Mouse

Evaluation of various IVC systems according to mouse reproductive performance and husbandry and environmental parameters

IVC systems are marketed for improving the health and management of mouse colonies. The current study compared mouse reproductive performance and husbandry and environmental parameters among 3 high-density (HD) IVC rack systems (RS1, RS2, and RS3), which were present in...

Year Published: 2022Topics: HousingAnimal Type: Mouse, Rodent

Citation: Stover, M. G., Villano, J. S. 2022. Evaluation of various IVC systems according to mouse reproductive performance and husbandry and environmental parameters. JAALAS 61(1), 31-41.

Behavioral and physiologic effects of dirty bedding exposure in female ICR mice

Exposure of sentinel mice to dirty bedding is commonly used in health monitoring programs to screen colonies for clinical and subclinical disease. Despite the potential stressors present in dirty bedding, including but not limited to microorganisms, pheromones, and ammonia, it...

Year Published: 2022Topics: Husbandry & ManagementAnimal Type: Mouse, Rodent

Citation: Merley, A. L., Hubbard, J. S., Rendahl, A. K. et al. 2022. Behavioral and physiologic effects of dirty bedding exposure in female ICR mice. JAALAS 61(1), 42-51.

Comparison of gelatin flavors for oral dosing of C57BL/6J and FVB/N mice

Precise oral dosing in rodents is usually achieved by intragastric gavage. If performed incorrectly due to technical difficulties, inexperience, or animal resistance, oral gavage may have animal welfare implications such as esophageal and gastric rupture and aspiration. The stress that...

Year Published: 2022Topics: Drug/Substance AdministrationAnimal Type: Mouse, Rodent

Citation: Martins, T., Matos, A. F., Soares, J. et al. 2022. Comparison of gelatin flavors for oral dosing of C57BL/6J and FVB/N mice. JAALAS 61(1), 89-95.

Performance and consistency of circulating warm water blankets for rodents

General anesthesia as used for rodent research can have adverse effects on physiologic mechanisms. Thermoregulation is often greatly inhibited, with resultant deleterious effects on cardiac and respiratory function. These potential effects can be mitigated by providing external heat support. The...

Year Published: 2022Topics: Surgery & Post-OpAnimal Type: Chinchilla, Gerbil, Guinea Pig, Hamster, Mouse, Other Rodent, Rat, Rodent

Citation: Nicolis, I. N., Beale, C. N., Bidot, W. A. et al. 2022. Performance and consistency of circulating warm water blankets for rodents. JAALAS 61(1), 96-100.

Short-term housing in metabolic caging on measures of energy and fluid balance in male C57BL/6J mice (Mus musculus)

Metabolic caging is an important tool for quantitative urine and feces collection in rodents, although significant limitations and problems accompany its use. Despite strong opinions among investigators regarding the effects of metabolic caging on energy and fluid homeostasis, careful quantitative...

Year Published: 2022Topics: HousingAnimal Type: Mouse, Rodent

Citation: Ziegler, A. A., Grobe, C. C., Reho, J. J. et al. 2022. Short-term housing in metabolic caging on measures of energy and fluid balance in male C57BL/6J mice (Mus musculus). JAALAS 61(2), 132-139.

Environmental enrichment for rats and mice housed in laboratories: A metareview

Environmental enrichment has been widely studied in rodents, but there is no consensus on what enrichment should look like or what it should achieve. Inconsistent use of the term “enrichment” creates challenges in drawing conclusions about the quality of an...

Year Published: 2022Topics: Environmental EnrichmentAnimal Type: Mouse, Rat, Rodent

Citation: Ratuski, A. S., Weary, D. M. 2022. Environmental enrichment for rats and mice housed in laboratories: A metareview. Animals 12(4), 414.

Introducing non-aversive mouse handling with ‘squnnels’ in a mouse breeding facility

Based on queries received during our 2021 LASA 3Rs' presentation, we describe operational highlights and concerns that came up during the rollout of nonaversive handling as standard of care at our mouse breeding facility. We describe the development of the...

Year Published: 2022Topics: HandlingAnimal Type: Mouse, Rodent

Citation: Reynolds, P. S. 2022. Introducing non-aversive mouse handling with ‘squnnels' in a mouse breeding facility. Animal Technology and Welfare 21(1), 42-45.

Titrating the preferences of altered lighting against temperature in female CD-1 laboratory mice, Mus musculus

Aspects of the laboratory are aversive to mice, such as being housed under bright lights and at temperatures below their thermal comfort, causing stress and poor welfare. While murine thermal preferences are well understood, light preferences in mice are under...

Year Published: 2022Topics: Husbandry & ManagementAnimal Type: Mouse, Rodent

Citation: Davis, H. J., Barabas, A. J., Gaskill, B. N. 2022. Titrating the preferences of altered lighting against temperature in female CD-1 laboratory mice, Mus musculus. Applied Animal Behaviour Science 246, 105541.

Why does lifelong conventional housing reduce the sociability of female mice?

Compared to peers raised in well-resourced, 'enriched' environments (‘EE'), female laboratory mice from conventional barren cages are more aggressive to their cage-mates, and less sociable with familiar non-cage-mates (especially if these too are from conventional housing, ‘CH'). But how do...

Year Published: 2022Topics: Housing, Social Housing & CompanionshipAnimal Type: Mouse, Rodent

Citation: Kitchenham, L., Nazal, B., Adcock, A. et al. 2022. Why does lifelong conventional housing reduce the sociability of female mice? Applied Animal Behaviour Science 246, 105532.

Effects of multimodal analgesic protocol, with buprenorphine and meloxicam, on mice well-being: A dose finding study

The anesthetic or analgesic agent of choice, route and frequency of anesthetic or analgesic administration, and stressors induce distress during the perioperative period. We evaluated a multimodal analgesic protocol using buprenorphine and meloxicam on the well-being of mice. Twenty-four Slc:ICR...

Year Published: 2021Topics: AnalgesiaAnimal Type: Mouse, Rodent

Citation: Furumoto, K., Ogita, K., Kamisaka, T. et al. 2021. Effects of multimodal analgesic protocol, with buprenorphine and meloxicam, on mice well-being: A dose finding study. Animals 11(12), 3420.