Mouse

Automated and continuous monitoring of animal welfare through digital alerting

A primary goal in preclinical animal research is respectful and responsible care aimed toward minimizing stress and discomfort while enhancing collection of accurate and reproducible scientific data. Researchers use hands-on clinical observations and measurements as part of routine husbandry procedures...

Year Published: 2020Topics: Disease/Experimental Model, Humane Endpoint, Welfare AssessmentAnimal Type: Mouse, Rat, Rodent

Citation: Do, J. P., Defensor, E. B., Ichim, C. V. et al. 2020. Automated and continuous monitoring of animal welfare through digital alerting. Comparative Medicine 70(4), 313-327.

Improving animal welfare at Newcastle University by introducing the low stress handling of mice

The primary focus of this project was to introduce the low stress handling of mice to Newcastle University and resulting in all researchers and technicians using this method. It aimed to bring a team together, working to promote and communicate...

Year Published: 2020Topics: HandlingAnimal Type: Mouse, Rodent

Citation: Hamilton, E. 2020. Improving animal welfare at Newcastle University by introducing the low stress handling of mice. Animal Technology and Welfare 19(3), 185-194.

Alternative training method using a mouse simulator in intravenous lateral tail vein procedures

The purpose of this study was to reduce or replace mouse cadavers for use in procedural training. All participants had mixed experience in various technical procedures such as oral gavage, intraperitoneal injections, etc., but none had ever carried out intravenous...

Year Published: 2020Topics: Biological Sampling & Physiological MeasurementAnimal Type: Mouse, Rodent

Citation: Abela, C. 2020. Alternative training method using a mouse simulator in intravenous lateral tail vein procedures. Animal Technology and Welfare 19(3), 249-250.

Quantification of hair corticosterone, DHEA and testosterone as a potential tool for welfare assessment in male laboratory mice

Steroids, providing information regarding several biological patterns including stress and sexual behavior, have been investigated in different matrices in laboratory mice. Data regarding hair quantification, indicative of longer timespans when compared to blood and saliva, are lacking. The aim of...

Year Published: 2020Topics: Biological Sampling & Physiological Measurement, Welfare AssessmentAnimal Type: Mouse, Rodent

Citation: Elmi, A., Galligioni, V., Govoni, N. et al. 2020. Quantification of hair corticosterone, DHEA and testosterone as a potential tool for welfare assessment in male laboratory mice. Animals 10(12), 2408.

Comparison of pre-emptive butorphanol or metamizole with ketamine +medetomidine and s-ketamine + medetomidine anaesthesia in improving intraoperative analgesia in mice

In accordance with the ‘refinement' component of the 3Rs, the primary aim of this study was to investigate and compare ketamine + medetomidine (KM) and s-ketamine + medetomidine (SKM) anaesthetic protocols in C57BL/6J mice (both sexes). We sought to determine whether s-ketamine could provide...

Year Published: 2019Topics: Analgesia, Anesthesia & SedationAnimal Type: Mouse, Rodent

Citation: Bauer, C., Schillinger, U., Brandl, J. et al. 2019. Comparison of pre-emptive butorphanol or metamizole with ketamine +medetomidine and s-ketamine + medetomidine anaesthesia in improving intraoperative analgesia in mice. Laboratory Animals 53(5), 459–469.

Implementing strategies to reduce singly housed male mice

There are different husbandry situations that lead to social isolation of male mice. Besides legal considerations, single housing has a negative impact on behavioural and molecular studies. We have implemented two strategies, the ‘companion mouse' and just-weaned male grouping, to...

Year Published: 2019Topics: Social Housing & CompanionshipAnimal Type: Mouse, Rodent

Citation: Azkona, G., Caballero, J. M. 2019. Implementing strategies to reduce singly housed male mice. Laboratory Animals 53(5), 508–510.

Fasting of male mice – Effects of time point of initiation and duration on clinical chemistry parameters and animal welfare

Fasting of mice is a common procedure, which can affect the outcome of the study as well as animal welfare. In this study, we assess the effects of fasting, fasting duration and fasting initiation time in relation to light schedule...

Year Published: 2019Topics: Disease/Experimental Model, Husbandry & ManagementAnimal Type: Mouse, Rodent

Citation: Jensen, T. L., Kiersgaard, M. K., Mikkelsen, L. F. et al. 2019. Fasting of male mice – Effects of time point of initiation and duration on clinical chemistry parameters and animal welfare. Laboratory Animals 53(6), 587–597.

Attempting enrichment harmonization across multiple sites and embracing our differences

A glabal enrichment committee incorporates active members from each of the company's 6 sites and works towards harmonization of enrichment practices. One of the hot topics is attempting to standardize mouse enrichment and social housing practices. This has proven to...

Year Published: 2018Topics: Environmental Enrichment, Social Housing & CompanionshipAnimal Type: Mouse, Rodent

Citation: Allen, C., Duggan, L., Fox, M. et al. 2018. Attempting enrichment harmonization across multiple sites and embracing our differences. Laboratory Animal Science Professional 5(4) (December), 48-51.

Fight Club: Using housing conditions to curb male cage aggression

Those who have worked with C57BL/6 males know how aggressive they can be towards their cage mates. We poured over academic journals, reading every article we could find regarding male home cage aggression. Three articles piqued our interest and suggested...

Year Published: 2019Topics: Environmental Enrichment, Social Housing & CompanionshipAnimal Type: Mouse, Rodent

Citation: Sherrill, C., Kavanagh, K. 2019. Fight Club: Using housing conditions to curb male cage aggression. Laboratory Animal Science Professional 7(1) (March), 38-40.

Use of more naturalistic nesting material helps decrease food shredding in mice

Shredding of feed (food grinding or food wasting) is a common behavior among certain strains of mice. It is seen in both captive and wild rodents and may either be an abnormal behavior or a normal behavior that is simply...

Year Published: 2019Topics: Environmental EnrichmentAnimal Type: Mouse, Rodent

Citation: MacDuff, A., Loera, F., Adamson, T. W. 2019. Use of more naturalistic nesting material helps decrease food shredding in mice. Laboratory Animal Science Professional 7(1) (March), 46-48.