Drug/Substance Administration

Comparison of pain response after subcutaneous injection of two maropitant formulations to beagle dogs

The antiemetic maropitant, with metacresol as preservative (Cerenia, Zoetis), has been associated with pain after subcutaneous injection in dogs and cats. Recently, a generic formulation containing benzyl alcohol was authorised (Prevomax, Le Vet). Benzyl alcohol is reported to have local...

Year Published: 2018Topics: Drug/Substance AdministrationAnimal Type: Dog

Citation: Deckers, N., Ruigrok, C. A., Verhoeve, H. P. et al. 2018. Comparison of pain response after subcutaneous injection of two maropitant formulations to beagle dogs. Veterinary Record Open 5(1), e000262.

Voluntary oral administration of drugs in mice

Oral administration of substances is a common procedure in scientific experiments using laboratory animals and typically is achieved in conscious animals by using the intragastric gavage technique. While highly effective, this method can be technically challenging particularly in small animals...

Year Published: 2011Topics: Drug/Substance AdministrationAnimal Type: Mouse, Rodent

Citation: Zhang, L. 2011. Voluntary oral administration of drugs in mice. Protocol Exchange [version 1, protocol preprint].

Alternative method of oral dosing for rats

Oral administration of drugs to laboratory rodents typically is achieved by using the gavage technique. Although highly effective, this method occasionally can cause esophageal injury as well as restraint-associated distress, particularly with repeated use. The aim of this study was...

Year Published: 2010Topics: Drug/Substance AdministrationAnimal Type: Rat, Rodent

Citation: Atcha, Z., Rourke, C., Neo, A. H. P. et al. 2010. Alternative method of oral dosing for rats. JAALAS 49(3), 335-343.

A once-per-day, drug-in-food protocol for prolonged administration of antiepileptic drugs in animal models

Purpose: Convenient and effective methods for administering potential antiepileptic drugs (AEDs) chronically should facilitate many experiments in animal models of chronic epilepsy with spontaneous recurrent seizures. This proof-of-principle study aimed to optimize a once-per-day, drug-in-food protocol by testing the effect...

Year Published: 2012Topics: Drug/Substance AdministrationAnimal Type: Rat, Rodent

Citation: Ali, A., Dua, Y., Constance, J. E. et al. 2012. A once-per-day, drug-in-food protocol for prolonged administration of antiepileptic drugs in animal models. Epilepsia 53(1), 199-206.

Comparison of the effects of osmotic pump implantation with subcutaneous injection for administration of drugs after total body irradiation in mice

The increasing potential for radiation exposure from nuclear accidents or terrorist activities has intensified the need to develop pharmacologic countermeasures against injury from total body irradiation (TBI). Many initial experiments to develop and test these countermeasures utilize murine irradiation models....

Year Published: 2021Topics: Cannulation, Catheterization, & Intubation, Disease/Experimental Model, Drug/Substance AdministrationAnimal Type: Mouse, Rodent

Citation: Koch, A. L., Rusnak, M., Peachee, K. et al. 2021. Comparison of the effects of osmotic pump implantation with subcutaneous injection for administration of drugs after total body irradiation in mice. Laboratory Animals 55(2), 142-149.

Use of food enrichment for medication delivery in large groups of sheep

In a 2018 AALAS webinar on Sheep and Goat Analgesia, Dr. Susie Vogel, a small ruminant expert, introduced the concept of getting sheep and goats to willingly take medication by putting it in a tasty food treat. I had doubts...

Year Published: 2021Topics: Analgesia, Animal Training, Drug/Substance AdministrationAnimal Type: Sheep

Citation: Wilson-Welder, J. H., Frank, A. T. 2021. Use of food enrichment for medication delivery in large groups of sheep. Laboratory Animal Science Professional 9(3) (May/June), 40-43.

Refining dosing by oral gavage in the dog: A protocol to harmonise welfare

Introduction: The dog is a frequently-used, non-rodent species in the safety assessment of new chemical entities. We have a scientific and ethical obligation to ensure that the best quality of data is achieved from their use. Oral gavage is a...

Year Published: 2015Topics: Drug/Substance AdministrationAnimal Type: Dog

Citation: Hall, L. E., Robinson, S., Buchanan-Smith, H. E. 2015. Refining dosing by oral gavage in the dog: A protocol to harmonise welfare. Journal of Pharmacological and Toxicological Methods 72, 35-46.

Predictors of subcutaneous injection site reactions to sustained-release buprenorphine in rhesus macaques (Macaca mulatta)

Subcutaneous injection site reactions to sustained-release buprenorphine hydrochloride (Buprenorphine SR) in macaques have been reported in only a single case report. In the current study, we evaluated the incidence rate and predictors of buprenorphine SR reactions in the subcutaneous tissue...

Year Published: 2021Topics: Drug/Substance AdministrationAnimal Type: Macaque, Nonhuman Primate

Citation: Haertel, A. J., Schultz, M. A., Colgin, L. M. et al. 2021. Predictors of subcutaneous injection site reactions to sustained-release buprenorphine in rhesus macaques (Macaca mulatta). JAALAS 60(3), 329-336.

Training pigs for oral glucose tolerance test—Six years’ experience of a refined model

Animal models of human diseases are important in biomedical research. When using animals for scientific purposes, the 3Rs (replace, reduce, refine) should be considered. Refinement of animal models is essential to ensure best use of animals, which is important for...

Year Published: 2021Topics: Animal Training, Drug/Substance AdministrationAnimal Type: Pig

Citation: Manell, E., Hedenqvist, P., Jensen-Waern, M. 2021. Training pigs for oral glucose tolerance test—Six years' experience of a refined model. Animals 11(6), 1677.

Report of the 2020 RSPCA/UFAW rodent and rabbit welfare meeting

The RSPCA/UFAW rodent and rabbit welfare group has held a one-day meeting every autumn for the last 27 years, so that its members can discuss current welfare research, exchange views on welfare issues and share experiences of the implementation of...

Year Published: 2021Topics: Drug/Substance Administration, Environmental Enrichment, Handling, Housing, Welfare AssessmentAnimal Type: Mouse, Rat, Rodent

Citation: Stevens, C., Hawkins, P., Smulders, T. V. et al. 2021. Report of the 2020 RSPCA/UFAW rodent and rabbit welfare meeting. Animal Technology and Welfare 20(1), 21-33.