation: Hickman, D. L. 2021. Wellbeing of mice euthanized with carbon dioxide in their home cage as compared with an induction chamber. JAALAS 60(1), 72-76.

Pharmacokinetics and efficacy of a long-lasting, highly concentrated buprenorphine solution in mice

Buprenorphine is a commonly used opioid for mitigating pain in laboratory mice after surgical procedures; however, the dosing interval necessary for standard buprenorphine may require treatment every 4 to 6 h to maintain an adequate plane of analgesia. An alternative...

Year Published: 2021Topics: AnalgesiaAnimal Type: Mouse, Rodent

Citation: Kendall, L. V., Singh, B., Bailey, A. L. et al. 2021. Pharmacokinetics and efficacy of a long-lasting, highly concentrated buprenorphine solution in mice. JAALAS 60(1), 64-71.

Replacement of surgical vasectomy through the use of wild-type sterile hybrids

For the production and rederivation of mouse strains, pseudopregnant female mice are used for embryo transfer and serve as surrogate mothers to support embryo development to term. Vasectomized males are commonly used to render pseudopregnancy in females, generated by surgical...

Year Published: 2021Topics: ReproductionAnimal Type: Mouse, Rodent

Citation: Preece, C., Alghadban, S., Bouchareb, A. et al. 2021. Replacement of surgical vasectomy through the use of wild-type sterile hybrids. Lab Animal 50, 49-52.