Analgesia

Is it time for insect researchers to consider their subjects’ welfare?

Recent evidence suggests that at least some insect species might plausibly feel pain. These findings should prompt researchers to think about the welfare implications of insect experiments.

Year Published: 2023Topics: Analgesia, Emotion, Pain, & SentienceAnimal Type: Insect & Spider, Invertebrate

Citation: Crump, A., Gibbons, M., Barrett, M. et al. 2023. Is it time for insect researchers to consider their subjects' welfare? PLOS Biology 21(6), e3002138.

3R measures in facilities for the production of genetically modified rodents

Sociocultural changes in the human–animal relationship have led to increasing demands for animal welfare in biomedical research. The 3R concept is the basis for bringing this demand into practice: Replace animal experiments with alternatives where possible, Reduce the number of...

Year Published: 2022Topics: Analgesia, Disease/Experimental Model, Husbandry & Management, Reproduction, Surgery & Post-OpAnimal Type: Mouse, Rat, Rodent

Citation: Zevnik, B., Jerchow, B., Buch, T. 2022. 3R measures in facilities for the production of genetically modified rodents. Lab Animal 51(6), 162-177.

Assessment of the safety and efficacy of pre-emptive use of extended-release buprenorphine for mouse laparotomy

Buprenorphine is commonly used to control postoperative pain in rodents. Short-acting formulations of buprenorphine (bup-HCl) require frequent handling and restraint of animals for appropriate dosing, which can be stressful and confound research outcomes. Ethiqa XR (bup-ER) is an FDA-indexed extended-release...

Year Published: 2022Topics: AnalgesiaAnimal Type: Mouse, Rodent

Citation: Chan, G., Si, C., Nichols, M. R. et al. 2022. Assessment of the safety and efficacy of pre-emptive use of extended-release buprenorphine for mouse laparotomy. JAALAS 61(4), 381-387.

Efficacy of lidocaine topical solution in reducing discomfort reaction of horses to intramuscular vaccination

Vaccinations via intramuscular injection are a key component of preventative health care in horses. Development of problematic behavioral aversion to injections is quite common. Our clinical impression has been that topical anesthetic applied to injection sites can reduce the behavioral...

Year Published: 2022Topics: Analgesia, Drug/Substance AdministrationAnimal Type: Equine

Citation: Torcivia, C., McDonnell, S. 2022. Efficacy of lidocaine topical solution in reducing discomfort reaction of horses to intramuscular vaccination. Animals 12(13), 1659.

Challenges with assessing and treating pain in research primates: A focused survey and literature review

Research primates may undergo surgical procedures making effective pain management essential to ensure good animal welfare and unbiased scientific data. Adequate pain mitigation is dependent on whether veterinarians, technicians, researchers, and caregivers can recognize and assess pain, as well as...

Year Published: 2022Topics: Analgesia, Welfare AssessmentAnimal Type: Baboon, Chimpanzee, Macaque, Nonhuman Primate, Other Nonhuman Primate, Owl Monkey, Squirrel Monkey, Vervet (African Green Monkey)

Citation: Paterson, E. A., Turner, P. V. 2022. Challenges with assessing and treating pain in research primates: A focused survey and literature review. Animals 12(17), 2304.

Role of topical anaesthesia in pain management of farm animals, a changing paradigm

Field evidence indicates that livestock producers are motivated by access to products that readily deliver pain management during husbandry interventions and, more recently, viral epidermal infectious diseases, including FMD. There has been impressive adoption in Australia of a farmer-applied spray-on...

Year Published: 2022Topics: AnalgesiaAnimal Type: Cattle, Goat, Pig, Sheep

Citation: Windsor, P. A. 2022. Role of topical anaesthesia in pain management of farm animals, a changing paradigm. Animals 12(18), 2459.

Evaluating pain and analgesia effectiveness following routine castration in rabbits using behavior and facial expressions

Prevention of pain in rabbits is a priority for both welfare and validity of scientific data. We aimed to determine if the rabbit grimace scale (RbtGS) could be used as a viable, rapid assessment tool in two breeds of rabbit,...

Year Published: 2022Topics: AnalgesiaAnimal Type: Rabbit

Citation: Miller, A. L., Clarkson, J. M., Quigley, C. et al. 2022. Evaluating pain and analgesia effectiveness following routine castration in rabbits using behavior and facial expressions. Frontiers in Veterinary Science 9, 782486.

Pain and pain management in sea turtle and herpetological medicine: State of the art

In sea turtle rescue and rehabilitative medicine, many of the casualties suffer from occurrences that would be considered painful in other species; therefore, the use of analgesic drugs should be ethically mandatory to manage the pain and avoid its deleterious...

Year Published: 2022Topics: AnalgesiaAnimal Type: Reptile, Turtle & Tortoise

Citation: Serinelli, I., Soloperto, S., Lai, O. R. 2022. Pain and pain management in sea turtle and herpetological medicine: State of the art. Animals 12(6), 697.

Effects of multimodal analgesic protocol, with buprenorphine and meloxicam, on mice well-being: A dose finding study

The anesthetic or analgesic agent of choice, route and frequency of anesthetic or analgesic administration, and stressors induce distress during the perioperative period. We evaluated a multimodal analgesic protocol using buprenorphine and meloxicam on the well-being of mice. Twenty-four Slc:ICR...

Year Published: 2021Topics: AnalgesiaAnimal Type: Mouse, Rodent

Citation: Furumoto, K., Ogita, K., Kamisaka, T. et al. 2021. Effects of multimodal analgesic protocol, with buprenorphine and meloxicam, on mice well-being: A dose finding study. Animals 11(12), 3420.

Three studies evaluating the potential for lidocaine, bupivacaine or procaine to reduce pain-related behaviors following ring castration and/or tail docking in lambs

The use of local anesthesia at the time of ring castration and tail docking can improve lamb welfare. However, few local anesthetics are registered for sheep, and data on their duration of effect is limited. Three studies were conducted to...

Year Published: 2021Topics: Analgesia, Body Modification/MutilationAnimal Type: Sheep

Citation: Small, A., Fetiveau, M., Smith, R. et al. 2021. Three studies evaluating the potential for lidocaine, bupivacaine or procaine to reduce pain-related behaviors following ring castration and/or tail docking in lambs. Animals 11(12), 3583.