Disease/Experimental Model

Fasting is not required for measuring plasma lipid levels in rabbits

Plasma lipid and glucose levels are important parameters for evaluating the onset and development of metabolic and cardiovascular diseases. In clinical and experimental studies of humans or mice, fasting is often required before testing plasma lipid and glucose levels. The...

Year Published: 2020Topics: Disease/Experimental Model, Husbandry & ManagementAnimal Type: Rabbit

Citation: Wang, R., Liu, R., Li, L. et al. 2020. Fasting is not required for measuring plasma lipid levels in rabbits. Laboratory Animals 54(3), 272–280.

Four- and six-hour urinary albumin excretion is a valuable alternative to 24-h urinary albumin excretion in male db/db mice

In mouse (Mus musculus) models of diabetic nephropathy (DN), one of the most important read-outs is the 24-h urinary albumin excretion (UAE). The 24-h urine collection is usually performed by single housing mice in metabolic cages on wire mesh without...

Year Published: 2020Topics: Biological Sampling & Physiological Measurement, Disease/Experimental ModelAnimal Type: Mouse, Rodent

Citation: Nøgaard, S. A., Sand, F. W., Sørensen, D. B. et al. 2020. Four- and six-hour urinary albumin excretion is a valuable alternative to 24-h urinary albumin excretion in male db/db mice. Animal Welfare 29(2), 143-149.

Humane endpoints in severe irradiation experiments using non-human primates: A retrospective analysis

A retrospective statistical study has been performed in order to identify the biological, clinical and behavioural variables that could potentially predict the survival status of irradiated non-human primates (NHP) and to refine the future use of humane endpoints (HEP). The...

Year Published: 2020Topics: Disease/Experimental Model, Humane EndpointAnimal Type: Macaque, Nonhuman Primate

Citation: Bertho, J.-M., Ancelet, S., Denais-Laliève, D. et al. 2020. Humane endpoints in severe irradiation experiments using non-human primates: A retrospective analysis. Scandinavian Journal of Laboratory Animal Science 46(1).

Nursing and training of pigs used in renal transplantation studies

The pig is commonly used in renal transplantation studies since the porcine kidney resembles the human kidney. To meet the requirements of intense caretaking and examination without stress, a 2-week socialisation and training programme was developed. Conventional cross-breed pigs (n = 36)...

Year Published: 2020Topics: Animal Training, Disease/Experimental ModelAnimal Type: Pig

Citation: Rydén, A., Manell, E., Biglarnia, A. et al. 2020. Nursing and training of pigs used in renal transplantation studies. Laboratory Animals 54(5), 469-478.

Optimising streptozotocin dosing to minimise renal toxicity and impairment of stomach emptying in male 129/Sv mice

The streptozotocin (STZ)-induced diabetic mouse model has been extensively used as a model for diabetes and diabetic nephropathy, but it is still influenced by many off-target toxic effects and large variation in diabetes induction. Therefore, the aim of this study...

Year Published: 2020Topics: Disease/Experimental ModelAnimal Type: Mouse, Rodent

Citation: Nørgaard, S. A., Søndergaard, H., Sørensen, D. B. et al. 2020. Optimising streptozotocin dosing to minimise renal toxicity and impairment of stomach emptying in male 129/Sv mice. Laboratory Animals 54(4), 341–352.

Performance of severity parameters to detect chemotherapy-induced pain and distress in mice

According to European Union directive 2010/63/EU a severity classification of experimental procedures performed on laboratory animals is mandatory. This includes a prospective evaluation of all interventions performed within the experiment, as well as an assessment of the actual burden of...

Year Published: 2020Topics: Disease/Experimental Model, Welfare AssessmentAnimal Type: Mouse, Rodent

Citation: Rix, A., Drude, N., Mrugalla, A. et al. 2020. Performance of severity parameters to detect chemotherapy-induced pain and distress in mice. Laboratory Animals 54(5), 452-460.

Progressing the care, husbandry and management of ageing mice used in scientific studies

Driven by the longer lifespans of humans, particularly in Westernised societies, and the need to know more about ‘healthy ageing’, ageing mice are being used increasingly in scientific research. Many departments and institutes involved with ageing research have developed their...

Year Published: 2020Topics: Disease/Experimental Model, Humane Endpoint, Welfare AssessmentAnimal Type: Mouse, Rodent

Citation: Wilkinson, M. J. A., Selman, C., McLaughlin, L. et al. 2020. Progressing the care, husbandry and management of ageing mice used in scientific studies. Laboratory Animals 54(3) 225–238.

Improving pain management for murine orthotopic xenograft models of acute lymphoblastic leukemia

Despite ongoing research, realistic in vitro models for acute lymphoblastic leukemia (ALL) that can mimic the complex pathology are still not available, highlighting the need for continuous animal-based investigation. As part of the 3R principles, constant refinement of animal experiments...

Year Published: 2025Topics: Analgesia, Disease/Experimental ModelAnimal Type: Mouse, Rodent

Citation: Schreiber, T., Lange, S., Talbot, S. R. et al. 2025. Improving pain management for murine orthotopic xenograft models of acute lymphoblastic leukemia. Lab Animal 54(11), 313–320.

Behavioral assessment of tramadol and meloxicam effects on postoperative pain in a rat craniotomy model

Stereotaxic surgery is a common procedure in neuroscience, yet effective analgesic protocols require further study and refinement to optimize the analgesia used in invasive procedures and to improve animal welfare. This study evaluated the effects of tramadol and meloxicam, alone...

Year Published: 2025Topics: Analgesia, Disease/Experimental ModelAnimal Type: Rat, Rodent

Citation: Alemán-Laporte, J., Alvarado, G., Pellagio, N. B. et al. 2025. Behavioral assessment of tramadol and meloxicam effects on postoperative pain in a rat craniotomy model. JAALAS 64(4), 716–725.

Maintenance of the Brugia Malayi life cycle in Mongolian gerbils

The Mongolian gerbil or jird (Meriones unguiculatus) is a rodent belonging to the subfamily Gerbillinae. They are commonly used as models for a variety of infectious diseases such as Hepatitis E virus and Giardia lamblia. At the LSTM/University of Liverpool...

Year Published: 2025Topics: Cannulation, Catheterization, & Intubation, Disease/Experimental Model, Drug/Substance AdministrationAnimal Type: Gerbil, Rodent

Citation: Steven, A. 2025. Maintenance of the Brugia Malayi life cycle in Mongolian gerbils. Animal Technology and Welfare 24(2), 155–156.