Mouse

Behavioral Biology of Laboratory Animals

This 30-chapter volume informs students and professionals about the behavioral biology of animals commonly housed in laboratory and other captive settings. Each species evolved under specific environmental conditions, resulting in unique behavioral patterns, many of which are maintained in captivity...

Year Published: 2022Topics: Abnormal/Problematic Behavior, Animal Training, Environmental Enrichment, Handling, Housing, Human-Animal Interaction, Husbandry & Management, Natural Behavior, Rearing & Weaning, Social Housing & Companionship, Welfare AssessmentAnimal Type: All/General, Amphibian, Baboon, Capuchin, Cat, Cattle, Chicken, Crocodile & Alligator, Dog, Equine, Ferret, Finch, Fish, Fowl, Frog & Toad, Gerbil, Guinea Pig, Hamster, Lizard, Macaque, Marmoset, Mouse, Nonhuman Primate, Other Rodent, Owl Monkey, Pig, Rabbit, Rat, Reptile, Rodent, Salamander, Sheep, Snake, Squirrel Monkey, Turtle & Tortoise, Vervet (African Green Monkey), Zebrafish

Citation: Coleman, K., Schapiro, S. J. (Eds.) 2022. Behavioral Biology of Laboratory Animals (1st Ed.). CRC Press, Boca Raton, FL, 560 p.

Wound localization and housing conditions dictate repair dynamics and scar formation

Wound healing is a highly orchestrated process involving diverse cells and molecular interplays. Although wound healing assays are commonly used in the field of tissue repair, these experiments exhibit high variability due to their multifactorial nature, with many design factors...

Year Published: 2025Topics: Disease/Experimental Model, Social Housing & CompanionshipAnimal Type: Mouse, Rodent

Citation: Yampolsky, M., Bachelet, I., Fuchs, Y. 2025. Wound localization and housing conditions dictate repair dynamics and scar formation. Lab Animal 54(3), 68–73.

Inconsistent terminology in rodent anatomy hinders appropriate blood sampling in laboratory animal science: A review of blood sampling techniques on the head of mice

Blood sampling is often performed during animal studies. This is more challenging in mice than in larger animal species owing to their size and lack of blood vessel visibility. Guidelines for blood sampling in mice and papers on animal welfare...

Year Published: 2025Topics: Biological Sampling & Physiological MeasurementAnimal Type: Mouse, Rodent

Citation: Štrbenc, M. 2025. Inconsistent terminology in rodent anatomy hinders appropriate blood sampling in laboratory animal science: A review of blood sampling techniques on the head of mice. Laboratory Animals 59(3), 332–341.

Mouse strain-specific habituation to oral metamizole administration

When pain might occur during an animal experiment, sufficient analgesia is necessary. Metamizole is the third most used postoperative pain medication in animal research. The analgesic effect of metamizole is supposed to last 6–8 h in rodents. Therefore, the supplementation of...

Year Published: 2025Topics: Drug/Substance AdministrationAnimal Type: Mouse, Rodent

Citation: Schreiber, T., Leitner, E., Brandstetter, J. et al. 2025. Mouse strain-specific habituation to oral metamizole administration. Laboratory Animals 59(2), 192–202.

Breeding planning for laboratory mice

In laboratory animal facilities, due to the rules of mammalian genetics, animals are often produced that do not possess the required genotype for planned experiments. To minimize the number of these animals that cannot be used for the intended research,...

Year Published: 2025Topics: ReproductionAnimal Type: Mouse, Rodent

Citation: Schenkel, J., Nagel-Riedasch, S., Zevnik, B. et al. 2025. Breeding planning for laboratory mice. Laboratory Animals 59(3), 415–415.

Current practices of pain assessment and analgesic use in laboratory mice: A 2022 FELASA Working Group survey

Assessing and alleviating pain in animals involved in research is critically important. However, the effective implementation of pain management depends on the knowledge and attitudes of the personnel involved. Following a Federation of European Laboratory Animal Science Associations ‘Pain in...

Year Published: 2025Topics: Analgesia, Welfare AssessmentAnimal Type: Mouse, Rodent

Citation: Gomez de Segura, I. A., Seeldrayers, S., Flecknell, P. 2025. Current practices of pain assessment and analgesic use in laboratory mice: A 2022 FELASA Working Group survey. Laboratory Animals 59(3), 396–412.

Mouse aversion to induction with isoflurane using the drop method

Isoflurane anesthesia prior to carbon dioxide euthanasia is recognized as a refinement by many guidelines. Facilities lacking access to a vaporizer can use the “drop” method, whereby liquid anesthetic is introduced into an induction chamber. Knowing the least aversive concentration...

Year Published: 2025Topics: EuthanasiaAnimal Type: Mouse, Rodent

Citation: Bodnar, M. J., Makowska, I. J., Boyd, C. T. et al. 2025. Mouse aversion to induction with isoflurane using the drop method. Laboratory Animals 59(2), 169–177.

Environmental enrichment attenuates reproductive adversity in a mouse model of Parkinson disease

Environmental enrichment is the provision of different substrates to mimic an animal’s natural environment and encourage natural, species-specific behavior. However, the use of enrichment to improve breeding efficiency in mouse models for neurologic conditions is not well described. There are...

Year Published: 2025Topics: Environmental Enrichment, ReproductionAnimal Type: Mouse, Rodent

Citation: Walsh, C. A., Johnson, L., Cirillo, P. A. et al. 2025. Environmental enrichment attenuates reproductive adversity in a mouse model of parkinson disease. Journal of the American Association for Laboratory Animal Science 64(1), 58–63.

Hypothermia as a sole euthanasia method for neonatal mice (Mus musculus)

Per the AVMA euthanasia guidelines, there are no data supporting the use of hypothermia as a solitary method of euthanasia for neonatal mice. However, the use of a secondary physical method of euthanasia, such as decapitation, could be time-consuming and...

Year Published: 2025Topics: EuthanasiaAnimal Type: Mouse, Rodent

Citation: Tang, N.-K., Theil, J. H., Oates, R. S. 2025. Hypothermia as a sole euthanasia method for neonatal mice (Mus musculus). Journal of the American Association for Laboratory Animal Science 64(3), 500–506.

Gavage-needle voluntary consumption administration of a dose-specific measure to mice (Mus musculus)

Orogastric gavage is a common technique used to administer test articles to rodents with risks ranging from increased stress to death of the animal. In this study, we propose a novel technique to administer treatments to mice for voluntary consumption...

Year Published: 2025Topics: Drug/Substance AdministrationAnimal Type: Mouse, Rodent

Citation: Punger, E. M., Norris, S. L., Stevens, S. C. et al. 2025. Gavage-needle voluntary consumption administration of a dose-specific measure to mice (Mus musculus). Journal of the American Association for Laboratory Animal Science 64(2), 287–293.