Disease/Experimental Model

Fasting of male mice – Effects of time point of initiation and duration on clinical chemistry parameters and animal welfare

Fasting of mice is a common procedure, which can affect the outcome of the study as well as animal welfare. In this study, we assess the effects of fasting, fasting duration and fasting initiation time in relation to light schedule...

Year Published: 2019Topics: Disease/Experimental Model, Husbandry & ManagementAnimal Type: Mouse, Rodent

Citation: Jensen, T. L., Kiersgaard, M. K., Mikkelsen, L. F. et al. 2019. Fasting of male mice – Effects of time point of initiation and duration on clinical chemistry parameters and animal welfare. Laboratory Animals 53(6), 587–597.

Inventive enrichment to facilitate weight gain in the common marmoset (Callithrix jacchus) during invasive studies

To provide the highest standard of care to marmosets during invasive surgical studies, studies that often lead to weight loss, it is paramount to call upon inherent species-specific enrichment tactics to mitigate weight loss. Weight loss is common in marmosets...

Year Published: 2019Topics: Disease/Experimental Model, Environmental EnrichmentAnimal Type: Macaque, Nonhuman Primate

Citation: Heyworth, C. 2019. Inventive enrichment to facilitate weight gain in the common marmoset (Callithrix jacchus) during invasive studies. Laboratory Animal Science Professional 7(4) (December), 38-41.

Non-aversive photographic measurement method for subcutaneous tumours in nude mice

We have developed a new method for the measurement of subcutaneous tumour volume which consists in taking photographs of mice in their home cages, to refine the standard method of measurement with calipers. We consider this new method to be...

Year Published: 2019Topics: Disease/Experimental Model, Welfare AssessmentAnimal Type: Mouse, Rodent

Citation: Resasco, A., Carranza Martin, A. C., Ayala, M. A. et al. 2019. Non-aversive photographic measurement method for subcutaneous tumours in nude mice. Laboratory Animals 53(4), 352–361.

Evaluation of the effectiveness of preoperative administration of maropitant citrate and metoclopramide hydrochloride in preventing postoperative clinical gastroesophageal reflux in dogs

OBJECTIVE To investigate the prophylactic effectiveness of preoperative administration of maropitant citrate and metoclopramide hydrochloride in preventing postoperative clinical gastroesophageal reflux (GER) in dogs and to identify risk factors for clinical postoperative GER in dogs. ANIMALS 93 client-owned dogs undergoing...

Year Published: 2019Topics: Disease/Experimental ModelAnimal Type: Dog

Citation: Jones, C. T., Fransson, B. A. 2019. Evaluation of the effectiveness of preoperative administration of maropitant citrate and metoclopramide hydrochloride in preventing postoperative clinical gastroesophageal reflux in dogs. Journal of the American Veterinary Medical Association 255(4), 437-445.

Factors associated with dehiscence and mortality rates following gastrointestinal surgery in dogs

OBJECTIVE To identify factors associated with dehiscence and mortality rates following gastrointestinal surgery in dogs. ANIMALS 170 client-owned dogs that underwent gastrointestinal surgery from 2010 to 2016. PROCEDURES Medical records of all included dogs were reviewed to collect information on...

Year Published: 2019Topics: Disease/Experimental ModelAnimal Type: Dog

Citation: Gill, S. S., Buote, N. J., Peterson, N. W. et al. 2019. Factors associated with dehiscence and mortality rates following gastrointestinal surgery in dogs. Journal of the American Veterinary Medical Association 255(5), 569-573.

Human infant pants for postoperative protection during social housing of New Zealand white rabbits (Oryctolagus cuniculus)

Elizabethan collars (E-collars) are commonly used in various species to safeguard healing wounds. However, E-collars inadvertently restrict the expression of normal species-typical behaviors, including coprophagy, self-grooming, and social housing. To maintain social housing in accordance with recommendations in the 8th...

Year Published: 2019Topics: Disease/Experimental Model, Social Housing & CompanionshipAnimal Type: Rabbit

Citation: Bartley, K. A., Johnson, C. H. 2019. Human infant pants for postoperative protection during social housing of New Zealand white rabbits (Oryctolagus cuniculus). JAALAS 58(4), 510-516.

Identifying and implementing endpoints for geriatric mice

The types of changes in physical appearance and behavior that occur in elderly people similarly develop in elderly animals. Signs and symptoms that might cause concern in younger people or mice may be normal in their elderly but generally healthy...

Year Published: 2018Topics: Disease/Experimental Model, Humane EndpointAnimal Type: Mouse, Rodent

Citation: Toth, L. A. 2018. Identifying and implementing endpoints for geriatric mice. Comparative Medicine 68(6), 439–451.

Monitoring the health status of mice with bleomycin-induced lung injury by using body condition scoring

Well-defined, humane endpoints aid in monitoring animal health status during disease development. Body condition scoring (BCS) is a method for assessing health status in mouse studies where wasting and death are potential endpoints. Whether BCS is useful in monitoring animals...

Year Published: 2019Topics: Disease/Experimental Model, Humane EndpointAnimal Type: Mouse, Rodent

Citation: Cowley, P. M., Roberts, C. R., Baker, A. J. 2019. Monitoring the health status of mice with bleomycin-induced lung injury by using body condition scoring. Comparative Medicine 69(2), 95–102.

Comparison of isoflurane, ketamine-dexmedetomidine, and ketamine-xylazine for general anesthesia during oral procedures in rice rats (Oryzomys palustris)

Rice rats (Oryzomys palustris) are an unconventional laboratory species that has been used to study photoperiodicity, periodontitis, and osteonecrosis of the jaw. Interventional procedures that require anesthesia, including oral procedures, are sometimes necessary in preclinical settings. The use of anesthetics...

Year Published: 2019Topics: Anesthesia & Sedation, Disease/Experimental ModelAnimal Type: Rat, Rodent

Citation: Jiron, J. M., Mendieta Calle, J. L., Castillo, E. J. et al. 2019. Comparison of isoflurane, ketamine-dexmedetomidine, and ketamine-xylazine for general anesthesia during oral procedures in rice rats (Oryzomys palustris). JAALAS 58(1), 40-49.

Regional anesthesia for dentistry and orofacial surgery in rhesus macaques (Macaca mulatta)

Regional anesthesia is a commonly used adjunct to orofacial dental and surgical procedures in companion animals and humans. However, appropriate techniques for anesthetizing branches of the mandibular and maxillary nerves have not been described for rhesus monkeys. Skulls of 3...

Year Published: 2019Topics: Anesthesia & Sedation, Disease/Experimental ModelAnimal Type: Macaque, Nonhuman Primate

Citation: Engel, R. M., Thomas III, M. L., Banks, R. E. 2019. Regional anesthesia for dentistry and orofacial surgery in rhesus macaques (Macaca mulatta). JAALAS 58(2), 223-230.