Rodent

To wheel or not to wheel

Our study into the implementation of running wheels in overweight prone strains of mice and the potential integration of this practice into our mouse protocols.

Year Published: 2023Topics: Environmental EnrichmentAnimal Type: Mouse, Rodent

Citation: Ives, P., Caygill, J. 2023. To wheel or not to wheel. Animal Technology and Welfare 22(3), 246–247.

Evaluation of score parameters for severity assessment of surgery and liver cirrhosis in rats

Severity assessment in animals is an ongoing field of research. In particular, the question of objectifiable and meaningful parameters of score-sheets, as well as their best combination, arise. This retrospective analysis investigates the suitability of a score-sheet for assessing severity...

Year Published: 2023Topics: Welfare AssessmentAnimal Type: Rat, Rodent

Citation: Krueger, J. C., Habigt, M. A., Helmedag, M. J. et al. 2023. Evaluation of score parameters for severity assessment of surgery and liver cirrhosis in rats. Animal Welfare 32, e29.

Tamoxifen exacerbates morbidity and mortality in male mice receiving medetomidine anaesthesia

Tamoxifen-induced CreER-LoxP recombination is often used to induce spatiotemporally controlled gene deletion in genetically modified mice. Prior work has shown that tamoxifen and tamoxifen-induced CreER activation can have off-target effects that should be controlled. However, it has not yet been...

Year Published: 2023Topics: Anesthesia & Sedation, Disease/Experimental ModelAnimal Type: Mouse, Rodent

Citation: Rashbrook, V. S., Denti, L., Ruhrberg, C. 2023. Tamoxifen exacerbates morbidity and mortality in male mice receiving medetomidine anaesthesia. Animal Welfare 32, e78.

Refining the welfare of immunocompromised mice receiving carbon tetrachloride (CCI4) to induce liver fibrosis

Our method provides evidence that we can alter CCI4 dosing and implement recovery techniques to enhance Animal Welfare, whilst maintaining sufficient levels of fibrosis in the liver.

Year Published: 2023Topics: Disease/Experimental ModelAnimal Type: Mouse, Rodent

Citation: Walczak-Gillies, Matthews, O., Fyfe, A. et al. 2023. Refining the welfare of immunocompromised mice receiving carbon tetrachloride (CCI4) to induce liver fibrosis. Animal Technology and Welfare 22(3), 237–239.

Non-invasive assessment of positive affective state using infra-red thermography in rats

With recent increased focus on positive welfare in animal welfare science, there is demand for objective positive welfare indicators. It is unclear whether changes in body surface temperature can be used to non-invasively identify and quantify positive states in mammals....

Year Published: 2023Topics: Welfare AssessmentAnimal Type: Rat, Rodent

Citation: Wongsaengchan, C., McCafferty, D. J., Lennox, K. et al. 2023. Non-invasive assessment of positive affective state using infra-red thermography in rats. Animal Welfare 32, e66.

Measuring ramp use in guinea pigs (Cavia porcellus)

To investigate the utility of ramps as enrichment and as a method for establishing demand for commodities, the latency to climb a ramp of increasing slope to obtain food was measured in four guinea pigs. The average height where guinea...

Year Published: 2022Topics: HousingAnimal Type: Guinea Pig, Rodent

Citation: Begum-Diamond, Z., Neuhauser, J. E., Cameron, K. E. 2022. Measuring ramp use in guinea pigs (Cavia porcellus). Journal of the Experimental Analysis of Behavior 118(2), 292-301.

Rats move nesting materials to create different functional areas: Short report

Here we document how rats separate their living space into different functional regions. Five groups of four female Sprague Dawley rats were housed in caging systems that consisted of two standard cages connected by a tube. Both cages were provided...

Year Published: 2023Topics: Environmental Enrichment, HousingAnimal Type: Rat, Rodent

Citation: Amendola, L., Xu, N., Weary, D. M. 2023. Rats move nesting materials to create different functional areas: Short report. Laboratory Animals 57(1), 75–78.

Getting a handle on rat familiarization: The impact of handling protocols on classic tests of stress in Rattus norvegicus

Experimenter familiarization with laboratory rodents through handling prior to experimentation is an important practice in neurobehavioral research and is implicated in stress, study variability, and replicability. Unfortunately, different handling protocols have not been thoroughly examined. Determining optimal experimenter familiarization protocols...

Year Published: 2023Topics: HandlingAnimal Type: Rat, Rodent

Citation: Bigelow, L. J., Pope, E. K., MacDonald, D. S. et al. 2023. Getting a handle on rat familiarization: The impact of handling protocols on classic tests of stress in Rattus norvegicus. Laboratory Animals 57(3), 259–269.

Mouse isoflurane anesthesia using the drop method

Anesthesia with isoflurane prior to carbon dioxide euthanasia is recommended as a refinement, but vaporizer access can be limited. An alternative to vaporizers is the ‘drop' method, introducing a fixed volume of isoflurane into the induction chamber. Previous work suggests...

Year Published: 2023Topics: Anesthesia & Sedation, EuthanasiaAnimal Type: Mouse, Rodent

Citation: Bodnar, M. J., Ratuski, A. S., Weary, D. M. 2023. Mouse isoflurane anesthesia using the drop method. Laboratory Animals 57(6), 623–630.

Feasibility of pair-housing of rats after cranial implant surgery

Rat models employing cranial implants are increasingly employed to facilitate neural stimulation and recording in freely moving animals. Due to possible damage to wound, implant or attached devices, rats with cranial implants are traditionally housed singly, and little information is...

Year Published: 2023Topics: External Bodily Equipment, Social Housing & CompanionshipAnimal Type: Rat, Rodent

Citation: Evers, J., Sridhar, K., Lowery, M. 2023. Feasibility of pair-housing of rats after cranial implant surgery. Laboratory Animals 57(1), 69–74.