Mouse

The vest-collar as a rodent collar to prevent licking and scratching during experiments

Various types of restraint collars have been used for research animals, and the Elizabethan collar (E-collar) is the most commonly used. However, animals can be choked by the E-collar or they tend to remove it; furthermore, repeated rubbing and scratching...

Year Published: 2016Topics: External Bodily EquipmentAnimal Type: Mouse, Rodent

Citation: Jang, Y., Park, Y. E., Yun, C.-W. et al. 2016. The vest-collar as a rodent collar to prevent licking and scratching during experiments. Laboratory Animals 50(4), 296-304.

A less invasive method for orthotopic injection of breast cancer cells into the mouse mammary gland

Breast cancer is the most common type of cancer diagnosed in women, and the second most common cause of cancer-related deaths in women in North America. The use of laboratory mice in research is an essential tool for the study...

Year Published: 2017Topics: Drug/Substance AdministrationAnimal Type: Mouse, Rodent

Citation: Tavera-Mendoza, L. E., Brown, M. 2017. A less invasive method for orthotopic injection of breast cancer cells into the mouse mammary gland. Laboratory Animals 51(1), 85-88.

Analgesia in clinically relevant rodent models of sepsis

Postoperative analgesia in rodent sepsis models has been considerably neglected in the past. However, intentions to model clinical practice, increasing awareness of animal ethics, efforts to apply the 3Rs (replacement, reduction, refinement), and stricter legislation argue for a change in...

Year Published: 2016Topics: AnalgesiaAnimal Type: Mouse, Rodent

Citation: Jeger, V., Hauffe, T., Nicholls-Vuille, F. et al. 2016. Analgesia in clinically relevant rodent models of sepsis. Laboratory Animals 50(6), 418-426.

Osteotomy models – the current status on pain scoring and management in small rodents

Fracture healing is a complex regeneration process which produces new bone tissue without scar formation. However, fracture healing disorders occur in approximately 10% of human patients and cause severe pain and reduced quality of life. Recently, the development of more...

Year Published: 2016Topics: Welfare AssessmentAnimal Type: Mouse, Rat, Rodent

Citation: Lang, A., Schulz, A., Ellinghaus, A. et al. 2016. Osteotomy models – the current status on pain scoring and management in small rodents. Laboratory Animals 50(6), 433-441.

Morbidity scoring after abdominal surgery

Postoperative monitoring of pain and distress in small rodents is not standardized, and widely accepted score sheets are not available. Here we describe a score sheet used in abdominal surgery of rodents, with particular reference to procedures involving the liver.

Year Published: 2016Topics: Welfare AssessmentAnimal Type: Mouse, Rat, Rodent

Citation: Graf, R., Cinelli, P., Arras, M. 2016. Morbidity scoring after abdominal surgery. Laboratory Animals 50(6), 453-458.

Refinements for embryo implantation surgery in the mouse: Comparison of injectable and inhalant anesthesias – tribromoethanol, ketamine and isoflurane – on pregnancy and pup survival

An essential aspect of genetically-engineered mice (GEM) is the ability to produce live animals after the appropriate injection procedure. Animals are produced by implantation of manipulated embryos into pseudopregnant females for gestation, parturition, and growth to the weaning stage. This...

Year Published: 2016Topics: Anesthesia & Sedation, ReproductionAnimal Type: Mouse, Rodent

Citation: Norton, W. B., Scavizzi, F., Smith, C. D. et al. 2016. Refinements for embryo implantation surgery in the mouse: Comparison of injectable and inhalant anesthesias – tribromoethanol, ketamine and isoflurane – on pregnancy and pup survival. Laboratory Animals 50(5), 335-343.

Olfaction variation in mouse husbandry and its implications for refinement and standardization: UK survey of animal scents

Olfaction plays a crucial role in mouse communication, providing information about genetic identity, physiological status of conspecifics and alerting mice to potential predators. Scents of animal origin can trigger physiological and behavioural responses that could affect experimental responses and impact...

Year Published: 2016Topics: Husbandry & ManagementAnimal Type: Mouse, Rodent

Citation: López-Salesansky, N., Mazlan, N. H., Whitfield, L. E. et al. 2016. Olfaction variation in mouse husbandry and its implications for refinement and standardization: UK survey of animal scents. Laboratory Animals 50(5), 362-369.

Use of the RatLoft decreases pup mortality in lactating mice

Lactating mice in laboratory conditions are thought to be under considerable stress. Dams may manifest this stress through a decrease in milk yield and/or increase in infanticide. The purpose of this study was to examine the effect of access to...

Year Published: 2016Topics: Environmental Enrichment, Rearing & WeaningAnimal Type: Mouse, Rodent

Citation: Weaver, S. R., Cronick, C. M., Prichard, A. P. et al. 2016. Use of the RatLoft decreases pup mortality in lactating mice. Laboratory Animals 50(5), 370-378.

Refinement of habituation procedures in diet-induced obese mice

Orogastric gavage, while a common method for delivering experimental substances in mice, has been shown to induce stress. To minimize the associated stress with this procedure, sham gavage prior to the start of experiment is a common method for habiutating...

Year Published: 2016Topics: Animal Training, Drug/Substance AdministrationAnimal Type: Mouse, Rodent

Citation: Karrberg, L., Andersson, L., Kastenmayer, R. J. et al. 2016. Refinement of habituation procedures in diet-induced obese mice. Laboratory Animals 50(5), 397-399.

Euthanasia using gaseous agents in laboratory rodents

Several questions have been raised in recent years about the euthanasia of laboratory rodents. Euthanasia using inhaled agents is considered to be a suitable aesthetic method for use with a large number of animals simultaneously. Nevertheless, its aversive potential has...

Year Published: 2016Topics: EuthanasiaAnimal Type: Mouse, Rat, Rodent

Citation: Valentim, A. M., Guedes, S. R., Pereira, A. M. et al. 2016. Euthanasia using gaseous agents in laboratory rodents. Laboratory Animals 50(4), 241-253.