Rodent

Longitudinal home-cage automated assessment of climbing behavior shows sexual dimorphism and aging-related decrease in C57BL/6J healthy mice and allows early detection of motor impairment in the N171-82Q mouse model of Huntington’s disease

Monitoring the activity of mice within their home cage is proving to be a powerful tool for revealing subtle and early-onset phenotypes in mouse models. Video-tracking, in particular, lends itself to automated machine-learning technologies that have the potential to improve...

Year Published: 2023Topics: Behavioral & Cognitive Testing, Disease/Experimental Model, HandlingAnimal Type: Mouse, Rodent

Citation: Bains, R. S., Forrest, H., Sillito, R. R. et al. 2023. Longitudinal home-cage automated assessment of climbing behavior shows sexual dimorphism and aging-related decrease in C57BL/6J healthy mice and allows early detection of motor impairment in the N171-82Q mouse model of Huntington's disease. Frontiers in Behavioral Neuroscience 17, 1148172.

Management of naked mole rats (Heterocephalus glaber) at Chester Zoo

This species first arrived at Chester Zoo in June 2014 when a colony of 27 animals was imported from Dresden Zoo, Germany. As with any new species our journey with naked mole rats has not always been straightforward. The early...

Year Published: 2021Topics: Husbandry & ManagementAnimal Type: Mole Rat, Rodent

Citation: Watson, P. 2021. Management of naked mole rats (Heterocephalus glaber) at Chester Zoo. RATEL (Journal of the Association of British and Irish Wild Animal Keepers) 48(3), 24-26.

Handling method affects measures of anxiety, but not chronic stress in mice

Studies in mice have shown that less aversive handling methods (e.g. tunnel or cup handling) can reduce behavioural measures of anxiety in comparison to picking mice up by their tail. Despite such evidence, tail handling continues to be used routinely....

Year Published: 2022Topics: Emotion, Pain, & Sentience, HandlingAnimal Type: Mouse, Rodent

Citation: Novak, J., Jaric, I., Rosso, M. et al. 2022. Handling method affects measures of anxiety, but not chronic stress in mice. Scientific Reports 12(1), 20938.

Enriched environment causes epigenetic changes in hippocampus and improves long-term cognitive function in sepsis

Sepsis is defined as a life-threatening organ dysfunction caused by an inappropriate host response to infection. The presence of oxidative stress and inflammatory mediators in sepsis leads to dysregulated gene expression, leading to a hyperinflammatory response. Environmental conditions play an...

Year Published: 2022Topics: Disease/Experimental Model, Environmental EnrichmentAnimal Type: Rat, Rodent

Citation: Córneo, E., Michels, M., Abatti, M. et al. 2022. Enriched environment causes epigenetic changes in hippocampus and improves long-term cognitive function in sepsis. Scientific Reports 12(1), 11529.

Introduction of gloved hand to cage induces 22-kHz ultrasonic vocalizations in male albino rats

Rodents emit ultrasonic vocalizations (USVs) above the human hearing threshold of ~ 20 kHz to communicate emotional states and to coordinate their social interactive behavior. Twenty-two kHz USVs emitted by adult rats have been reported in a variety of aversive...

Year Published: 2022Topics: Handling, Human-Animal InteractionAnimal Type: Rat, Rodent

Citation: Hwang, S.-K., Tyszkiewicz, C., Dragon, M. et al. 2022. Introduction of gloved hand to cage induces 22-kHz ultrasonic vocalizations in male albino rats. PLOS ONE 17(11), e0278034.

Waking inactivity as a welfare indicator in laboratory mice: Investigating postures, facial expressions and depression-like states

Animal welfare assessment relies on valid and practical indicators of affect. In mice, the most widely used research vertebrates, lying still with eyes open, inactive-but-awake (IBA) in the home cage, has potential to be one such indicator. IBA is elevated...

Year Published: 2022Topics: Emotion, Pain, & Sentience, Welfare AssessmentAnimal Type: Mouse, Rodent

Citation: MacLellan, A., Nazal, B., Young et al. 2022. Waking inactivity as a welfare indicator in laboratory mice: Investigating postures, facial expressions and depression-like states. Royal Society Open Science 9(11), 221083.

Effects of separated pair housing of female C57BL/6JRj mice on well-being

In laboratory animal facilities, it is a common code of practice to house female mice in groups. However, some experimental conditions require to house them individually, even though social isolation may impair their well-being. Therefore, we introduced a separated pair...

Year Published: 2022Topics: Social Housing & CompanionshipAnimal Type: Mouse, Rodent

Citation: Hohlbaum, K., Merle, R., Frahm, S. et al. 2022. Effects of separated pair housing of female C57BL/6JRj mice on well-being. Scientific Reports 12(1), 8819.

Noninvasive three-state sleep-wake staging in mice using electric field sensors

Study Objective: Validate a novel method for sleep-wake staging in mice using noninvasive electric field (EF) sensors. Methods: Mice were implanted with electroencephalogram (EEG) and electromyogram (EMG) electrodes and housed individually. Noninvasive EF sensors were attached to the exterior of...

Year Published: 2020Topics: Biological Sampling & Physiological MeasurementAnimal Type: Mouse, Rodent

Citation: Kloefkorn H, Aiani, L. M., Lakhani, A. et al. 2020. Noninvasive three-state sleep-wake staging in mice using electric field sensors. Journal of Neuroscience Methods 344, 108834.

The use of ball pits and playpens in laboratory Lister Hooded male rats induces ultrasonic vocalisations indicating a more positive affective state and can reduce the welfare impacts of aversive procedures

The advancement and quality of science rely on research that is robust and unbiased in its experimental design, execution, analysis, and reproducibility. In preclinical research, a better understanding of animal emotions and refinement of their husbandry, housing, and handling are...

Year Published: 2022Topics: Environmental EnrichmentAnimal Type: Rat, Rodent

Citation: Hinchcliffe, J. K., Jackson, M. G., Robinson, E. S. 2022. The use of ball pits and playpens in laboratory Lister Hooded male rats induces ultrasonic vocalisations indicating a more positive affective state and can reduce the welfare impacts of aversive procedures. Laboratory Animals 56(4), 370-379.

A review of methods used to kill laboratory rodents: Issues and opportunities

Rodents are the most widely used species for scientific purposes. A critical pre-requisite of their use, based on utilitarian ethical reasoning, is the provision of a humane death when necessary for scientific or welfare grounds. Focussing on the welfare challenges...

Year Published: 2022Topics: EuthanasiaAnimal Type: Mouse, Rat, Rodent

Citation: Clarkson, J. M., Martin, J. E., McKeegan, D. E. F. 2022. A review of methods used to kill laboratory rodents: Issues and opportunities. Laboratory Animals 56(5), 419-436.