Anesthesia & Sedation

Anesthetic effects of intramuscular alfaxalone–ketamine in naked mole rats (Heterocephalus glaber)

In this study, adult intact male and female (n = 10) naked mole rats (Heterocephalus glaber) were anesthetized by using a combination of ketamine (20 mg/kg IM), and alfaxalone (4.0 mg/kg IM). Induction and recovery times were recorded. Vital parameters,...

Year Published: 2020Topics: Anesthesia & SedationAnimal Type: Mole Rat, Rodent

Citation: Ambar, N., Eshar, D., Shrader, T. C. et al. 2020. Anesthetic effects of intramuscular alfaxalone–ketamine in naked mole rats (Heterocephalus glaber). JAALAS 59(5), 539-545.

A comparison of buffered tricaine methanesulfonate (MS-222) and isoeugenol anesthesia for caudal fin clipping in zebrafish (Danio rerio)

The purpose of this study was to compare the safety and efficacy of buffered tricaine methanesulfonate (MS-222) and isoeugenol for the anesthesia of zebrafish undergoing caudal fin clipping. Eighty 9 mo Danio rerio (AB strain) zebrafish were allocated to one...

Year Published: 2020Topics: Anesthesia & SedationAnimal Type: Fish, Zebrafish

Citation: Musk, G. C., Ezzy, B. J., Kenchington, L. M. et al. 2020. A comparison of buffered tricaine methanesulfonate (MS-222) and isoeugenol anesthesia for caudal fin clipping in zebrafish (Danio rerio). JAALAS 59(6), 732-736.

Hypothermia during general anesthesia interferes with pain assessment in laboratory rats (Rattus norvegicus)

Accurate pain assessment methods are necessary to ensure animal welfare and reliable data collection in animal research. The Rat Grimace Scale (RGS), a facial expression pain scale, allows effective identification of pain. However, the potential confounds of this method remain...

Year Published: 2020Topics: Anesthesia & Sedation, Surgery & Post-Op, Welfare AssessmentAnimal Type: Rat, Rodent

Citation: Klune, C. B., Robbins, H. N. K., Leung, V. et al. 2020. Hypothermia during general anesthesia interferes with pain assessment in laboratory rats (Rattus norvegicus). JAALAS 59(6), 719-725.

Development, validation, and reliability of a sedation scale in horses (EquiSed)

The lack of standardization of sedation scales in horses limits the reproducibility between different studies. This prospective, randomized, blinded, horizontal and controlled trial aimed to validate a scale for sedation in horses (EquiSed). Seven horses were treated with intravenous detomidine...

Year Published: 2021Topics: Anesthesia & SedationAnimal Type: Equine

Citation: Oliveira, A. R., Gozalo-Marcilla, M., Ringer, S. K. et al. 2021. Development, validation, and reliability of a sedation scale in horses (EquiSed). Frontiers in Veterinary Science 8, 611729.

Comparison of pre-emptive butorphanol or metamizole with ketamine +medetomidine and s-ketamine + medetomidine anaesthesia in improving intraoperative analgesia in mice

In accordance with the ‘refinement' component of the 3Rs, the primary aim of this study was to investigate and compare ketamine + medetomidine (KM) and s-ketamine + medetomidine (SKM) anaesthetic protocols in C57BL/6J mice (both sexes). We sought to determine whether s-ketamine could provide...

Year Published: 2019Topics: Analgesia, Anesthesia & SedationAnimal Type: Mouse, Rodent

Citation: Bauer, C., Schillinger, U., Brandl, J. et al. 2019. Comparison of pre-emptive butorphanol or metamizole with ketamine +medetomidine and s-ketamine + medetomidine anaesthesia in improving intraoperative analgesia in mice. Laboratory Animals 53(5), 459–469.

Multiple refinements to the anaesthetic protocol for laparoscopic orthotopic kidney auto-transplantation in a pig model

Fifty-four pigs (Sus scrofa, Large White cross) from a commercial pig farm were anaesthetised over a six-year period from October 2011. The procedural stages included initial instrumentation for intra-operative monitoring, laparoscopic nephrectomy, preparation of the kidney graft, orthotopic auto-transplantation by...

Year Published: 2019Topics: Analgesia, Anesthesia & Sedation, Cannulation, Catheterization, & Intubation, Surgery & Post-OpAnimal Type: Pig

Citation: Musk, G. C., Kershaw, H., He, B. 2019. Multiple refinements to the anaesthetic protocol for laparoscopic orthotopic kidney auto-transplantation in a pig model. Laboratory Animals 53(1), 72–78.

Anaesthetics and analgesics used in adult fish for research: A review

The number of fish used in research has increased in the last decades. Anaesthesia is required when fish must be held immobile and it is crucial to promote fish welfare, because these vertebrates can show signs of stress and/or pain...

Year Published: 2019Topics: Analgesia, Anesthesia & SedationAnimal Type: Fish, Shark & Ray

Citation: Martins, T., Valentim, A., Pereira, N. et al. 2019. Anaesthetics and analgesics used in adult fish for research: A review. Laboratory Animals 53(4), 325–341.

The effect of needle-free administration of local anesthetic on the behavior and physiology of castrated pigs

Pigs are routinely castrated in many countries without giving pain relief, which is an animal welfare concern. The objectives of this study were to evaluate the stress caused by administering local anesthetic (LA) using a needle-free injection system and evaluate...

Year Published: 2017Topics: Anesthesia & Sedation, Body Modification/MutilationAnimal Type: Pig

Citation: Sutherland, M. A., Backus, B. L., Brooks, T. A. 2017. The effect of needle-free administration of local anesthetic on the behavior and physiology of castrated pigs. Journal of Veterinary Behavior 21, 71-76.

Effect of injection site on dexmedetomidine-ketamine induced sedation in leopard geckos (Eublepharis macularius)

OBJECTIVE To evaluate whether the sedative effects of a combination of dexmedetomidine and ketamine differed when it was administered IM in a hind limb versus a forelimb of leopard geckos (Eublepharis macularius). DESIGN Randomized crossover study. ANIMALS 9 healthy adult...

Year Published: 2018Topics: Anesthesia & SedationAnimal Type: Lizard, Reptile

Citation: Fink, D. M., Doss, G. A., Sladky, K. K. et al. 2018. Effect of injection site on dexmedetomidine-ketamine induced sedation in leopard geckos (Eublepharis macularius). Journal of the American Veterinary Medical Association 253(9), 1146-1150.

Recovery characteristics of dogs following anesthesia induced with tiletamine-zolazepam, alfaxalone, ketamine-diazepam, or propofol and maintained with isoflurane

OBJECTIVE To compare characteristics of recovery from isoflurane anesthesia in healthy nonpremedicated dogs after anesthetic induction by IV administration of tiletamine-zolazepam with those observed after induction by IV administration of alfaxalone, ketamine-diazepam, or propofol. DESIGN Prospective, randomized crossover study. ANIMALS...

Year Published: 2019Topics: Anesthesia & SedationAnimal Type: Dog

Citation: Hampton, C. E., Riebold, T. W., Mandsager, R. E. 2019. Recovery characteristics of dogs following anesthesia induced with tiletamine-zolazepam, alfaxalone, ketamine-diazepam, or propofol and maintained with isoflurane. Journal of the American Veterinary Medical Association 254(12), 1421-1426.