Publications

Effects of daily restraint with and without injections on skeletal properties in C57BL/6NHsd mice

Studies typically involve groups of animals that are injected with placebo compounds. As there are studies that demonstrate that restraint and injection can affect behavior and corticosteroid levels in rodents, the basis of such placebo injections is to control for...

Year Published: 2017Topics: Drug/Substance Administration, HandlingAnimal Type: Mouse, Rodent

Citation: Larsen, R. A., Peveler, J. L., Klutzke, J. B. et al. 2017. Effects of daily restraint with and without injections on skeletal properties in C57BL/6NHsd mice. Lab Animal 46(7), 299-301.

A rat-friendly modification of the non-invasive tail-cuff to record blood pressure

In animal models, blood pressure measurement methods can be either invasive (direct) or non-invasive (indirect). The non-invasive alternative involves applying a tail-cuff for blood pressure measurement. Current standardized restraint methods involve confining the laboratory animal in plastic chambers, which can...

Year Published: 2017Topics: Biological Sampling & Physiological Measurement, RestraintAnimal Type: Rat, Rodent

Citation: Lipták, B., Kaprinay, B., Gáspárová, Z. 2017. A rat-friendly modification of the non-invasive tail-cuff to record blood pressure. Lab Animal 46(6), 251-253.

Humane Endpoints website huge success in Spain and the rest of the world

The Humane Endpoints website (https://www.humane-endpoints.info/) provides information and training modules on how to recognize humane endpoints in laboratory animals. This helps to prevent further distress in the animals by removing the animals from the experiment (e.g. euthanizing the animals) or...

Year Published: 2017Topics: Humane EndpointAnimal Type: All/General

Citation: Kliphuis, S. 2017. Humane Endpoints website huge success in Spain and the rest of the world. Laboratory Animals 51(2), 218-219.

PhenoWorld: Addressing animal welfare in a new paradigm to house and assess rat behaviour

The use of animals is essential in biomedical research. The laboratory environment where the animals are housed has a major impact on them throughout their lives and influences the outcome of animal experiments. Therefore, there has been an increased effort...

Year Published: 2017Topics: Environmental Enrichment, HousingAnimal Type: Rat, Rodent

Citation: Castelhano-Carlos, M. J., Baumans, V., Sousa, N. 2017. PhenoWorld: Addressing animal welfare in a new paradigm to house and assess rat behaviour. Laboratory Animals 51(1), 36-43.

Refinement of a model of repeated cerebrospinal fluid collection in conscious rats

The cannulation of the cisterna magna in rats for in vivo sampling of cerebrospinal fluid serves as a valuable model for studying the delivery of new drugs into the central nervous system or disease models. It offers the advantages of...

Year Published: 2017Topics: Biological Sampling & Physiological MeasurementAnimal Type: Rat, Rodent

Citation: Amen, E. M., Brecheisen, M., Sach-Peltason, L. et al. 2017. Refinement of a model of repeated cerebrospinal fluid collection in conscious rats. Laboratory Animals 51(1), 44-53.

Femoral and sciatic nerve blockades and incision site infiltration in rabbits undergoing stifle joint arthrotomy

This study was designed to determine whether perineural injections of local anaesthetics decreases intraoperative nociception and improves postoperative analgesia in New Zealand White rabbits undergoing experimental stifle arthrotomy. All animals were anaesthetized using isoflurane and received morphine intramuscularly. The sciatic...

Year Published: 2017Topics: AnalgesiaAnimal Type: Rabbit

Citation: Kluge, K., Larenza Menzies, M. P., Kloeppel, H. et al. 2017. Femoral and sciatic nerve blockades and incision site infiltration in rabbits undergoing stifle joint arthrotomy. Laboratory Animals 51(1), 54-64.

A less invasive method for orthotopic injection of breast cancer cells into the mouse mammary gland

Breast cancer is the most common type of cancer diagnosed in women, and the second most common cause of cancer-related deaths in women in North America. The use of laboratory mice in research is an essential tool for the study...

Year Published: 2017Topics: Drug/Substance AdministrationAnimal Type: Mouse, Rodent

Citation: Tavera-Mendoza, L. E., Brown, M. 2017. A less invasive method for orthotopic injection of breast cancer cells into the mouse mammary gland. Laboratory Animals 51(1), 85-88.

What the literature tells us about score sheet design

Score sheets are an essential tool of animal welfare. They allow transparent assessments to be made of animal health and behavior during animal experiments and they define interventions when deviations from normal status are detected. As such, score sheets help...

Year Published: 2016Topics: Welfare AssessmentAnimal Type: All/General

Citation: Bugnon, P., Heimann, M., Thallmair, M. 2016. What the literature tells us about score sheet design. Laboratory Animals 50(6), 414-417.

Analgesia in clinically relevant rodent models of sepsis

Postoperative analgesia in rodent sepsis models has been considerably neglected in the past. However, intentions to model clinical practice, increasing awareness of animal ethics, efforts to apply the 3Rs (replacement, reduction, refinement), and stricter legislation argue for a change in...

Year Published: 2016Topics: AnalgesiaAnimal Type: Mouse, Rodent

Citation: Jeger, V., Hauffe, T., Nicholls-Vuille, F. et al. 2016. Analgesia in clinically relevant rodent models of sepsis. Laboratory Animals 50(6), 418-426.

Osteotomy models – the current status on pain scoring and management in small rodents

Fracture healing is a complex regeneration process which produces new bone tissue without scar formation. However, fracture healing disorders occur in approximately 10% of human patients and cause severe pain and reduced quality of life. Recently, the development of more...

Year Published: 2016Topics: Welfare AssessmentAnimal Type: Mouse, Rat, Rodent

Citation: Lang, A., Schulz, A., Ellinghaus, A. et al. 2016. Osteotomy models – the current status on pain scoring and management in small rodents. Laboratory Animals 50(6), 433-441.