Rodent

Infrared thermography for non-invasive measurement of social inequality aversion in rodents and potential usefulness for future animal-friendly studies

Infrared thermography is a method that detects thermal radiation energy and can measure the body surface temperature of animals from a distance. While rectal temperature has traditionally been used to measure animals' core temperature, thermal imaging can avoid the stress...

Year Published: 2023Topics: Biological Sampling & Physiological Measurement, Emotion, Pain, & SentienceAnimal Type: Mouse, Rodent

Citation: Watanabe, S. 2023. Infrared thermography for non-invasive measurement of social inequality aversion in rodents and potential usefulness for future animal-friendly studies. Frontiers in Behavioral Neuroscience 17, 1131427.

A buprenorphine depot formulation provides effective sustained post-surgical analgesia for 72 h in mouse femoral fracture models

Adequate pain management is essential for ethical and scientific reasons in animal experiments and should completely cover the period of expected pain without the need for frequent re-application. However, current depot formulations of Buprenorphine are only available in the USA...

Year Published: 2023Topics: Analgesia, Disease/Experimental ModelAnimal Type: Mouse, Rodent

Citation: Wolter, A., Bucher, C. H., Kurmies, S. et al. 2023. A buprenorphine depot formulation provides effective sustained post-surgical analgesia for 72 h in mouse femoral fracture models. Scientific Reports 13(1), 3824.

Evaluation of parameters which influence voluntary ingestion of supplements in rats

Drug safety and efficacy studies frequently use oral gavage, but repetitive usage may cause problems. Administration through voluntary ingestion represents an opportunity for refinement. We aimed to develop a protocol for voluntary ingestion of gelatin-based supplements in rats, assessing the...

Year Published: 2023Topics: Animal Training, Drug/Substance AdministrationAnimal Type: Rat, Rodent

Citation: Ruvira, S., Rodríguez-Rodríguez, P., Cañas, S. et al. 2023. Evaluation of parameters which influence voluntary ingestion of supplements in rats. Animals 13(11), 1827.

Studying and analyzing humane endpoints in the fructose-fed and streptozotocin-injected rat model of diabetes

This work aimed to define a humane endpoint scoring system able to objectively identify signs of animal suffering in a rat model of type 2 diabetes. Sprague-Dawley male rats were divided into control and induced group. The induced animals drink...

Year Published: 2023Topics: Disease/Experimental Model, Humane Endpoint, Welfare AssessmentAnimal Type: Rat, Rodent

Citation: Silva-Reis, R., Faustino-Rocha, A. I., Silva, J. et al. 2023. Studying and analyzing humane endpoints in the fructose-fed and streptozotocin-injected rat model of diabetes. Animals 13(8), 1397.

Validating in-cage mouse enrichment

There is a wide variety of different types of mouse enrichment currently available, some items of which are more practical than others. Validating items used for providing enrichment can be time consuming and costly, nevertheless it is important to ensure...

Year Published: 2023Topics: Environmental EnrichmentAnimal Type: Mouse, Rodent

Citation: Burbidge, C., Beresford, Z., Serrano-Galleg, V. 2023. Validating in-cage mouse enrichment. Animal Technology and Welfare 22(1), 63–67.

Mouse food hopper dividers for a refined feeding method

This project aimed to establish whether a different method of presenting diet “ad-libitum” to laboratory mice could lower the negative consequences of exceess food, such as decreased quality, palatability and increased cost. The main aim of this project was to...

Year Published: 2022Topics: Husbandry & ManagementAnimal Type: Mouse, Rodent

Citation: Orosz, G. 2022. Mouse food hopper dividers for a refined feeding method. Animal Technology and Welfare 21(3), 160–176.

Longitudinal studies on Alzheimer disease mouse models with multiple tracer PET/CT: Application of reduction and refinement principles in daily practice to safeguard animal welfare during progressive aging

Longitudinal studies on mouse models related to Alzheimer disease (AD) pathology play an important role in the investigation of therapeutic targets to help pharmaceutical research in the development of new drugs and in the attempt of an early diagnosis that...

Year Published: 2023Topics: Disease/Experimental Model, Husbandry & Management, Imaging & Electrophysiological RecordingAnimal Type: Mouse, Rodent

Citation: Palumbo, G., Kunze, L. H., Oos, R. et al. 2023. Longitudinal studies on Alzheimer disease mouse models with multiple tracer PET/CT: Application of reduction and refinement principles in daily practice to safeguard animal welfare during progressive aging. Animals 13(11), 1812.

The rough-and-tumble play of rats as a natural behavior suitable for studying the social brain

Laboratory rats have been an important model species with which to study the neurobiology of rough-and-tumble play (RTP). RTP in rats involves competition to gain access to the partner's nape of the neck, which is nuzzled with the snout if...

Year Published: 2022Topics: Natural Behavior, Social Housing & CompanionshipAnimal Type: Rat, Rodent

Citation: Pellis, S. M., Pellis, V. C., Ham, J. R. et al. 2022. The rough-and-tumble play of rats as a natural behavior suitable for studying the social brain. Frontiers in Behavioral Neuroscience 16, 1033999.

Are currently selected laboratory animals useful in the research of how female hormones influence orthodontic biomechanics?

Animal testing was and remains the only method of introducing a certain treatment and medical procedure on humans. On the other hand, animals have their rights resulting from applicable legal acts, including Directive 2010/63/EU and, indirectly, the World Medical Association...

Year Published: 2023Topics: Disease/Experimental Model, Regulations & Ethical ReviewAnimal Type: All/General, Cat, Rabbit, Rat, Rodent

Citation: Peruga, M., Kawala, B., Sarul, M. et al. 2023. Are currently selected laboratory animals useful in the research of how female hormones influence orthodontic biomechanics? Animals 13(4), 629.

The power of a touch: Regular touchscreen training but not its termination affects hormones and behavior in mice

Touchscreen-based procedures are increasingly used in experimental animal research. They not only represent a promising approach for translational research, but have also been highlighted as a powerful tool to reduce potential experimenter effects in animal studies. However, to prepare the...

Year Published: 2023Topics: Animal Training, Behavioral & Cognitive Testing, Environmental EnrichmentAnimal Type: Mouse, Rodent

Citation: Quante, S. M., Siewert, V., Palme, R. et al. 2023. The power of a touch: Regular touchscreen training but not its termination affects hormones and behavior in mice. Frontiers in Behavioral Neuroscience 17, 1112780.