Drug/Substance Administration

A method for reliable voluntary oral administration of a fixed dosage (mg/kg) of chronic daily medication to rats

Stress can influence a number of physiological processes including adult neurogenesis, metabolism, cardiovascular function, immune function, neurophysiological function, endocrine function and inflammatory processes following injury. In testing drugs which may be used to treat various diseases or injuries, reducing stress...

Year Published: 2012Topics: Drug/Substance AdministrationAnimal Type: Rat, Rodent

Citation: Corbett, A., McGowin, A., Sieber, S. et al. 2012. A method for reliable voluntary oral administration of a fixed dosage (mg/kg) of chronic daily medication to rats. Laboratory Animals 46(4), 318-324.

A safe, gentle and effective method of oral dosing guinea-pigs

Guinea pigs are difficult to oral gavage dose. Previous adverse effects from this dosing method, using rigid catheters, had caused an earlier endpoint to studies and loss of data. We therefore developed a prototype gag made from a 2.5 mL...

Year Published: 2012Topics: Drug/Substance AdministrationAnimal Type: Guinea Pig, Rodent

Citation: Blyth, L. 2012. A safe, gentle and effective method of oral dosing guinea-pigs. Animal Technology and Welfare 11, 187-188.

Voluntary ingestion of nut paste for administration of buprenorphine in rats and mice

An adequate analgesic strategy is important to improve the postoperative recovery and welfare of laboratory rats and mice. It is desirable that the method for administering the drug is non-invasive and stress-free. We have previously validated a method for administering...

Year Published: 2012Topics: Drug/Substance AdministrationAnimal Type: Mouse, Rat, Rodent

Citation: Abelson, K. S. P., Jacobsen, K. R., Sundbom, R. et al. 2012. Voluntary ingestion of nut paste for administration of buprenorphine in rats and mice. Laboratory Animals 46(4), 349-351.

Refinement of a macaque transplantation model: Application of a subcutaneous port as a means for long-term enteral drug administration and nutritional supplementation

A new application of a device enabling the long-term enteral administration of drugs or nutritional supplementation was developed for implementing in research entailing the use of macaques (Macaca fascicularis). After implanting a subcutaneous port, a surgically-placed gastrostomy (SPG) was completed...

Year Published: 2012Topics: Drug/Substance AdministrationAnimal Type: Macaque, Nonhuman Primate

Citation: Fante, F., Baldan, N., De Benedictis, G. M. et al. 2012. Refinement of a macaque transplantation model: Application of a subcutaneous port as a means for long-term enteral drug administration and nutritional supplementation. Laboratory Animals 46(2), 114-121.

Compassion Makes a Difference – Discussions by the Laboratory Animal Refinement & Enrichment Forum [LAREF], Volume III

This is the third volume of discussions that took place on the Laboratory Animal Refinement & Enrichment Forum (LAREF). This forum is dedicated to the exchange of personal experiences of refining the conditions under which animals are housed and handled...

Year Published: 2013Topics: Animal Training, Drug/Substance Administration, Environmental Enrichment, Housing, Social Housing & CompanionshipAnimal Type: Amphibian, Baboon, Cat, Chimpanzee, Dog, Fish, Frog & Toad, Goat, Macaque, Marmoset, Mouse, Nonhuman Primate, Owl Monkey, Pig, Rabbit, Rat, Reptile, Rodent, Sheep, Snake, Squirrel Monkey, Vervet (African Green Monkey), Zebrafish

Citation: Reinhardt, V. (ed.) 2013. Compassion Makes a Difference - Discussions by the Laboratory Animal Refinement & Enrichment Forum [LAREF], Volume III. Animal Welfare Institute, Washington, DC.