Analgesia

Alteration in activity patterns of cows as a result of pain due to health conditions

The main conditions and diseases considered painful in dairy cows are mastitis, lameness, calving (including dystocia and caesarean section) and metritis. The cattle literature reports that deviation from normal daily activity patterns (both increased and/or reduced daily lying time) can...

Year Published: 2022Topics: Analgesia, Welfare AssessmentAnimal Type: Cattle

Citation: Mainau, E., Llonch, P., Temple, D. et al. 2022. Alteration in activity patterns of cows as a result of pain due to health conditions. Animals 12(2), 176.

Comparison of nociceptive effects of buprenorphine, firocoxib, and meloxicam in a plantar incision model in Sprague–Dawley rats

Due to their reduced frequency of dosing and ease of availability, NSAIDs are generally preferred over opioids for rodent analgesia. We evaluated the efficacy of the highly COX2-selective NSAID firocoxib as compared with meloxicam and buprenorphine for reducing allodynia and...

Year Published: 2021Topics: Analgesia, Disease/Experimental ModelAnimal Type: Rat, Rodent

Citation: Bennett, T. E., Pavek, T. J., Schwark, W. S. et al. 2021. Comparison of nociceptive effects of buprenorphine, firocoxib, and meloxicam in a plantar incision model in Sprague–Dawley rats. JAALAS 60(5), 539-548.

Analgesic efficacy of tramadol and morphine in White’s tree frogs (Litoria caerulea)

Published data are sparse regarding the recognition of clinically relevant pain and appropriate analgesia in amphibians. The amphibian analgesia literature has primarily focused on nociceptive pathways in a single species, the northern leopard frog (Rana pipiens). The objective of the...

Year Published: 2021Topics: Analgesia, Welfare AssessmentAnimal Type: Amphibian, Frog & Toad

Citation: Hausmann, J. C., Krisp, A. R., Mans, C. et al. 2021. Analgesic efficacy of tramadol and morphine in White's tree frogs (Litoria caerulea). JAALAS 60(6), 681-686.

Analgesic effects of intravenous flunixin and intrafunicular lidocaine or their combination for castration of lambs

Objective: To analyse the effectiveness of intrafunicular lidocaine and intravenous flunixin for reducing pain and signs of stress in lambs undergoing surgical castration. Design: Randomised controlled trial. Setting: One university teaching hospital in Italy. Participants: 30 healthy male lambs, 9–12...

Year Published: 2018Topics: Analgesia, Body Modification/MutilationAnimal Type: Sheep

Citation: Straticò, P., Varasano, V., Suriano, R. et al. 2018. Analgesic effects of intravenous flunixin and intrafunicular lidocaine or their combination for castration of lambs. Veterinary Record Open 5(1), e000266.

Use of food enrichment for medication delivery in large groups of sheep

In a 2018 AALAS webinar on Sheep and Goat Analgesia, Dr. Susie Vogel, a small ruminant expert, introduced the concept of getting sheep and goats to willingly take medication by putting it in a tasty food treat. I had doubts...

Year Published: 2021Topics: Analgesia, Animal Training, Drug/Substance AdministrationAnimal Type: Sheep

Citation: Wilson-Welder, J. H., Frank, A. T. 2021. Use of food enrichment for medication delivery in large groups of sheep. Laboratory Animal Science Professional 9(3) (May/June), 40-43.

Pain management in farm animals: Focus on cattle, sheep and pigs

Pain causes behavioral, autonomic, and neuroendocrine changes and is a common cause of animal welfare compromise in farm animals. Current societal and ethical concerns demand better agricultural practices and improved welfare for food animals. These guidelines focus on cattle, sheep,...

Year Published: 2021Topics: Analgesia, Body Modification/Mutilation, Welfare AssessmentAnimal Type: Cattle, Pig, Sheep

Citation: Steagall, P. V., Bustamante, H., Johnson, C. B. et al. 2021. Pain management in farm animals: Focus on cattle, sheep and pigs. Animals 11(6), 1483.

Sustained release buprenorphine effectively attenuates postoperative hypersensitivity in an incisional pain model in neonatal rats (Rattus norvegicus)

Despite the need for safe and effective postoperative analgesia in neonates, research regarding pain management in neonatal rodents is relatively limited. Here, we investigate whether sustained release buprenorphine (Bup SR) effectively attenuates thermal hypersensitivity in a neonatal rat model of...

Year Published: 2021Topics: Analgesia, Disease/Experimental ModelAnimal Type: Rat, Rodent

Citation: Blaney, A., Jampachaisri, K., Huss, M. K. et al. 2021. Sustained release buprenorphine effectively attenuates postoperative hypersensitivity in an incisional pain model in neonatal rats (Rattus norvegicus). PLOS ONE 16(2), e0246213.

Buprenorphine, but not lidocaine, effectively attenuates post-operative thermal hypersensitivity in an incisional model in neonatal rats (Rattus norvegicus)

There is limited information on safe and effective neonatal rodent analgesia. The aim of this study was to evaluate the efficacy and duration of analgesia provided by buprenorphine (Bup) and lidocaine (Lid) in an incisional pain model. Male and female...

Year Published: 2021Topics: Analgesia, Surgery & Post-OpAnimal Type: Rat, Rodent

Citation: Katz, E. M., Huss, M. K., Jampachaisri, K. et al. 2021. Buprenorphine, but not lidocaine, effectively attenuates post-operative thermal hypersensitivity in an incisional model in neonatal rats (Rattus norvegicus). Scandinavian Journal of Laboratory Animal Science 47(1), 1-11.

Pharmacokinetics and efficacy of a long-lasting, highly concentrated buprenorphine solution in mice

Buprenorphine is a commonly used opioid for mitigating pain in laboratory mice after surgical procedures; however, the dosing interval necessary for standard buprenorphine may require treatment every 4 to 6 h to maintain an adequate plane of analgesia. An alternative...

Year Published: 2021Topics: AnalgesiaAnimal Type: Mouse, Rodent

Citation: Kendall, L. V., Singh, B., Bailey, A. L. et al. 2021. Pharmacokinetics and efficacy of a long-lasting, highly concentrated buprenorphine solution in mice. JAALAS 60(1), 64-71.

A comparison of buprenorphine, sustained release buprenorphine, and high concentration buprenorphine in male New Zealand white rabbits

Pain management in rabbits can be difficult because they are adept at hiding pain and can be stressed by handling and restraint for injection. The use of opioid analgesics with prolonged durations of activity could alleviate pain, but associated adverse...

Year Published: 2020Topics: AnalgesiaAnimal Type: Rabbit

Citation: Andrews, D. D., Fajt, V. R., Baker, K. C. et al. 2020. A comparison of buprenorphine, sustained release buprenorphine, and high concentration buprenorphine in male New Zealand white rabbits. JAALAS 59(5), 546-556.