Rat

A review on experimental surgical models and anesthetic protocols of heart failure in rats

Heart failure (HF) is a serious health and economic burden worldwide, and its prevalence is continuously increasing. Current medications effectively moderate the progression of symptoms, and there is a need for novel preventative and reparative treatments. The development of novel...

Year Published: 2023Topics: Anesthesia & Sedation, Disease/Experimental ModelAnimal Type: Rat, Rodent

Citation: Farag, A., Mandour, A. S., Hendawy, H. et al. 2023. A review on experimental surgical models and anesthetic protocols of heart failure in rats. Frontiers in Veterinary Science 10, 1103229.

Camera-based respiration monitoring of unconstrained rodents

Animal research has always been crucial for various medical and scientific breakthroughs, providing information on disease mechanisms, genetic predisposition to diseases, and pharmacological treatment. However, the use of animals in medical research is a source of great controversy and ongoing...

Year Published: 2023Topics: Biological Sampling & Physiological MeasurementAnimal Type: Rat, Rodent

Citation: Breuer, L., Mösch, L., Kunczik, J. et al. 2023. Camera-based respiration monitoring of unconstrained rodents. Animals 13(12), 1901.

Rat’s response to a novelty and increased complexity of the environment resulting from the introduction of movable vs

Most animals, including rats, show a preference for more complex environments. This is demonstrated particularly well when complexity increases due to the addition of new elements to the environment. The aim of the study was to investigate the reaction to...

Year Published: 2022Topics: Environmental EnrichmentAnimal Type: Rat, Rodent

Citation: Chrzanowska, A., Modlinska, K., Goncikowska, K. et al. 2022. Rat's response to a novelty and increased complexity of the environment resulting from the introduction of movable vs. stationary objects in the free exploration test. PLOS ONE 17(12), e0279006.

Animal welfare considerations when conducting OECD test guideline inhalation and toxicokinetic studies for nanomaterials

The OECD test guidelines for animal experiments play an important role in evaluating the chemical hazards. Animal tests performed using OECD guidelines, especially when the good laboratory practice (GLP) principle is applied, reduce the duplication of toxicity testing and ensure...

Year Published: 2022Topics: Disease/Experimental ModelAnimal Type: All/General, Rat, Rodent

Citation: Chung, Y. H., Gulumian, M., Pleus, R. C. et al. 2022. Animal welfare considerations when conducting OECD test guideline inhalation and toxicokinetic studies for nanomaterials. Animals 12(23), 3305.

Review of rat (Rattus norvegicus), Mouse (Mus musculus), Guinea pig (Cavia procellus), and rabbit (Oryctolagus cuniculus) indicators for welfare assessment

The monitoring and assessment of animals is important for their health and welfare. The appropriate selection of multiple, validated, and feasible welfare assessment indicators is required to effectively identify compromises or improvements to animal welfare. Animal welfare indicators can be...

Year Published: 2023Topics: Welfare AssessmentAnimal Type: Guinea Pig, Mouse, Rabbit, Rat, Rodent

Citation: Cohen, S., Ho, C. 2023. Review of rat (Rattus norvegicus), Mouse (Mus musculus), Guinea pig (Cavia procellus), and rabbit (Oryctolagus cuniculus) indicators for welfare assessment. Animals 13(13), 2167.

Enriched environment causes epigenetic changes in hippocampus and improves long-term cognitive function in sepsis

Sepsis is defined as a life-threatening organ dysfunction caused by an inappropriate host response to infection. The presence of oxidative stress and inflammatory mediators in sepsis leads to dysregulated gene expression, leading to a hyperinflammatory response. Environmental conditions play an...

Year Published: 2022Topics: Disease/Experimental Model, Environmental EnrichmentAnimal Type: Rat, Rodent

Citation: Córneo, E., Michels, M., Abatti, M. et al. 2022. Enriched environment causes epigenetic changes in hippocampus and improves long-term cognitive function in sepsis. Scientific Reports 12(1), 11529.

Sex differences in 50 kHz call subtypes emitted during tickling-induced playful behaviour in rats

‘Tickling' induces positive affective states in laboratory rats as evidenced by the production of 50-kHz ultrasonic vocalisations (USVs), although this has mostly been investigated in males. Juvenile rats emit distinctive 50-kHz USV subtypes. Frequency-modulated (FM) 50-kHz USVs are thought to...

Year Published: 2022Topics: VocalizationAnimal Type: Rat, Rodent

Citation: Tivey, E. K. L., Martin, J. E., Brown, S. M. et al. 2022. Sex differences in 50 kHz call subtypes emitted during tickling-induced playful behaviour in rats. Scientific Reports 12(1), 15323.

Using restaurant glassware and flatware wash racks for washing water bottles and cage accessories

In the event of an emergency resulting in our automatic watering system being shut off, we identified the need to increase the number of rodent water bottles we have on hand. Once we realized we had a limited number of...

Year Published: 2022Topics: Husbandry & ManagementAnimal Type: Mouse, Rat, Rodent

Citation: Semus, H. 2022. Using restaurant glassware and flatware wash racks for washing water bottles and cage accessories. Laboratory Animal Science Professional 10(4) (July/August), 32-33.

Compressed paper column housing enrichment for Naked Mole-rats

Naked Mole-rats are relative newcomers in the research world. Due to the complexity of their natural subterranean tunneling system, it has been difficult to replicate in the laboratory environment. Housing standards often differ from the hard solidified lateritic loam soils...

Year Published: 2022Topics: Environmental Enrichment, HousingAnimal Type: Rat, Rodent

Citation: Pantophlet, J., McClusky, D. 2022. Compressed paper column housing enrichment for Naked Mole-rats. Laboratory Animal Science Professional 10(5) (September/October), 42-44.

Introduction of gloved hand to cage induces 22-kHz ultrasonic vocalizations in male albino rats

Rodents emit ultrasonic vocalizations (USVs) above the human hearing threshold of ~ 20 kHz to communicate emotional states and to coordinate their social interactive behavior. Twenty-two kHz USVs emitted by adult rats have been reported in a variety of aversive...

Year Published: 2022Topics: Handling, Human-Animal InteractionAnimal Type: Rat, Rodent

Citation: Hwang, S.-K., Tyszkiewicz, C., Dragon, M. et al. 2022. Introduction of gloved hand to cage induces 22-kHz ultrasonic vocalizations in male albino rats. PLOS ONE 17(11), e0278034.