Anesthesia & Sedation

Effects of rodent thermoregulation on animal models in the research environment

To best promote animal wellbeing and the efficacy of biomedical models, scientific, husbandry, and veterinary professionals must consider the mechanisms, influences, and outcomes of rodent thermoregulation in contemporary research environments. Over the last 2 decades, numerous studies have shown that...

Year Published: 2018Topics: Anesthesia & Sedation, Environmental EnrichmentAnimal Type: Mouse, Rat, Rodent

Citation: Hankenson, F. C., Marx, J. O., Gordon, C. J. et al. 2018. Effects of rodent thermoregulation on animal models in the research environment. Comparative Medicine 68(6), 425–438.

Report of the 2018 RSPCA/UFAW Rodent and Rabbit Welfare Group meeting

The RSPCA/UFAW Rodent (and now Rabbit) Working Group has held a one-day meeting every autumn for the last 25 years, so that its members can discuss current welfare research, exchange views on welfare issues and share experiences of the implementation...

Year Published: 2019Topics: Anesthesia & Sedation, Husbandry & ManagementAnimal Type: Mouse, Rodent

Citation: Stevens, C., Hawkins, P., Lovell-Badge, R. et al. 2019. Report of the 2018 RSPCA/UFAW Rodent and Rabbit Welfare Group meeting. Animal Technology and Welfare 18(2), 81-91.

Behavioural anxiety predisposes rabbits to intra-operative apnoea and cardiorespiratory instability

Rabbits are prone to complications from both anaesthesia and anxiety. Given that anxiety can often impact quality of anaesthesia, we developed a novel cage-side anxiety assessment, and sought to determine whether it correlated to pre- and intra-operative cardiorespiratory changes. We...

Year Published: 2019Topics: Anesthesia & SedationAnimal Type: Rabbit

Citation: Krall, C., Glass, S., Dancourt, G. et al. 2019. Behavioural anxiety predisposes rabbits to intra-operative apnoea and cardiorespiratory instability. Applied Animal Behaviour Science 221, 104875.

Anaesthetic and perioperative management of 14 male New Zealand white rabbits for calvarial bone surgery

Calvarial bone surgery on rabbits is frequently performed. This report aims to document a simple and practical anaesthetic and perioperative management for this procedure. Fourteen male New Zealand white rabbits were included in the study. Subcutaneous (SC) dexmedetomidine, ketamine and...

Year Published: 2019Topics: Analgesia, Anesthesia & Sedation, Disease/Experimental ModelAnimal Type: Rabbit

Citation: Raillard, M., Detotto, C., Grepper, S. et al. 2019. Anaesthetic and perioperative management of 14 male New Zealand white rabbits for calvarial bone surgery. Animals 9(11), 896.

Do fish perceive anaesthetics as aversive?

This study addresses a fundamental question in fish welfare: are the anaesthetics used for fish aversive? Despite years of routine general use of many agents, within both scientific research and aquaculture, there is a paucity of information regarding their tolerance...

Year Published: 2013Topics: Anesthesia & SedationAnimal Type: Fish, Zebrafish

Citation: Readman, G. D., Owen, S. F., Murrell, J. C. et al. 2013 Do fish perceive anaesthetics as aversive? PLOS ONE. 8(9), e73773.

Physiological and behavioural evaluation of common anaesthesia practices in the rainbow trout

Anaesthetic drugs are commonly administered to fish in aquaculture, research and veterinary contexts. Anaesthesia causes temporary absence of consciousness and may reduce the stress and/or pain associated with handling and certain invasive procedures. The rainbow trout (Oncorhynchus mykiss) is a...

Year Published: 2018Topics: Anesthesia & SedationAnimal Type: Fish, Trout

Citation: Pounder, K. C., Mitchell, J. L., Thomson, J. S. et al. 2018. Physiological and behavioural evaluation of common anaesthesia practices in the rainbow trout. Applied Animal Behaviour Science 199, 94-102.

Recovery of horses from general anesthesia after induction with propofol and ketamine versus midazolam and ketamine

OBJECTIVE To evaluate quality of recovery from general anesthesia in horses after induction with propofol and ketamine versus midazolam and ketamine. DESIGN Prospective randomized crossover study. ANIMALS 6 healthy adult horses. PROCEDURES Horses were premedicated with xylazine (1.0 mg/kg [0.45...

Year Published: 2018Topics: Anesthesia & SedationAnimal Type: Equine

Citation: Jarrett, M. A., Bailey, K. M., Messenger, K. M. et al. 2018. Recovery of horses from general anesthesia after induction with propofol and ketamine versus midazolam and ketamine. Journal of the American Veterinary Medical Association 253(1), 101-107.

Effects of alfaxalone administered intravenously to healthy yearling loggerhead sea turtles (Caretta caretta) at three different doses

OBJECTIVE To compare physiologic and anesthetic effects of alfaxalone administered IV to yearling loggerhead sea turtles (Caretta caretta) at 3 different doses. DESIGN Randomized crossover study. ANIMALS 9 healthy yearling loggerhead sea turtles. PROCEDURES Animals received each of 3 doses...

Year Published: 2017Topics: Anesthesia & SedationAnimal Type: Reptile, Turtle & Tortoise

Citation: Phillips, B. E., Posner, L. P., Lewbart, G. A. et al. 2017. Effects of alfaxalone administered intravenously to healthy yearling loggerhead sea turtles (Caretta caretta) at three different doses. Journal of the American Veterinary Medical Association 250(8), 909-917.

Intramuscular infiltration of a local anesthetic, lidocaine, does not result in adverse behavioural side effects in rainbow trout

Fish are a useful animal model for research, but our improvement in some aspects of their welfare has not kept pace with their increased popularity for this use. For example, researchers rarely use analgesics. We evaluated the side effects of...

Year Published: 2018Topics: Anesthesia & SedationAnimal Type: Fish, Trout

Citation: Chatigny, F., Creighton, C. M., Stevens, E. D. 2018. Intramuscular infiltration of a local anesthetic, lidocaine, does not result in adverse behavioural side effects in rainbow trout. Scientific Reports 8, 10250.

Comparison of atipamezole with yohimbine for antagonism of xylazine in mice anesthetized with ketamine and xylazine

The α2 adrenergic agonist xylazine produces a sedative effect and is typically combined with ketamine and used for anesthesia or chemical restraint of laboratory mice. Xylazine's sedative effect—and its undesirable side effects of bradycardia, hypotension, and poor tissue perfusion—can be...

Year Published: 2017Topics: Anesthesia & SedationAnimal Type: Mouse, Rodent

Citation: Janssen, C. F., Maiello, P., Wright Jr, M. J. et al. 2017. Comparison of atipamezole with yohimbine for antagonism of xylazine in mice anesthetized with ketamine and xylazine. JAALAS 56(2), 142-147.