Disease/Experimental Model

Enriched environment causes epigenetic changes in hippocampus and improves long-term cognitive function in sepsis

Sepsis is defined as a life-threatening organ dysfunction caused by an inappropriate host response to infection. The presence of oxidative stress and inflammatory mediators in sepsis leads to dysregulated gene expression, leading to a hyperinflammatory response. Environmental conditions play an...

Year Published: 2022Topics: Disease/Experimental Model, Environmental EnrichmentAnimal Type: Rat, Rodent

Citation: Córneo, E., Michels, M., Abatti, M. et al. 2022. Enriched environment causes epigenetic changes in hippocampus and improves long-term cognitive function in sepsis. Scientific Reports 12(1), 11529.

Longitudinal home-cage automated assessment of climbing behavior shows sexual dimorphism and aging-related decrease in C57BL/6J healthy mice and allows early detection of motor impairment in the N171-82Q mouse model of Huntington’s disease

Monitoring the activity of mice within their home cage is proving to be a powerful tool for revealing subtle and early-onset phenotypes in mouse models. Video-tracking, in particular, lends itself to automated machine-learning technologies that have the potential to improve...

Year Published: 2023Topics: Behavioral & Cognitive Testing, Disease/Experimental Model, HandlingAnimal Type: Mouse, Rodent

Citation: Bains, R. S., Forrest, H., Sillito, R. R. et al. 2023. Longitudinal home-cage automated assessment of climbing behavior shows sexual dimorphism and aging-related decrease in C57BL/6J healthy mice and allows early detection of motor impairment in the N171-82Q mouse model of Huntington's disease. Frontiers in Behavioral Neuroscience 17, 1148172.

Animal welfare assessment after severe traumatic brain injury in rats

Severe traumatic brain injury (TBI) is a multifactorial injury process involving respiratory, cardiovascular and immune functions in addition to the brain. Thus, live animal models are needed to study the molecular, cellular and systemic mechanisms of TBI. The ethical use...

Year Published: 2022Topics: Disease/Experimental Model, Welfare AssessmentAnimal Type: Rat, Rodent

Citation: Allioux, C., Achaintre, L., Cheataini. F. et al. 2022. Animal welfare assessment after severe traumatic brain injury in rats. Laboratory Animals 56(6), 528-539.

Pivotal role of micro-CT technology in setting up an optimized lung fibrosis mouse model for drug screening

Idiopathic pulmonary fibrosis (IPF) is a progressive disease with no curative pharmacological treatment. The most used animal model of IPF for anti-fibrotic drug screening is bleomycin (BLM)-induced lung fibrosis. However, several issues have been reported: the balance among disease resolution,...

Year Published: 2022Topics: Disease/Experimental ModelAnimal Type: Mouse, Rodent

Citation: Khalajzeyqami, Z., Grandi, A., Ferrini, E. et al. 2022. Pivotal role of micro-CT technology in setting up an optimized lung fibrosis mouse model for drug screening. PLOS ONE 17(6), e0270005.

Refining the rat sciatic nerve block: A novel ultrasound-guided technique

Murine translational models are an important tool to understand pain pathophysiology. One procedure used frequently in murine research is the sciatic nerve block. This study sought to demonstrate the use of ultrasound-guided sciatic nerve block in a cadaveric murine model....

Year Published: 2022Topics: Disease/Experimental ModelAnimal Type: Rat, Rodent

Citation: Hughey, S., Campbell, D., Rapp-Santos, K. et al. 2022. Refining the rat sciatic nerve block: A novel ultrasound-guided technique. Laboratory Animals 56(2), 191-195.

Refinement of the stress-enhanced fear learning model of post-traumatic stress disorder: A behavioral and molecular analysis

Post-traumatic stress disorder (PTSD) is a debilitating mental health condition for which current treatments have long-term efficacy in 50% of patients. There is a clear need for better understanding of the mechanisms underlying PTSD and the development of new treatment...

Year Published: 2022Topics: Disease/Experimental ModelAnimal Type: Rat, Rodent

Citation: Van Assche, I. A., Padilla, M. S., Stupart, O. S. R. P. et al. 2022. Refinement of the stress-enhanced fear learning model of post-traumatic stress disorder: A behavioral and molecular analysis. Lab Animal 51(11), 293-300.

3R measures in facilities for the production of genetically modified rodents

Sociocultural changes in the human–animal relationship have led to increasing demands for animal welfare in biomedical research. The 3R concept is the basis for bringing this demand into practice: Replace animal experiments with alternatives where possible, Reduce the number of...

Year Published: 2022Topics: Analgesia, Disease/Experimental Model, Husbandry & Management, Reproduction, Surgery & Post-OpAnimal Type: Mouse, Rat, Rodent

Citation: Zevnik, B., Jerchow, B., Buch, T. 2022. 3R measures in facilities for the production of genetically modified rodents. Lab Animal 51(6), 162-177.

Improving well-being and survival in the 6-OHDA lesion model of Parkinson´s disease in mice: Literature review and step-by-step protocol

Parkinson's disease (PD) is the most common neurodegenerative motor disorder and primarily affects movement control but also a range of non-motor functions. With unknown etiology and lack of cure, much research is dedicated to unravel pathological mechanisms and improve clinical...

Year Published: 2022Topics: Disease/Experimental ModelAnimal Type: Mouse, Rodent

Citation: Guillaumin, A., Vlcek, B., Wallén-Mackenzie, Å. 2022. Improving well-being and survival in the 6-OHDA lesion model of Parkinson´s disease in mice: Literature review and step-by-step protocol. Scandinavian Journal of Animal Science 48(1), 1-21.

Effects of buprenorphine on model development in an adjuvant-induced monoarthritis rat model

Complete Freund's adjuvant (CFA)-induced arthritis in rats is a common animal model for studying chronic inflammatory pain. However, modelling of the disease is associated with unnecessary pain and impaired animal wellbeing, particularly in the immediate post-induction phase. Few attempts have...

Year Published: 2022Topics: Disease/Experimental ModelAnimal Type: Rat, Rodent

Citation: Berke, M. S., Fensholdt, L. K. D., Hestehave, S. et al. 2022. Effects of buprenorphine on model development in an adjuvant-induced monoarthritis rat model. PLOS ONE 17(1), e0260356.

Voluntary wheel running behaviour as a tool to assess the severity in a mouse pancreatic cancer model

Laboratory animals frequently undergo routine experimental procedures such as handling, restraining and injections. However, as a known source of stress, these procedures potentially impact study outcome and data quality. In the present study, we, therefore, performed an evidence-based severity assessment...

Year Published: 2021Topics: Disease/Experimental Model, Welfare AssessmentAnimal Type: Mouse, Rodent

Citation: Weegh, N., Zentrich, E., Zechner, D. et al. 2021. Voluntary wheel running behaviour as a tool to assess the severity in a mouse pancreatic cancer model. PLOS ONE 16(12), e0261662.