Publications

Morbidity scoring after abdominal surgery

Postoperative monitoring of pain and distress in small rodents is not standardized, and widely accepted score sheets are not available. Here we describe a score sheet used in abdominal surgery of rodents, with particular reference to procedures involving the liver.

Year Published: 2016Topics: Welfare AssessmentAnimal Type: Mouse, Rat, Rodent

Citation: Graf, R., Cinelli, P., Arras, M. 2016. Morbidity scoring after abdominal surgery. Laboratory Animals 50(6), 453-458.

Recommendation for severity assessment following liver resection and liver transplantation in rats: Part I

Score sheets were first introduced 30 years ago to assess pain, distress and suffering in animals. To date, however, there is still no general agreement on their use in research practice, and only a few publications can be found on...

Year Published: 2016Topics: Welfare AssessmentAnimal Type: Rat, Rodent

Citation: Kanzler, S., Rix, A., Czigany, Z. et al. 2016. Recommendation for severity assessment following liver resection and liver transplantation in rats: Part I. Laboratory Animals 50(6), 459-467.

Severity assessment in rabbits after partial hepatectomy: Part II

Although the recognition of pain, distress and discomfort has already been described in 1985 by Morton and Griffiths there is still very little known about the establishment of score sheets especially, regarding postsurgical pain and severity assessment for laboratory animals...

Year Published: 2016Topics: Welfare AssessmentAnimal Type: Rabbit

Citation: Drude, N., Pawlowsky, K., Tanaka,H. et al. 2016. Severity assessment in rabbits after partial hepatectomy: Part II. Laboratory Animals 50(6), 468-475.

Anaesthesia and analgesia in laboratory adult zebrafish: a question of refinement

Anaesthesia is used daily in fish experimental procedures; however, the use of an inadequate anaesthetic protocol can compromise not only the animal's welfare but also the reliability of results. The use of zebrafish (Danio rerio) in biomedical research has increased...

Year Published: 2016Topics: Analgesia, Anesthesia & SedationAnimal Type: Fish, Zebrafish

Citation: Martins, T., Valentim, A. M., Pereira, L. N. et al. 2016. Anaesthesia and analgesia in laboratory adult zebrafish: a question of refinement. Laboratory Animals 50(6), 476-488.

Refinements for embryo implantation surgery in the mouse: Comparison of injectable and inhalant anesthesias – tribromoethanol, ketamine and isoflurane – on pregnancy and pup survival

An essential aspect of genetically-engineered mice (GEM) is the ability to produce live animals after the appropriate injection procedure. Animals are produced by implantation of manipulated embryos into pseudopregnant females for gestation, parturition, and growth to the weaning stage. This...

Year Published: 2016Topics: Anesthesia & Sedation, ReproductionAnimal Type: Mouse, Rodent

Citation: Norton, W. B., Scavizzi, F., Smith, C. D. et al. 2016. Refinements for embryo implantation surgery in the mouse: Comparison of injectable and inhalant anesthesias – tribromoethanol, ketamine and isoflurane – on pregnancy and pup survival. Laboratory Animals 50(5), 335-343.

Olfaction variation in mouse husbandry and its implications for refinement and standardization: UK survey of animal scents

Olfaction plays a crucial role in mouse communication, providing information about genetic identity, physiological status of conspecifics and alerting mice to potential predators. Scents of animal origin can trigger physiological and behavioural responses that could affect experimental responses and impact...

Year Published: 2016Topics: Husbandry & ManagementAnimal Type: Mouse, Rodent

Citation: López-Salesansky, N., Mazlan, N. H., Whitfield, L. E. et al. 2016. Olfaction variation in mouse husbandry and its implications for refinement and standardization: UK survey of animal scents. Laboratory Animals 50(5), 362-369.

Use of the RatLoft decreases pup mortality in lactating mice

Lactating mice in laboratory conditions are thought to be under considerable stress. Dams may manifest this stress through a decrease in milk yield and/or increase in infanticide. The purpose of this study was to examine the effect of access to...

Year Published: 2016Topics: Environmental Enrichment, Rearing & WeaningAnimal Type: Mouse, Rodent

Citation: Weaver, S. R., Cronick, C. M., Prichard, A. P. et al. 2016. Use of the RatLoft decreases pup mortality in lactating mice. Laboratory Animals 50(5), 370-378.

Refinement of habituation procedures in diet-induced obese mice

Orogastric gavage, while a common method for delivering experimental substances in mice, has been shown to induce stress. To minimize the associated stress with this procedure, sham gavage prior to the start of experiment is a common method for habiutating...

Year Published: 2016Topics: Animal Training, Drug/Substance AdministrationAnimal Type: Mouse, Rodent

Citation: Karrberg, L., Andersson, L., Kastenmayer, R. J. et al. 2016. Refinement of habituation procedures in diet-induced obese mice. Laboratory Animals 50(5), 397-399.

Euthanasia using gaseous agents in laboratory rodents

Several questions have been raised in recent years about the euthanasia of laboratory rodents. Euthanasia using inhaled agents is considered to be a suitable aesthetic method for use with a large number of animals simultaneously. Nevertheless, its aversive potential has...

Year Published: 2016Topics: EuthanasiaAnimal Type: Mouse, Rat, Rodent

Citation: Valentim, A. M., Guedes, S. R., Pereira, A. M. et al. 2016. Euthanasia using gaseous agents in laboratory rodents. Laboratory Animals 50(4), 241-253.

Olfactory variation in mouse husbandry and its implications for refinement and standardization: UK survey of non-animal scents

With their highly sensitive olfactory system, the behaviour and physiology of mice are not only influenced by the scents of conspecifics and other species, but also by many other chemicals in the environment. The constraints of laboratory housing limit a...

Year Published: 2016Topics: Husbandry & ManagementAnimal Type: Mouse, Rodent

Citation: López-Salesansky, N., Mazlan, N. H., Whitfield, L. E. et al. 2016. Olfactory variation in mouse husbandry and its implications for refinement and standardization: UK survey of non-animal scents. Laboratory Animals 50(4), 286-295.