Analgesia

Improving pain management for murine orthotopic xenograft models of acute lymphoblastic leukemia

Despite ongoing research, realistic in vitro models for acute lymphoblastic leukemia (ALL) that can mimic the complex pathology are still not available, highlighting the need for continuous animal-based investigation. As part of the 3R principles, constant refinement of animal experiments...

Year Published: 2025Topics: Analgesia, Disease/Experimental ModelAnimal Type: Mouse, Rodent

Citation: Schreiber, T., Lange, S., Talbot, S. R. et al. 2025. Improving pain management for murine orthotopic xenograft models of acute lymphoblastic leukemia. Lab Animal 54(11), 313–320.

Behavioral assessment of tramadol and meloxicam effects on postoperative pain in a rat craniotomy model

Stereotaxic surgery is a common procedure in neuroscience, yet effective analgesic protocols require further study and refinement to optimize the analgesia used in invasive procedures and to improve animal welfare. This study evaluated the effects of tramadol and meloxicam, alone...

Year Published: 2025Topics: Analgesia, Disease/Experimental ModelAnimal Type: Rat, Rodent

Citation: Alemán-Laporte, J., Alvarado, G., Pellagio, N. B. et al. 2025. Behavioral assessment of tramadol and meloxicam effects on postoperative pain in a rat craniotomy model. JAALAS 64(4), 716–725.

Comparison of the anxiolytic and analgesic effects of gabapentin and pregabalin in cats: A systematic review

The present study aimed to systematically review the anxiolytic and analgesic effects of gabapentin and pregabalin in domestic cats to assess the quality of using these medications for stress, fear, and anxiety management, and the treatment of both acute and...

Year Published: 2025Topics: AnalgesiaAnimal Type: Cat

Citation: Miranda-Cortés, A. E., Prado-Ochoa, M. G., Díaz-Torres, R. et al. 2025. Comparison of the anxiolytic and analgesic effects of gabapentin and pregabalin in cats: A systematic review. Animals 15(16), 2346.

Current practices of pain assessment and analgesic use in laboratory mice: A 2022 FELASA Working Group survey

Assessing and alleviating pain in animals involved in research is critically important. However, the effective implementation of pain management depends on the knowledge and attitudes of the personnel involved. Following a Federation of European Laboratory Animal Science Associations ‘Pain in...

Year Published: 2025Topics: Analgesia, Welfare AssessmentAnimal Type: Mouse, Rodent

Citation: Gomez de Segura, I. A., Seeldrayers, S., Flecknell, P. 2025. Current practices of pain assessment and analgesic use in laboratory mice: A 2022 FELASA Working Group survey. Laboratory Animals 59(3), 396–412.

Comparison of different formulations of extended-release buprenorphine in perioperative pain management in common marmosets (Callithrix jacchus)

Common marmosets (Callithrix jacchus) are increasingly used in biomedical research and often undergo surgery as part of IACUC-approved protocols. Therefore, pain control is essential to their clinical management and welfare. Extended-release buprenorphine is a valuable opioid analgesic option, as it...

Year Published: 2025Topics: AnalgesiaAnimal Type: Marmoset, Nonhuman Primate

Citation: Mokhtar Pouriani, K., McAndrew, R., Chan, N. et al. 2025. Comparison of different formulations of extended-release buprenorphine in perioperative pain management in common marmosets (Callithrix jacchus). Journal of the American Association for Laboratory Animal Science 64(3), 374–384.

Ge, Y., Alamaw, E. D., Ray, R. R. et al. 2025. Analgesic efficacy of a long-acting transdermal buprenorphine in rats (Rattus norvegicus)

Zorbium is the first long-acting transdermal buprenorphine (LAT-bup) approved by the FDA for relieving postoperative pain in cats for 72 h. This study aimed to investigate LAT-bup’s efficacy for attenuating postoperative mechanical and thermal hypersensitivity in a rat incisional pain...

Year Published: 2025Topics: AnalgesiaAnimal Type: Rat, Rodent

Citation: Ge, Y., Alamaw, E. D., Ray, R. R. et al. 2025. Analgesic efficacy of a long-acting transdermal buprenorphine in rats (Rattus norvegicus). Journal of the American Association for Laboratory Animal Science 64(3), 406–413.

Assessment of postoperative analgesic efficacy and animal well-being using a novel triaxial accelerometer device, the rodent fitbit-like telemetry device

Accurate postoperative pain management is crucial for good animal welfare and science. We sought to evaluate mouse postoperative pain management efficacy by measuring activity using a novel triaxial acceleration device—the Rodent Fitbit-like telemetry device (RFB)—to monitor home cage activity. To...

Year Published: 2025Topics: Analgesia, Welfare AssessmentAnimal Type: Mouse, Rodent

Citation: Campbell, M., Tolwani, A., Tolwani, R. et al. 2025. Assessment of postoperative analgesic efficacy and animal well-being using a novel triaxial accelerometer device, the rodent fitbit-like telemetry device. Journal of the American Association for Laboratory Animal Science 64(3), 457–467.

The effects of subcutaneous ketamine on postlaparotomy analgesia and behavior in female Sprague–Dawley rats (Rattus norvegicus)

Multimodal analgesia provides superior pain control compared with single-agent analgesic approaches. However, certain analgesic drug classes such as NSAIDs and opioids may be contraindicated in some studies due to their mechanisms of action, highlighting the need for alternative analgesic options....

Year Published: 2025Topics: AnalgesiaAnimal Type: Rat, Rodent

Citation: Alionhart, R. E., Carlson, M. M., White, A. R. et al. 2025. The effects of subcutaneous ketamine on postlaparotomy analgesia and behavior in female Sprague–Dawley rats (Rattus norvegicus). Journal of the American Association for Laboratory Animal Science 64(3), 468–479.

Self-administration of meloxicam via medicated molasses lick blocks may improve welfare of castrated calves (2025)

The self-administration of meloxicam via medicated feed is a novel concept that could enable non-invasive, pre-emptive and long-term analgesia. Forty Bos taurus male calves were randomly allocated to four treatment groups: no castration (PC), surgical castration (NC), surgical castration with...

Year Published: 2025Topics: Analgesia, Body Modification/MutilationAnimal Type: Cattle

Citation: Rudd, S., Lomax, S., White, P. J. et al. 2025. Self-administration of meloxicam via medicated molasses lick blocks may improve welfare of castrated calves. Animals 15(3), 442.

Analgesia administration practices to support minimal handling (2024)

An adequate analgesic strategy is important to improve the postoperative recovery and welfare of laboratoy animals. It is desirable that the method for administering the drug is non-invasive and stress-free. Below are a few methods that we use to minimise...

Year Published: 2024Topics: Analgesia, Drug/Substance Administration, Surgery & Post-OpAnimal Type: Mouse, Rodent

Citation: Keenan, R., Lynch, A., Murphy, S. et al. 2024. Analgesia administration practices to support minimal handling. Animal Technology and Welfare 23(3), 239–240.