Analgesia

Evaluation of pain assessment techniques and analgesia efficacy in a female guinea pig (Cavia porcellus) model of surgical pain

Guinea pigs (Cavia porcellus) are a frequently used species in research, often involving potentially painful procedures. Therefore, evidence-based recommendations regarding analgesia are critically needed to optimize their wellbeing. Our laboratory examined the efficacy of carprofen and extended-release (ER) buprenorphine, alone...

Year Published: 2017Topics: Analgesia, Welfare AssessmentAnimal Type: Guinea Pig, Rodent

Citation: Oliver, V. L., Athavale, S., Simon, K. E. et al. 2017. Evaluation of pain assessment techniques and analgesia efficacy in a female guinea pig (Cavia porcellus) model of surgical pain. JAALAS 56(4), 425-435.

Pharmacokinetics of a novel, transdermal fentanyl solution in rhesus macaques (Macaca mulatta)

Rhesus macaques (Macaca mulatta) are the most commonly used NHP biomedical model and experience both research and clinical procedures requiring analgesia. Opioids are a mainstay of analgesic therapy. A novel, transdermal fentanyl solution (TFS) has been developed as a long-acting,...

Year Published: 2017Topics: AnalgesiaAnimal Type: Macaque, Nonhuman Primate

Citation: Salyards, G. W., Lemoy, M.-J., Knych, H. K. et al. 2017. Pharmacokinetics of a novel, transdermal fentanyl solution in rhesus macaques (Macaca mulatta). JAALAS 56(4), 443-451.

Uses and doses of local anesthetics in fish, amphibians, and reptiles

Local anesthetics are an integral part of routine pain management in mammals, yet their use is relatively limited in fish, amphibians and reptiles. These animals frequently undergo potentially painful surgical procedures and therefore could possibly benefit from those drugs. Some...

Year Published: 2017Topics: Analgesia, Anesthesia & SedationAnimal Type: Amphibian, Crocodile & Alligator, Fish, Frog & Toad, Lizard, Other Fish, Reptile, Salamander, Salmon, Snake, Tilapia, Trout, Turtle & Tortoise, Zebrafish

Citation: Chatigny, F., Kamunde, C., Creighton, C. M. et al. 2017. Uses and doses of local anesthetics in fish, amphibians, and reptiles. JAALAS 56(3), 244-253.

Updated review of fish analgesia

Analgesics are an integral part of routine pain management in mammals, yet their use in fish is still limited. Some recommendations on the use of analgesics in fish are currently in the literature; however, information on the properties of analgesic...

Year Published: 2018Topics: AnalgesiaAnimal Type: Fish, Other Fish, Salmon, Tilapia, Trout, Zebrafish

Citation: Chatigny, F., Creighton, C. M., Stevens, E. D. 2018. Updated review of fish analgesia. JAALAS 57(1), 5-12.

Pharmacokinetics and adverse effects of 3 sustained-release buprenorphine dosages in healthy guinea pigs (Cavia porcellus)

In guinea pigs, studies addressing the efficacy, safety, and pharmacokinetic profiles of different sustained-release buprenorphine (SRB) formulations are still in their infancy. Here we assessed the pharmacokinetic profiles of 3 SRB dosages (SR-LAB, ZooPharm; SRBLow, 0.15 mg/kg; SRBMedium, 0.3 mg/kg;...

Year Published: 2017Topics: AnalgesiaAnimal Type: Guinea Pig, Rodent

Citation: Zanetti, A. S., Putta, S. K., Casebolt, D. B. et al. 2017. Pharmacokinetics and adverse effects of 3 sustained-release buprenorphine dosages in healthy guinea pigs (Cavia porcellus). JAALAS 56(6), 768-778.

Analgesic efficacy and safety of buprenorphine in chinchillas (Chinchilla lanigera)

Buprenorphine is routinely used in chinchillas at reported doses of 0.01 to 0.1 mg/kg IM or SC. However, these dose recommendations are based on anecdotal reports or extrapolation from studies in other species. Therefore, the purpose of this study was...

Year Published: 2018Topics: AnalgesiaAnimal Type: Chinchilla, Rodent

Citation: Fox, L., Mans, C. 2018. Analgesic efficacy and safety of buprenorphine in chinchillas (Chinchilla lanigera). JAALAS 57(3), 286-290.

Analgesic efficacy and safety of hydromorphone in chinchillas (Chinchilla lanigera)

Limited information is available regarding the efficacy of opioid analgesics in chinchillas. Here we sought to evaluate the analgesic efficacy and safety of hydromorphone in chinchillas. In a randomized, controlled, blind, complete crossover design, hydromorphone was administered at 0.5, 1,...

Year Published: 2018Topics: AnalgesiaAnimal Type: Chinchilla, Rodent

Citation: Evenson, E. A., Mans, C. 2018. Analgesic efficacy and safety of hydromorphone in chinchillas (Chinchilla lanigera). JAALAS 57(3), 282-285.

Comparison of etomidate, benzocaine, and MS222 anesthesia with and without subsequent flunixin meglumine analgesia in African clawed frogs (Xenopus laevis)

Often few alternative anesthetics for exotic species are available, due to the small numbers of these animals used in research. In this study, we evaluated the depth and duration of anesthesia in Xenopus laevis after their immersion in 3 doses...

Year Published: 2018Topics: Analgesia, Anesthesia & SedationAnimal Type: Amphibian, Frog & Toad

Citation: Smith, B. D., Vail, K. J., Carroll, G. L. et al. 2018. Comparison of etomidate, benzocaine, and MS222 anesthesia with and without subsequent flunixin meglumine analgesia in African clawed frogs (Xenopus laevis). JAALAS 57(2), 202-209.

Analgesic efficacy of subcutaneous–oral dosage of tramadol after surgery in C57BL/6J mice

This study investigated the analgesic activity of tramadol in female C57BL/6J mice by using a single subcutaneous injection (25 mg/kg) of tramadol combined with the same dose given in drinking water for 24 h. We then evaluated the pharmacokinetics of...

Year Published: 2018Topics: AnalgesiaAnimal Type: Mouse, Rodent

Citation: Evangelista-Vaz, R., Bergadano, A., Arras, M. et al. 2018. Analgesic efficacy of subcutaneous–oral dosage of tramadol after surgery in C57BL/6J mice. JAALAS 57(4), 368-375.

Analgesic efficacy and hematologic effects of robenacoxib in mice

NSAID analgesics may confound models that require inflammation to mimic disease development in humans. This effect presents a challenge for veterinary staff and investigators, because surgery is often necessary to create mouse models of disease and NSAID are first-line analgesics...

Year Published: 2018Topics: AnalgesiaAnimal Type: Mouse, Rodent

Citation: Beninson, J. A., Lofgren, J. L., Lester, P. A. et al. 2018. Analgesic efficacy and hematologic effects of robenacoxib in mice. JAALAS 57(3), 258-267.