Drug/Substance Administration

Evaluation of parameters which influence voluntary ingestion of supplements in rats

Drug safety and efficacy studies frequently use oral gavage, but repetitive usage may cause problems. Administration through voluntary ingestion represents an opportunity for refinement. We aimed to develop a protocol for voluntary ingestion of gelatin-based supplements in rats, assessing the...

Year Published: 2023Topics: Animal Training, Drug/Substance AdministrationAnimal Type: Rat, Rodent

Citation: Ruvira, S., Rodríguez-Rodríguez, P., Cañas, S. et al. 2023. Evaluation of parameters which influence voluntary ingestion of supplements in rats. Animals 13(11), 1827.

Ultrasound guided surgery as a refinement tool in oncology research

Refinement is one of the ethical pillars of the use of animals in research. Ultrasonography is currently used in human medicine as a surgical tool for guided biopsies and this idea can be applied to preclinical research thanks to the...

Year Published: 2022Topics: Disease/Experimental Model, Drug/Substance Administration, Imaging & Electrophysiological Recording, Surgery & Post-OpAnimal Type: All/General

Citation: Serrano, C., Antonio, J. 2022. Ultrasound guided surgery as a refinement tool in oncology research. Animals 12(23), 3445.

Intranasal atomization of ketamine, medetomidine and butorphanol in pet rabbits using a mucosal atomization device

A non-invasive method of drug delivery, intranasal atomization, has shown positive results in human medicine and in some animal species. The objective of this study was to evaluate the effects of intranasal atomization, compared to intramuscular administration, of a mix...

Year Published: 2023Topics: Anesthesia & Sedation, Drug/Substance AdministrationAnimal Type: Rabbit

Citation: Mauthe von Degerfeld, M., Serpieri, M., Bonaffini, G. et al. 2023. Intranasal atomization of ketamine, medetomidine and butorphanol in pet rabbits using a mucosal atomization device. Animals 13(13), 2076.

Development of a 3D simulator for training the mouse in utero electroporation

In utero electroporation (IUE) requires high-level training in microinjection through the mouse uterine wall into the lateral ventricle of the mouse brain. Training for IUE is currently being performed in live mice as no artificial models allow simulations yet. This...

Year Published: 2022Topics: Disease/Experimental Model, Drug/Substance Administration, ReproductionAnimal Type: Mouse, Rodent

Citation: Nuber, M., Gonzalez-Uarquin, F., Neufurth, M. et al. 2022. Development of a 3D simulator for training the mouse in utero electroporation. PLOS ONE 17(12), e0279004.

Voluntary oral dosing for precise experimental compound delivery in adult rats

Preclinical drug studies routinely administer experimental compounds to animal models with the goal of minimizing potential adverse events from the procedure. In this study, we assessed the ability to train adult male Long Evans rats to accept daily voluntarily syringe...

Year Published: 2022Topics: Drug/Substance AdministrationAnimal Type: Rat, Rodent

Citation: Chesler, K. C., Motz, C. T., Bales, K. L. et al. 2022. Voluntary oral dosing for precise experimental compound delivery in adult rats. Laboratory Animals 56(2), 147-156.

A quick and low-intensity method for oral administration to large numbers of mice: A possible alternative to oral gavage

Oral administration of medication to experimental animals is a cause of significant stress. When coupled to animals who are already under strenuous circumstances due to the disease being modelled, there is a significant risk for increased morbidity and mortality, thus...

Year Published: 2022Topics: Drug/Substance AdministrationAnimal Type: Mouse, Rodent

Citation: Neto, T., Faustino-Rocha, A. I., Gil da Costa, R. M. et al. 2022. A quick and low-intensity method for oral administration to large numbers of mice: A possible alternative to oral gavage. Laboratory Animals 56(2), 185-190.

Efficacy of lidocaine topical solution in reducing discomfort reaction of horses to intramuscular vaccination

Vaccinations via intramuscular injection are a key component of preventative health care in horses. Development of problematic behavioral aversion to injections is quite common. Our clinical impression has been that topical anesthetic applied to injection sites can reduce the behavioral...

Year Published: 2022Topics: Analgesia, Drug/Substance AdministrationAnimal Type: Equine

Citation: Torcivia, C., McDonnell, S. 2022. Efficacy of lidocaine topical solution in reducing discomfort reaction of horses to intramuscular vaccination. Animals 12(13), 1659.

Refinement of handling and dosing methods for rats and mice

Modified Handling for Mice: Handling mice by gripping the base of the tail has been shown to negatively impact animal welfare by increasing anxiety and aversion to handling. We aimed to refi ne the dosing procedure by finding a handling...

Year Published: 2022Topics: Drug/Substance Administration, HandlingAnimal Type: Mouse, Rat, Rodent

Citation: Bartlett, J., Davies, J., Purawijaya, D. et al. 2022. Refinement of handling and dosing methods for rats and mice. Animal Technology and Welfare 21(2), 120-124.

Medicated jelly as a replacement for injectables and the use of Maropitant to manage itchy skin in mice

It is desirable to administer drugs by the least invasive route to (1) optimise welfare, (2) reduce the risk of injury to animal handlers and (3) minimise the impact of restraint and transient pain on physiological and experimental readouts. Bio-Serv®...

Year Published: 2022Topics: Drug/Substance AdministrationAnimal Type: Mouse, Rodent

Citation: Donaldson-Wing, M. 2022. Medicated jelly as a replacement for injectables and the use of Maropitant to manage itchy skin in mice. Animal Technology and Welfare 21(2), 134-136.

Development and implementation of a positive reinforcement training program for nonhuman primates in biomedical research

Despite clear benefits of PRT for NHPs and biomedical research, investigators often view the investment in personnel expertise and time required to train animals as deterrents towards adopting PRT. We provide an example of how this framework could be implemented...

Year Published: 2022Topics: Animal Training, Drug/Substance AdministrationAnimal Type: Macaque, Nonhuman Primate

Citation: Guerrero-Martin, S. M., Brill, S., Carlson, B. W. 2022. Development and implementation of a positive reinforcement training program for nonhuman primates in biomedical research. Laboratory Animal Science Professional 10(1) (January/February), 48-52.