Analgesia

Updated review of fish analgesia

Analgesics are an integral part of routine pain management in mammals, yet their use in fish is still limited. Some recommendations on the use of analgesics in fish are currently in the literature; however, information on the properties of analgesic...

Year Published: 2018Topics: AnalgesiaAnimal Type: Fish, Other Fish, Salmon, Tilapia, Trout, Zebrafish

Citation: Chatigny, F., Creighton, C. M., Stevens, E. D. 2018. Updated review of fish analgesia. JAALAS 57(1), 5-12.

Pharmacokinetics and adverse effects of 3 sustained-release buprenorphine dosages in healthy guinea pigs (Cavia porcellus)

In guinea pigs, studies addressing the efficacy, safety, and pharmacokinetic profiles of different sustained-release buprenorphine (SRB) formulations are still in their infancy. Here we assessed the pharmacokinetic profiles of 3 SRB dosages (SR-LAB, ZooPharm; SRBLow, 0.15 mg/kg; SRBMedium, 0.3 mg/kg;...

Year Published: 2017Topics: AnalgesiaAnimal Type: Guinea Pig, Rodent

Citation: Zanetti, A. S., Putta, S. K., Casebolt, D. B. et al. 2017. Pharmacokinetics and adverse effects of 3 sustained-release buprenorphine dosages in healthy guinea pigs (Cavia porcellus). JAALAS 56(6), 768-778.

Analgesic efficacy and safety of buprenorphine in chinchillas (Chinchilla lanigera)

Buprenorphine is routinely used in chinchillas at reported doses of 0.01 to 0.1 mg/kg IM or SC. However, these dose recommendations are based on anecdotal reports or extrapolation from studies in other species. Therefore, the purpose of this study was...

Year Published: 2018Topics: AnalgesiaAnimal Type: Chinchilla, Rodent

Citation: Fox, L., Mans, C. 2018. Analgesic efficacy and safety of buprenorphine in chinchillas (Chinchilla lanigera). JAALAS 57(3), 286-290.

Analgesic efficacy and safety of hydromorphone in chinchillas (Chinchilla lanigera)

Limited information is available regarding the efficacy of opioid analgesics in chinchillas. Here we sought to evaluate the analgesic efficacy and safety of hydromorphone in chinchillas. In a randomized, controlled, blind, complete crossover design, hydromorphone was administered at 0.5, 1,...

Year Published: 2018Topics: AnalgesiaAnimal Type: Chinchilla, Rodent

Citation: Evenson, E. A., Mans, C. 2018. Analgesic efficacy and safety of hydromorphone in chinchillas (Chinchilla lanigera). JAALAS 57(3), 282-285.

Comparison of etomidate, benzocaine, and MS222 anesthesia with and without subsequent flunixin meglumine analgesia in African clawed frogs (Xenopus laevis)

Often few alternative anesthetics for exotic species are available, due to the small numbers of these animals used in research. In this study, we evaluated the depth and duration of anesthesia in Xenopus laevis after their immersion in 3 doses...

Year Published: 2018Topics: Analgesia, Anesthesia & SedationAnimal Type: Amphibian, Frog & Toad

Citation: Smith, B. D., Vail, K. J., Carroll, G. L. et al. 2018. Comparison of etomidate, benzocaine, and MS222 anesthesia with and without subsequent flunixin meglumine analgesia in African clawed frogs (Xenopus laevis). JAALAS 57(2), 202-209.

Analgesic efficacy of subcutaneous–oral dosage of tramadol after surgery in C57BL/6J mice

This study investigated the analgesic activity of tramadol in female C57BL/6J mice by using a single subcutaneous injection (25 mg/kg) of tramadol combined with the same dose given in drinking water for 24 h. We then evaluated the pharmacokinetics of...

Year Published: 2018Topics: AnalgesiaAnimal Type: Mouse, Rodent

Citation: Evangelista-Vaz, R., Bergadano, A., Arras, M. et al. 2018. Analgesic efficacy of subcutaneous–oral dosage of tramadol after surgery in C57BL/6J mice. JAALAS 57(4), 368-375.

Analgesic efficacy and hematologic effects of robenacoxib in mice

NSAID analgesics may confound models that require inflammation to mimic disease development in humans. This effect presents a challenge for veterinary staff and investigators, because surgery is often necessary to create mouse models of disease and NSAID are first-line analgesics...

Year Published: 2018Topics: AnalgesiaAnimal Type: Mouse, Rodent

Citation: Beninson, J. A., Lofgren, J. L., Lester, P. A. et al. 2018. Analgesic efficacy and hematologic effects of robenacoxib in mice. JAALAS 57(3), 258-267.

Side effects of pain and analgesia in animal experimentation

This review highlights selected effects of untreated pain and of widely used analgesics such as opioids, non-steroid anti-inflammatory drugs and antipyretics, to illustrate the relevance of carefully planned, appropriate and controlled analgesia for greater reproducibility in animal experiments involving laboratory...

Year Published: 2017Topics: AnalgesiaAnimal Type: Mouse, Rat, Rodent

Citation: Jirkof, P. 2017. Side effects of pain and analgesia in animal experimentation. Lab Animal 46(4), 123-128.

Evaluation of buprenorphine hydrochloride Pluronic® gel formulation in male C57BL/6NCrl mice

Providing adequate analgesia while minimizing handling and stress post-surgery can be challenging. Recently, there have been commercial products made available for providing long acting analgesia in rodents. However, we find there are limitations for use in mice due to the...

Year Published: 2016Topics: AnalgesiaAnimal Type: Mouse, Rodent

Citation: Blankenship-Paris, T. L., Dutton, J. W., Goulding, D. R. et al. 2016. Evaluation of buprenorphine hydrochloride Pluronic® gel formulation in male C57BL/6NCrl mice. Lab Animal 45(10), 370-379.

Femoral and sciatic nerve blockades and incision site infiltration in rabbits undergoing stifle joint arthrotomy

This study was designed to determine whether perineural injections of local anaesthetics decreases intraoperative nociception and improves postoperative analgesia in New Zealand White rabbits undergoing experimental stifle arthrotomy. All animals were anaesthetized using isoflurane and received morphine intramuscularly. The sciatic...

Year Published: 2017Topics: AnalgesiaAnimal Type: Rabbit

Citation: Kluge, K., Larenza Menzies, M. P., Kloeppel, H. et al. 2017. Femoral and sciatic nerve blockades and incision site infiltration in rabbits undergoing stifle joint arthrotomy. Laboratory Animals 51(1), 54-64.