Analgesia

Analgesia in clinically relevant rodent models of sepsis

Postoperative analgesia in rodent sepsis models has been considerably neglected in the past. However, intentions to model clinical practice, increasing awareness of animal ethics, efforts to apply the 3Rs (replacement, reduction, refinement), and stricter legislation argue for a change in...

Year Published: 2016Topics: AnalgesiaAnimal Type: Mouse, Rodent

Citation: Jeger, V., Hauffe, T., Nicholls-Vuille, F. et al. 2016. Analgesia in clinically relevant rodent models of sepsis. Laboratory Animals 50(6), 418-426.

Anaesthesia and analgesia in laboratory adult zebrafish: a question of refinement

Anaesthesia is used daily in fish experimental procedures; however, the use of an inadequate anaesthetic protocol can compromise not only the animal's welfare but also the reliability of results. The use of zebrafish (Danio rerio) in biomedical research has increased...

Year Published: 2016Topics: Analgesia, Anesthesia & SedationAnimal Type: Fish, Zebrafish

Citation: Martins, T., Valentim, A. M., Pereira, L. N. et al. 2016. Anaesthesia and analgesia in laboratory adult zebrafish: a question of refinement. Laboratory Animals 50(6), 476-488.

Minimally invasive technique for intrathecal administration of morphine in rats: Practicality and antinociceptive properties

The intrathecal (IT) route of administration represents a means to reduce the dose of morphine administered for analgesia, potentially minimizing interactions between opioid effects and experimental outcomes. Perceived technical difficulty, and previously described invasive methods, may limit its use. This...

Year Published: 2017Topics: AnalgesiaAnimal Type: Rat, Rodent

Citation: Thomas, A. A., Detilleux, J., Sandersen, C. F. et al. 2017. Minimally invasive technique for intrathecal administration of morphine in rats: Practicality and antinociceptive properties. Laboratory Animals 51(5), 479-489.

Antinociceptive effects of voluntarily ingested buprenorphine in the hot-plate test in laboratory rats

Researchers performing experiments on animals should always strive towards the refinement of experiments, minimization of stress and provision of better animal welfare. An adequate analgesic strategy is important to improve post-operative recovery and welfare in laboratory rats and mice. In...

Year Published: 2017Topics: AnalgesiaAnimal Type: Rat, Rodent

Citation: Hestehave, S., Munro, G., Brønnum Pedersen, T. et al. 2017. Antinociceptive effects of voluntarily ingested buprenorphine in the hot-plate test in laboratory rats. Laboratory Animals 51(3), 264-272.

Analgesics promote welfare and sustain tumour growth in orthotopic 4T1 and B16 mouse cancer models

Murine orthotopic cancer models often require surgery, potentially causing pain or distress. However, analgesics are often withheld because they may alter tumour development. Two orthotopically implanted cancers were investigated in mice pre-treated with meloxicam (10 mg/kg), buprenorphine (0.2 mg/kg) or...

Year Published: 2018Topics: AnalgesiaAnimal Type: Mouse, Rodent

Citation: Lofgren, J., Miller, A. L., Shan Lee, C. C. et al. 2018. Analgesics promote welfare and sustain tumour growth in orthotopic 4T1 and B16 mouse cancer models. Laboratory Animals 52(4), 351-364.

Effects of carprofen, meloxicam and butorphanol on broiler chickens’ performance in mobility tests

Lame broiler chickens perform poorly in standardised mobility tests and have nociceptive thresholds that differ from those of non-lame birds, even when confounding factors such as differences in bodyweight are accounted for. This study investigated whether these altered responses could...

Year Published: 2016Topics: AnalgesiaAnimal Type: Bird, Chicken

Citation: Hothersall, B., Caplen, G., Parker, R. M. A. et al. 2016. Effects of carprofen, meloxicam and butorphanol on broiler chickens' performance in mobility tests. Animal Welfare 25(1), 55-67.

Reduction in activity by noxious chemical stimulation is ameliorated by immersion in analgesic drugs in zebrafish

Research has recently demonstrated that larval zebrafish show similar molecular responses to nociception to those of adults. Our study explored whether unprotected larval zebrafish exhibited altered behaviour after exposure to noxious chemicals and screened a range of analgesic drugs to...

Year Published: 2017Topics: Analgesia, Welfare AssessmentAnimal Type: Fish, Zebrafish

Citation: Lopez-Luna, J., Al-Jubouri, Q., Al-Nuaimy, W. et al. 2017. Reduction in activity by noxious chemical stimulation is ameliorated by immersion in analgesic drugs in zebrafish. Journal of Experimental Biology 220(8), 1451-1458.

Is there a reasonable excuse for not providing post-operative analgesia when using animal models of peripheral neuropathic pain for research purposes?

Introduction: The induction of neuropathic pain-like behaviors in rodents often requires surgical intervention. This engages acute nociceptive signaling events that contribute to pain and stress post-operatively that from a welfare perspective demands peri-operative analgesic treatment. However, a large number of...

Year Published: 2017Topics: AnalgesiaAnimal Type: Rat, Rodent

Citation: Hestehave, S., Munro, G., Christensen, R. et al. 2017. Is there a reasonable excuse for not providing post-operative analgesia when using animal models of peripheral neuropathic pain for research purposes? PLOS ONE 12(11), e0188113.

Evaluating treatments with topical anaesthetic and buccal meloxicam for pain and inflammation caused by amputation dehorning of calves

To assess the effects of a topical anaesthetic (TA) and buccal meloxicam (BM) on behaviour, maximum wound temperature and wound morphology following amputation dehorning of beef calves, 50 unweaned Hereford calves were randomly allocated to: (1) sham dehorning / control...

Year Published: 2018Topics: Analgesia, Body Modification/MutilationAnimal Type: Cattle

Citation: Van der Saag, D., Lomax, S., Windsor, P. A. et al. 2018. Evaluating treatments with topical anaesthetic and buccal meloxicam for pain and inflammation caused by amputation dehorning of calves. PLOS ONE 13(6), e0198808.

Impact of inhalation anaesthesia, surgery and analgesic treatment on home cage behaviour in laboratory mice

Anaesthesia and analgesia are used frequently in laboratory routine to ensure animal welfare and good scientific outcomes in experiments that may elicit pain or require immobilisation of the animal. However, there is concern regarding the effect of these procedures on...

Year Published: 2014Topics: Analgesia, Anesthesia & Sedation, Surgery & Post-OpAnimal Type: Mouse, Rodent

Citation: Cesarovic, N., Arras, M., Jirkof, P. 2014. Impact of inhalation anaesthesia, surgery and analgesic treatment on home cage behaviour in laboratory mice. Applied Animal Behaviour Science. 157, 137-145.