Disease/Experimental Model

Refining the unilateral ureteral obstruction mouse model: No sham, no shame

Fibrosis, as a common final pathway in many renal diseases, contributes significantly to the decline of organ function and to progression to end-stage renal disease. To establish therapeutic interventions that target fibrosis, animal models are essential. The most widely used...

Year Published: 2021Topics: Disease/Experimental ModelAnimal Type: Mouse, Rodent

Citation: Atkinson, J., Boden, T., Mocho J.-P. et al. 2021. Refining the unilateral ureteral obstruction mouse model: No sham, no shame. Laboratory Animals 55(1), 21-29.

Application of the 3R principles: Vertebrae as an additional source of murine bone-marrow cells

Experimental murine models are an essential tool in the field of bone marrow (BM) transplantation research. Therefore, numerous mice are required to obtain a sufficient number of BM cells, which is in contrast with the Reduction principle of the 3R...

Year Published: 2021Topics: Disease/Experimental ModelAnimal Type: Mouse, Rodent

Citation: Justin, M., Jež, M., Košir, A. et al. 2021. Application of the 3R principles: Vertebrae as an additional source of murine bone-marrow cells. Laboratory Animals 55(1), 43-52.

Assessment of a noninvasive chronic glucose monitoring system in euglycemic and diabetic swine (Sus scrofa)

Models of type-I diabetes are well-characterized and commonly used in the preclinical evaluation of drugs and medical devices. The diabetic minipig is an excellent example of a translational model. However, chronic glucose monitoring in this species can be challenging; frequent...

Year Published: 2020Topics: Biological Sampling & Physiological Measurement, Disease/Experimental Model, External Bodily EquipmentAnimal Type: Pig

Citation: Ober, R. A., Geist, G. E. 2020. Assessment of a noninvasive chronic glucose monitoring system in euglycemic and diabetic swine (Sus scrofa). JAALAS 59(4), 430-437.

Management of morbidity and mortality in a New Zealand white rabbit model of steroidinduced osteonecrosis of the femoral head

Steroid-induced osteonecrosis of the femoral head (SONFH) is a condition documented in humans and animals exposed to chronic steroid administration. The rabbit has become a preferred animal model for investigating the pathogenesis and treatment of SONFH due to its shared...

Year Published: 2021Topics: Disease/Experimental Model, Welfare AssessmentAnimal Type: Rabbit

Citation: Casey, K. M., Gore, F., Vilches-Moure, J. G. et al. 2021. Management of morbidity and mortality in a New Zealand white rabbit model of steroidinduced osteonecrosis of the femoral head. Comparative Medicine 71(1), 86-98.

Evaluation of nutritional gel supplementation in C57BL/6J mice infected with mouse-adapted Influenza A/PR/8/34 virus

Mice are a common animal model for the study of influenza virus A (IAV). IAV infection causes weight loss due to anorexia and dehydration, which can result in early removal of mice from a study when they reach a humane...

Year Published: 2020Topics: Disease/Experimental Model, Husbandry & ManagementAnimal Type: Mouse, Rodent

Citation: Felgenhauer, J. L., Brune, J. E., Long, M. E. et al. 2020. Evaluation of nutritional gel supplementation in C57BL/6J mice infected with mouse-adapted Influenza A/PR/8/34 virus. Comparative Medicine 70(6), 471-486.

Automated and continuous monitoring of animal welfare through digital alerting

A primary goal in preclinical animal research is respectful and responsible care aimed toward minimizing stress and discomfort while enhancing collection of accurate and reproducible scientific data. Researchers use hands-on clinical observations and measurements as part of routine husbandry procedures...

Year Published: 2020Topics: Disease/Experimental Model, Humane Endpoint, Welfare AssessmentAnimal Type: Mouse, Rat, Rodent

Citation: Do, J. P., Defensor, E. B., Ichim, C. V. et al. 2020. Automated and continuous monitoring of animal welfare through digital alerting. Comparative Medicine 70(4), 313-327.

Fasting of male mice – Effects of time point of initiation and duration on clinical chemistry parameters and animal welfare

Fasting of mice is a common procedure, which can affect the outcome of the study as well as animal welfare. In this study, we assess the effects of fasting, fasting duration and fasting initiation time in relation to light schedule...

Year Published: 2019Topics: Disease/Experimental Model, Husbandry & ManagementAnimal Type: Mouse, Rodent

Citation: Jensen, T. L., Kiersgaard, M. K., Mikkelsen, L. F. et al. 2019. Fasting of male mice – Effects of time point of initiation and duration on clinical chemistry parameters and animal welfare. Laboratory Animals 53(6), 587–597.

Inventive enrichment to facilitate weight gain in the common marmoset (Callithrix jacchus) during invasive studies

To provide the highest standard of care to marmosets during invasive surgical studies, studies that often lead to weight loss, it is paramount to call upon inherent species-specific enrichment tactics to mitigate weight loss. Weight loss is common in marmosets...

Year Published: 2019Topics: Disease/Experimental Model, Environmental EnrichmentAnimal Type: Macaque, Nonhuman Primate

Citation: Heyworth, C. 2019. Inventive enrichment to facilitate weight gain in the common marmoset (Callithrix jacchus) during invasive studies. Laboratory Animal Science Professional 7(4) (December), 38-41.

Non-aversive photographic measurement method for subcutaneous tumours in nude mice

We have developed a new method for the measurement of subcutaneous tumour volume which consists in taking photographs of mice in their home cages, to refine the standard method of measurement with calipers. We consider this new method to be...

Year Published: 2019Topics: Disease/Experimental Model, Welfare AssessmentAnimal Type: Mouse, Rodent

Citation: Resasco, A., Carranza Martin, A. C., Ayala, M. A. et al. 2019. Non-aversive photographic measurement method for subcutaneous tumours in nude mice. Laboratory Animals 53(4), 352–361.

Evaluation of the effectiveness of preoperative administration of maropitant citrate and metoclopramide hydrochloride in preventing postoperative clinical gastroesophageal reflux in dogs

OBJECTIVE To investigate the prophylactic effectiveness of preoperative administration of maropitant citrate and metoclopramide hydrochloride in preventing postoperative clinical gastroesophageal reflux (GER) in dogs and to identify risk factors for clinical postoperative GER in dogs. ANIMALS 93 client-owned dogs undergoing...

Year Published: 2019Topics: Disease/Experimental ModelAnimal Type: Dog

Citation: Jones, C. T., Fransson, B. A. 2019. Evaluation of the effectiveness of preoperative administration of maropitant citrate and metoclopramide hydrochloride in preventing postoperative clinical gastroesophageal reflux in dogs. Journal of the American Veterinary Medical Association 255(4), 437-445.