Drug/Substance Administration

Effects of positive reinforcement training for heifers on responses to a subcutaneous injection

Cattle are subjected to routine procedures that require restraint and close contact to humans, which are both potentially aversive to the animal. Positive reinforcement training techniques may affect how animals perceive and respond to these procedures. The objectives of the...

Year Published: 2021Topics: Animal Training, Drug/Substance AdministrationAnimal Type: Cattle

Citation: Lomb, J., Mauger, A., von Keyserlingk, M. A. G. et al. 2021. Effects of positive reinforcement training for heifers on responses to a subcutaneous injection. Journal of Dairy Science 104(5), 6146-6158.

Intramuscular vs. intradermic needle-free vaccination in piglets: Relevance for animal welfare based on an aversion learning test and vocalizations.

The aim of the present study was to compare intramuscular injection with a needle and intradermic needle-free vaccinations against porcine reproductive and respiratory syndrome (PRRS) in piglets at 28 days old by studying behavioral and physiological reactions. A total of...

Year Published: 2021Topics: Drug/Substance AdministrationAnimal Type: Pig

Citation: Dalmau, A., Sánchez-Matamoros, A., Molina, J. M. et al. 2021. Intramuscular vs. intradermic needle-free vaccination in piglets: Relevance for animal welfare based on an aversion learning test and vocalizations. Frontiers in Veterinary Science 8, 715260.

Emulsified gels: A refined vehicle for accurate and rapid oral administration of lipid based preparations to rats

Oro-gastric gavage is used to accurately administer nutritional substances or drugs to animals. However, it induces stress and has a substantial risk of mishap. Incorporation into edible gels is difficult for lipid-based preparations. We report a new methodology for producing...

Year Published: 2021Topics: Drug/Substance AdministrationAnimal Type: Rat, Rodent

Citation: Satokar, V., Vickers, M., Bridge-Comer, P. et al. 2021. Emulsified gels: A refined vehicle for accurate and rapid oral administration of lipid based preparations to rats. Animal Technology and Welfare 20(2), 95-103.

Comparison of pain response after subcutaneous injection of two maropitant formulations to beagle dogs

The antiemetic maropitant, with metacresol as preservative (Cerenia, Zoetis), has been associated with pain after subcutaneous injection in dogs and cats. Recently, a generic formulation containing benzyl alcohol was authorised (Prevomax, Le Vet). Benzyl alcohol is reported to have local...

Year Published: 2018Topics: Drug/Substance AdministrationAnimal Type: Dog

Citation: Deckers, N., Ruigrok, C. A., Verhoeve, H. P. et al. 2018. Comparison of pain response after subcutaneous injection of two maropitant formulations to beagle dogs. Veterinary Record Open 5(1), e000262.

Voluntary oral administration of drugs in mice

Oral administration of substances is a common procedure in scientific experiments using laboratory animals and typically is achieved in conscious animals by using the intragastric gavage technique. While highly effective, this method can be technically challenging particularly in small animals...

Year Published: 2011Topics: Drug/Substance AdministrationAnimal Type: Mouse, Rodent

Citation: Zhang, L. 2011. Voluntary oral administration of drugs in mice. Protocol Exchange [version 1, protocol preprint].

Alternative method of oral dosing for rats

Oral administration of drugs to laboratory rodents typically is achieved by using the gavage technique. Although highly effective, this method occasionally can cause esophageal injury as well as restraint-associated distress, particularly with repeated use. The aim of this study was...

Year Published: 2010Topics: Drug/Substance AdministrationAnimal Type: Rat, Rodent

Citation: Atcha, Z., Rourke, C., Neo, A. H. P. et al. 2010. Alternative method of oral dosing for rats. JAALAS 49(3), 335-343.

A once-per-day, drug-in-food protocol for prolonged administration of antiepileptic drugs in animal models

Purpose: Convenient and effective methods for administering potential antiepileptic drugs (AEDs) chronically should facilitate many experiments in animal models of chronic epilepsy with spontaneous recurrent seizures. This proof-of-principle study aimed to optimize a once-per-day, drug-in-food protocol by testing the effect...

Year Published: 2012Topics: Drug/Substance AdministrationAnimal Type: Rat, Rodent

Citation: Ali, A., Dua, Y., Constance, J. E. et al. 2012. A once-per-day, drug-in-food protocol for prolonged administration of antiepileptic drugs in animal models. Epilepsia 53(1), 199-206.

Comparison of the effects of osmotic pump implantation with subcutaneous injection for administration of drugs after total body irradiation in mice

The increasing potential for radiation exposure from nuclear accidents or terrorist activities has intensified the need to develop pharmacologic countermeasures against injury from total body irradiation (TBI). Many initial experiments to develop and test these countermeasures utilize murine irradiation models....

Year Published: 2021Topics: Cannulation, Catheterization, & Intubation, Disease/Experimental Model, Drug/Substance AdministrationAnimal Type: Mouse, Rodent

Citation: Koch, A. L., Rusnak, M., Peachee, K. et al. 2021. Comparison of the effects of osmotic pump implantation with subcutaneous injection for administration of drugs after total body irradiation in mice. Laboratory Animals 55(2), 142-149.

Use of food enrichment for medication delivery in large groups of sheep

In a 2018 AALAS webinar on Sheep and Goat Analgesia, Dr. Susie Vogel, a small ruminant expert, introduced the concept of getting sheep and goats to willingly take medication by putting it in a tasty food treat. I had doubts...

Year Published: 2021Topics: Analgesia, Animal Training, Drug/Substance AdministrationAnimal Type: Sheep

Citation: Wilson-Welder, J. H., Frank, A. T. 2021. Use of food enrichment for medication delivery in large groups of sheep. Laboratory Animal Science Professional 9(3) (May/June), 40-43.

Refining dosing by oral gavage in the dog: A protocol to harmonise welfare

Introduction: The dog is a frequently-used, non-rodent species in the safety assessment of new chemical entities. We have a scientific and ethical obligation to ensure that the best quality of data is achieved from their use. Oral gavage is a...

Year Published: 2015Topics: Drug/Substance AdministrationAnimal Type: Dog

Citation: Hall, L. E., Robinson, S., Buchanan-Smith, H. E. 2015. Refining dosing by oral gavage in the dog: A protocol to harmonise welfare. Journal of Pharmacological and Toxicological Methods 72, 35-46.