Publications

Assessing susceptibility to carbon dioxide gas in three rat strains using the loss of righting reflex

Overdose of carbon dioxide gas (CO2) is a common euthanasia method for rodents; however, CO2 exposure activates nociceptors in rats at concentrations equal to or greater than 37% and is reported to be painful in humans at concentrations equal to...

Year Published: 2024Topics: EuthanasiaAnimal Type: Rat, Rodent

Citation: Merenick, D. R., Munro, B. A., Gee, J. M. et al. 2024. Assessing susceptibility to carbon dioxide gas in three rat strains using the loss of righting reflex. JAALAS 63(3), 310–315.

Comparison of hemodynamic effects of propofol or alfaxalone during induction in dogs

This randomized prospective clinical study aimed to compare the hemodynamic effects of propofol and alfaxalone for the induction of anesthesia in dogs. Thirty-one healthy dogs undergoing various procedures in a private referral center were premedicated with intramuscular acepromazine (0.015 mg/kg) and...

Year Published: 2024Topics: Anesthesia & SedationAnimal Type: Dog

Citation: Sarotti, D., Franci, P., Oricco, S. et al. 2024. Comparison of hemodynamic effects of propofol or alfaxalone during induction in dogs. Frontiers in Veterinary Science 11.

Pharmacokinetics of injectable meloxicam and buprenorphine in the naked mole-rat (Heterocephalus glaber)

Unique characteristics of the naked mole-rat (NMR) have made it increasingly popular as a laboratory animal model. These rodents are used to study many fields of research including longevity and aging, cancer, circadian rhythm, pain, and metabolism. Currently, the analgesic...

Year Published: 2024Topics: AnalgesiaAnimal Type: Other Rodent, Rodent

Citation: Moran, C. R., Park, T. J., Buffenstein, R. et al. 2024. Pharmacokinetics of injectable meloxicam and buprenorphine in the naked mole-rat (Heterocephalus glaber). JAALAS 63(5), 565–571.

Moving toward evidence-based care: Measuring preferences in zoo-housed aquatic turtles using 24-h remote monitoring

Providing evidence-based care to animals is a common goal in zoos and aquariums. However, there are many understudied species with a lack of information available, which may result in suboptimal care for individuals of these species. Using preference tests to...

Year Published: 2024Topics: Housing, Husbandry & ManagementAnimal Type: Reptile, Turtle & Tortoise

Citation: O'Brien, S. L., Koenig, S., Cronin, K. A. 2024. Moving toward evidence-based care: Measuring preferences in zoo-housed aquatic turtles using 24-h remote monitoring. Zoo Biology 43(5), 491–498.

Refinement of intranasal delivery in rats: A cadaveric study

The intranasal route enables direct delivery of multiple substances from the nose to the brain, through olfactory and trigeminal pathways, bypassing the blood–brain barrier and avoiding systemic absorption. Despite the potential of this route, the various administration approaches make data...

Year Published: 2024Topics: Drug/Substance AdministrationAnimal Type: Rat, Rodent

Citation: Pereira, M. N., Venâncio, C., Pinto, M. de L. et al. 2024. Refinement of intranasal delivery in rats: A cadaveric study. Laboratory Animals 58(4), 324–333.

Pharmacokinetics of extended-release buprenorphine and clinical efficacy for postoperative pain management in the domestic ferret (Mustela putorius furo)

Buprenorphine hydrochloride (Bup-HCl) is a common injectable opioid analgesic. In ferrets, Bup-HCl must be administered every 8 to 12 h to maintain clinical efficacy. Extended-release analgesics offer multiple advantages, including reduced handling and injection frequency, improved compliance, and increased protection...

Year Published: 2024Topics: AnalgesiaAnimal Type: Ferret

Citation: Plunkard, J. C. M., Jimenez, I. A., Tarwater, P. M. et al. 2024. Pharmacokinetics of extended-release buprenorphine and clinical efficacy for postoperative pain management in the domestic ferret (Mustela putorius furo). JAALAS 63(5), 552–564.

Comparison of novel and traditional bleeding techniques in neonatal and juvenile mice

Blood collection is frequently used for neonatal and juvenile mice in toxicology, developmental, and immunology studies and is often a terminal procedure. However, the use of nonterminal blood collection techniques, including the submandibular and the submental collection techniques described for...

Year Published: 2024Topics: Biological Sampling & Physiological MeasurementAnimal Type: Mouse, Rodent

Citation: Prentiss, R. L., Bollinger, B. L., Lamont, K. A. et al. 2024. Comparison of novel and traditional bleeding techniques in neonatal and juvenile mice. JAALAS 63(3), 333–342.

Weight as an indicator of enclosure suitability in Livingstone’s fruit bats (Pteropus livingstonii)

Obesity is common in zoo animals, and both dietary management and the provision of adequate opportunities for exercise are needed to tackle it. We used 30 years of records from Jersey Zoo to compare the weight and forearm length of...

Year Published: 2024Topics: HousingAnimal Type: Other Animal

Citation: Price, E. C., Roberts, A., Bennett, L. et al. 2024. Weight as an indicator of enclosure suitability in Livingstone's fruit bats (Pteropus livingstonii). Zoo Biology 43(4), 295–305.

Voluntary wheel running as an effective intervention in the management of excessive food usage in CD-1 mice (Mus musculus)

Some mice demonstrate excessive food-grinding behaviors in which food pellets are broken down into crumbs (orts). This is considered abnormal behavior and is undesirable in a research environment, as it is thought to potentially be a stereotypic behavior suggestive of...

Year Published: 2024Topics: Abnormal/Problematic BehaviorAnimal Type: Mouse, Rodent

Citation: Skurnack, A. M. E., Lane, S. P., Garman, L. et al. 2024. Voluntary wheel running as an effective intervention in the management of excessive food usage in CD-1 mice (Mus musculus). JAALAS 63(5), 504–512.

Refined tamoxifen administration in mice by encouraging voluntary consumption of palatable formulations

Drug administration in preclinical rodent models is essential for research and the development of novel therapies. Compassionate administration methods have been developed, but these are mostly incompatible with water-insoluble drugs such as tamoxifen or do not allow for precise timing...

Year Published: 2024Topics: Drug/Substance AdministrationAnimal Type: Mouse, Rodent

Citation: Vanhecke, D., Bugada, V., Steiner, R. et al. 2024. Refined tamoxifen administration in mice by encouraging voluntary consumption of palatable formulations. Lab Animal 53(8), 205–214.