Anesthesia & Sedation

Effect of injection site on dexmedetomidine-ketamine induced sedation in leopard geckos (Eublepharis macularius)

OBJECTIVE To evaluate whether the sedative effects of a combination of dexmedetomidine and ketamine differed when it was administered IM in a hind limb versus a forelimb of leopard geckos (Eublepharis macularius). DESIGN Randomized crossover study. ANIMALS 9 healthy adult...

Year Published: 2018Topics: Anesthesia & SedationAnimal Type: Lizard, Reptile

Citation: Fink, D. M., Doss, G. A., Sladky, K. K. et al. 2018. Effect of injection site on dexmedetomidine-ketamine induced sedation in leopard geckos (Eublepharis macularius). Journal of the American Veterinary Medical Association 253(9), 1146-1150.

Recovery characteristics of dogs following anesthesia induced with tiletamine-zolazepam, alfaxalone, ketamine-diazepam, or propofol and maintained with isoflurane

OBJECTIVE To compare characteristics of recovery from isoflurane anesthesia in healthy nonpremedicated dogs after anesthetic induction by IV administration of tiletamine-zolazepam with those observed after induction by IV administration of alfaxalone, ketamine-diazepam, or propofol. DESIGN Prospective, randomized crossover study. ANIMALS...

Year Published: 2019Topics: Anesthesia & SedationAnimal Type: Dog

Citation: Hampton, C. E., Riebold, T. W., Mandsager, R. E. 2019. Recovery characteristics of dogs following anesthesia induced with tiletamine-zolazepam, alfaxalone, ketamine-diazepam, or propofol and maintained with isoflurane. Journal of the American Veterinary Medical Association 254(12), 1421-1426.

International survey on the use and welfare of zebrafish Danio rerio in research

A survey was conducted regarding zebrafish Danio rerio use for scientific research with a focus on: anaesthesia and euthanasia; housing and husbandry; breeding and production; refinement opportunities. A total of 98 survey responses were received from laboratories in 22 countries...

Year Published: 2017Topics: Anesthesia & Sedation, Environmental Enrichment, Euthanasia, Housing, Husbandry & Management, Identification Method, ReproductionAnimal Type: Fish, Zebrafish

Citation: Lidster, K., Readman, G. D., Prescott, M. J. et al. 2017. International survey on the use and welfare of zebrafish Danio rerio in research. Journal of Fish Biology 90(5), 1891-1905.

Ethical considerations in fish research

In this review, we focus primarily on the refinement of common methods used in fish research based on emerging knowledge with the aim of improving the welfare of fish used in scientific studies. We consider the use of anaesthetics and...

Year Published: 2019Topics: Analgesia, Anesthesia & Sedation, Husbandry & ManagementAnimal Type: Fish, Other Fish, Salmon, Tilapia, Trout, Zebrafish

Citation: Sloman, K, A., Bouyoucos, I. A., Brooks, E. J. et al. 2019. Ethical considerations in fish research. Journal of Fish Biology 94(4), 556-577.

Cephalopod biology and care, a COST FA1301 (CephsInAction) training school: Anaesthesia and scientific procedures

Cephalopods are the sole invertebrates included in the list of regulated species following the Directive 2010/63/EU. According to the Directive, achieving competence through adequate training is a requisite for people having a role in the different functions (article 23) as...

Year Published: 2017Topics: Anesthesia & Sedation, Euthanasia, Natural Behavior, Relocation & TransportAnimal Type: Cephalopod, Invertebrate

Citation: Lopes, V. M., Sampaio, E., Roumbedakis, K. et al. 2017. Cephalopod biology and care, a COST FA1301 (CephsInAction) training school: Anaesthesia and scientific procedures. Invertebrate Neuroscience 17, 8.

Evaluation of tissue changes following intramuscular infiltration of lidocaine in rainbow trout Oncorhynchus mykiss

Rainbow trout Oncorhynchus mykiss were infiltrated with either saline or lidocaine adjacent to the dorsal fin to assess histopathological changes. Infiltration was done as if it were being used as a local anaesthetic. Tissue lesions and associated tissue healing were...

Year Published: 2018Topics: Anesthesia & Sedation, Drug/Substance AdministrationAnimal Type: Fish, Trout

Citation: Chatigny, F., Groman, D. B., Martinson, S. A. et al. 2018. Evaluation of tissue changes following intramuscular infiltration of lidocaine in rainbow trout Oncorhynchus mykiss. Journal of Fish Biology 92(4), 888-900.

Effects of repeated anaesthesia on gill and general health of Atlantic salmon, Salmo salar

Fish are the second most widely utilized vertebrate group used for scientific procedures in the United Kingdom, but the development and application of 3Rs (the principles of replacement, reduction, and refinement) in aquaculture disease research lags behind methodologies in place...

Year Published: 2018Topics: Anesthesia & SedationAnimal Type: Fish, Salmon

Citation: Chance, R. J., Cameron, G. A., Fordyce, M. et al. 2018. Effects of repeated anaesthesia on gill and general health of Atlantic salmon, Salmo salar. Journal of Fish Biology 93(6), 1069-1081.

Alfaxalone-xylazine anesthesia in laboratory mice (Mus musculus)

Since its recent reformulation, alfaxalone has gained popularity as an injectable veterinary anesthetic, including promising studies demonstrating the use of alfaxalone-xylazine for anesthesia in mice. Here we sought to expand these studies by testing additional dose ranges, elaborating on physiologic...

Year Published: 2019Topics: Anesthesia & SedationAnimal Type: Mouse, Rodent

Citation: Erickson, R. L., Blevins, C. E., De Souza Dyer, C. et al. 2019. Alfaxalone-xylazine anesthesia in laboratory mice (Mus musculus). JAALAS 58(1), 30-39.

Comparison of isoflurane, ketamine-dexmedetomidine, and ketamine-xylazine for general anesthesia during oral procedures in rice rats (Oryzomys palustris)

Rice rats (Oryzomys palustris) are an unconventional laboratory species that has been used to study photoperiodicity, periodontitis, and osteonecrosis of the jaw. Interventional procedures that require anesthesia, including oral procedures, are sometimes necessary in preclinical settings. The use of anesthetics...

Year Published: 2019Topics: Anesthesia & Sedation, Disease/Experimental ModelAnimal Type: Rat, Rodent

Citation: Jiron, J. M., Mendieta Calle, J. L., Castillo, E. J. et al. 2019. Comparison of isoflurane, ketamine-dexmedetomidine, and ketamine-xylazine for general anesthesia during oral procedures in rice rats (Oryzomys palustris). JAALAS 58(1), 40-49.

Comparison of dexmedetomidine-ketamine-midazolam and isoflurane for anesthesia of black-tailed prairie dogs (Cynomys ludovicianus)

Few studies evaluate anesthesia in black-tailed prairie dogs (Cynomys ludovicianus). Isoflurane inhalant anesthesia is used in this species most commonly, but injectable protocols are poorly described. Here we compared the physiologic effects, including anesthetic depth, vital signs, and hematologic changes,...

Year Published: 2019Topics: Anesthesia & SedationAnimal Type: Other Rodent, Rodent

Citation: Browning, G. R., Eshar, D., Beaufrere, H. 2019. Comparison of dexmedetomidine-ketamine-midazolam and isoflurane for anesthesia of black-tailed prairie dogs (Cynomys ludovicianus). JAALAS 58(1), 50-57.