Disease/Experimental Model

TNFα depleting therapy improves fertility and animal welfare in TNFα-driven transgenic models of polyarthritis when administered in their routine breeding

Transgenic tumour necrosis factor alpha (TNFα)-driven models of polyarthritis such as the TNFΔARE mouse have proven to be invaluable in delineating aspects of inflammatory disease pathophysiology in humans. Unfortunately, the onset of joint destruction and inflammation in these models represents...

Year Published: 2018Topics: Disease/Experimental ModelAnimal Type: Mouse, Rodent

Citation: Naylor, A. J., Desanti, G., Saghir, A. N. et al. 2018. TNFα depleting therapy improves fertility and animal welfare in TNFα-driven transgenic models of polyarthritis when administered in their routine breeding. Laboratory Animals 52(1), 59-68.

A refined and translationally relevant model of chronic DSS colitis in BALB/c mice

Inflammatory bowel diseases (IBD) are chronic relapsing disorders of the gastrointestinal tract. Several mouse models for IBD are available, but the acute dextran sulfate sodium (DSS)-induced colitis model is mostly used for preclinical studies. However, this model lacks chronicity and...

Year Published: 2018Topics: Disease/Experimental ModelAnimal Type: Mouse, Rodent

Citation: Hoffmann, M., Schwertassek, U., Seydel, A. et al. 2018. A refined and translationally relevant model of chronic DSS colitis in BALB/c mice. Laboratory Animals 52(3), 240-252.

Ethical principles for the maintenance and use of animal in neuroscience research

Maintenance of experimental animals should account for species-specific needs of accommodation, activity, feeding and social interactions to the degree possible [p. 1].

Year Published: 1987Topics: Disease/Experimental ModelAnimal Type: All/General

Citation: Zimmermann, M. 1987. Ethical principles for the maintenance and use of animal in neuroscience research. Neuroscience Letters 73, 1.

Chimpanzees in AIDS research: A biomedical and bioethical perspective

The present article represents a consensus view of the appropriate utilization of chimpanzees in AIDS research arrived at as a result of a meeting of a group of scientists involved in AIDS research with chimpanzees and bioethicists. The paper considers...

Year Published: 1994Topics: Disease/Experimental Model, Relocation & Transport, Social Housing & CompanionshipAnimal Type: Chimpanzee, Nonhuman Primate

Citation: van Akker, R., Balls, M., Eichberg, J. W. et al. 1994. Chimpanzees in AIDS research: A biomedical and bioethical perspective. Journal of Medical Primatology 23, 49-51.

The Boyd Group of papers on: The use of non-human primates in research and testing – Pager 1: Background information on the use of non-human primates

Number of non-human primates used in scientific procedures in Britain in 2000: New World monkeys [marmosets, tamarins] 1060; Old World monkeys [macaques] 1891 [p.100].

Year Published: 2003Topics: Disease/Experimental ModelAnimal Type: Nonhuman Primate, Salamander

Citation: Smith, J. A., Boyd, K. M. e. 2003. The Boyd Group of papers on: The use of non-human primates in research and testing - Pager 1: Background information on the use of non-human primates. Animal Technology and Welfare 2, 99-103.

The poor contribution of chimpanzee experiments to biomedical progress

Biomedical research on captive chimpanzees incurs substantial nonhuman animal welfare, ethical, and financial costs that advocates claim result in substantial advancements in biomedical knowledge. However, demonstrating minimal contribution toward the advancement of biomedical knowledge generally, subsequent papers did not cite...

Year Published: 2007Topics: Disease/Experimental Model, Regulations & Ethical ReviewAnimal Type: Chimpanzee, Nonhuman Primate

Citation: Knight, A. 2007. The poor contribution of chimpanzee experiments to biomedical progress. Journal of Applied Animal Welfare Science 10(4), 281-308.

Report of the 2006 RSPCA/UFAW Rodent Welfare Group meeting

The RSPCA/UFAW Rodent Welfare Group holds a one-day meeting every autumn to discuss current welfare research and to exchange views on rodent welfare issues. A key aim of the group is to encourage people to think about the lifetime experience...

Year Published: 2008Topics: Disease/Experimental Model, Euthanasia, Housing, Husbandry & ManagementAnimal Type: Mouse, Rat, Rodent

Citation: Reed, B., Hawkins, P., Latham, N. et al. 2008. Report of the 2006 RSPCA/UFAW Rodent Welfare Group meeting. Lab Animal 37(5), 216-222.

Biomedical applications of sheep models: from asthma to vaccines

Although rodent models are very popular for scientific studies, it is becoming more evident that large animal models can provide unique opportunities for biomedical research. Sheep are docile in nature and large in size, which facilitates surgical manipulation, and their...

Year Published: 2008Topics: Disease/Experimental ModelAnimal Type: Sheep

Citation: Scheerlinck, J. P. Y., Snibson, K. J., Bowles, V. M. et al. 2008. Biomedical applications of sheep models: from asthma to vaccines. Trends in Biotechnology 26, 259-266.

Cage enrichment with paper tissue, but not plastic tunnels, increases variability in mouse model of asthma

Environmental enrichment, besides having a great impact on animal welfare, can also be a potential variable in experimental research. Thus, we investigated whether enrichment of cages with paper tissues or plastic tunnels affects scientific outcome in the well-described mouse model...

Year Published: 2011Topics: Disease/Experimental Model, Environmental Enrichment, HousingAnimal Type: Mouse, Rodent

Citation: Pasalic, I., Bosnjak, B., Ivetic Tkalcevic, V. et al. 2011. Cage enrichment with paper tissue, but not plastic tunnels, increases variability in mouse model of asthma. Laboratory Animals 45(2), 121-123.

The beneficial effects of enrichment on diabetic mice

In the last issue of The Enrichment Record, Emily Patterson-Kane and I reported on the work (Cao, Liu et al.) in which investigators demonstrated that even short-term exposure to environmental enrichment (EE) improved resistance to cancer in a number of...

Year Published: 2011Topics: Disease/Experimental Model, Environmental EnrichmentAnimal Type: Mouse, Rodent

Citation: Lett, G. S. 2011. The beneficial effects of enrichment on diabetic mice. Enrichment Record 6, 5.