Publications

Pharmacokinetics of a novel, transdermal fentanyl solution in rhesus macaques (Macaca mulatta)

Rhesus macaques (Macaca mulatta) are the most commonly used NHP biomedical model and experience both research and clinical procedures requiring analgesia. Opioids are a mainstay of analgesic therapy. A novel, transdermal fentanyl solution (TFS) has been developed as a long-acting,...

Year Published: 2017Topics: AnalgesiaAnimal Type: Macaque, Nonhuman Primate

Citation: Salyards, G. W., Lemoy, M.-J., Knych, H. K. et al. 2017. Pharmacokinetics of a novel, transdermal fentanyl solution in rhesus macaques (Macaca mulatta). JAALAS 56(4), 443-451.

Uses and doses of local anesthetics in fish, amphibians, and reptiles

Local anesthetics are an integral part of routine pain management in mammals, yet their use is relatively limited in fish, amphibians and reptiles. These animals frequently undergo potentially painful surgical procedures and therefore could possibly benefit from those drugs. Some...

Year Published: 2017Topics: Analgesia, Anesthesia & SedationAnimal Type: Amphibian, Crocodile & Alligator, Fish, Frog & Toad, Lizard, Other Fish, Reptile, Salamander, Salmon, Snake, Tilapia, Trout, Turtle & Tortoise, Zebrafish

Citation: Chatigny, F., Kamunde, C., Creighton, C. M. et al. 2017. Uses and doses of local anesthetics in fish, amphibians, and reptiles. JAALAS 56(3), 244-253.

Effects of nesting material on energy homeostasis in BALB/cAnNCrl, C57BL/6NCrl, and Crl:CD1(ICR) mice housed at 20 °C

Discrepancies exist between the preferred temperature range for mice (26 to 32 °C) and current recommendations (20 to 26 °C), which may alter metabolism and negatively affect studies using mice. Previous research indicates that nesting material can alleviate cold stress...

Year Published: 2017Topics: Environmental EnrichmentAnimal Type: Mouse, Rodent

Citation: Johnson, J. S., Taylor, D. J., Green, A. R. et al. 2017. Effects of nesting material on energy homeostasis in BALB/cAnNCrl, C57BL/6NCrl, and Crl:CD1(ICR) mice housed at 20 °C. JAALAS 56(3), 254-259.

Effects of water bottle materials and filtration on bisphenol A content in laboratory animal drinking water

Bisphenol A (BPA) is widely used in the polycarbonate plastics and epoxy resins that are found in laboratory animal husbandry materials including cages and water bottles. Concerns about BPA exposure in humans has led to investigations that suggest physiologic health...

Year Published: 2017Topics: Husbandry & ManagementAnimal Type: All/General

Citation: Honeycutt, J. A., Nguyen, J. Q. T., Kentner, A. C. et al. 2017. Effects of water bottle materials and filtration on bisphenol A content in laboratory animal drinking water. JAALAS 56(3), 269-272.

Anesthetic and postanesthetic effects of alfaxalone–butorphanol compared with dexmedetomidine–ketamine in chinchillas (Chinchilla lanigera)

Effective and safe anesthetic protocols are required for a variety of surgical and diagnostic procedures in chinchillas. Alfaxalone, a new anesthetic agent in the United States, can be administered intramuscularly and subcutaneously and is therefore potentially useful as an anesthetic...

Year Published: 2017Topics: Anesthesia & SedationAnimal Type: Chinchilla, Rodent

Citation: Parkinson, L., Mans, C. 2017. Anesthetic and postanesthetic effects of alfaxalone–butorphanol compared with dexmedetomidine–ketamine in chinchillas (Chinchilla lanigera). JAALAS 56(3), 290-295.

Intraperitoneal administration of ethanol as a means of euthanasia for neonatal mice (Mus musculus)

The humane euthanasia of animals in research is of paramount importance. Neonatal mice frequently respond differently to euthanasia agents when compared with adults. The AVMA's Guidelines for the Euthanasia of Animals includes intraperitoneal injection of ethanol as "acceptable with conditions,"...

Year Published: 2017Topics: EuthanasiaAnimal Type: Mouse, Rodent

Citation: de Souza Dyer, C., Brice, A. K., Marx, J. O. 2017. Intraperitoneal administration of ethanol as a means of euthanasia for neonatal mice (Mus musculus). JAALAS 56(3), 299-306.

Comparing phlebotomy by tail tip amputation, facial vein puncture, and tail vein incision in C57BL/6 mice by using physiologic and behavioral metrics of pain and distress

Tail tip amputation with minimal restraint is not widely used for mouse phlebotomy. In part, this infrequency may reflect policies influenced by tail tip amputation procedures for genotyping, which involve greater handling and tissue removal. To assess tail tip amputation...

Year Published: 2017Topics: Biological Sampling & Physiological MeasurementAnimal Type: Mouse, Rodent

Citation: Moore, E. S., Cleland, T. A., Williams, W. O. et al. 2017. Comparing phlebotomy by tail tip amputation, facial vein puncture, and tail vein incision in C57BL/6 mice by using physiologic and behavioral metrics of pain and distress. JAALAS 56(3), 307-317.

Effect of home cage bedding in the induction chamber on serum cortisol and corticosterone levels in response to isoflurane-induced anesthesia in C57BL/6J mice

Mice are routinely anesthetized with isoflurane in an induction chamber. The AVMA Guidelines for the Euthanasia of Animals states that distress should be minimized during euthanasia but does not address this point in regard to induction of anesthesia. Here we...

Year Published: 2017Topics: Anesthesia & SedationAnimal Type: Mouse, Rodent

Citation: Reiter, C. P., Christy, A. C., Olsen, C. H. et al. 2017. Effect of home cage bedding in the induction chamber on serum cortisol and corticosterone levels in response to isoflurane-induced anesthesia in C57BL/6J mice. JAALAS 56(2), 118-121.

An efficient, simple, and noninvasive procedure for genotyping aquatic and nonaquatic laboratory animals

Various animal models are indispensible in biomedical research. Increasing awareness and regulations have prompted the adaptation of more humane approaches in the use of laboratory animals. With the development of easier and faster methodologies to generate genetically altered animals, convenient...

Year Published: 2017Topics: Identification MethodAnimal Type: Amphibian, Frog & Toad, Mouse, Rodent

Citation: Okada, M., Miller, T. C., Roediger, J. et al. 2017. An efficient, simple, and noninvasive procedure for genotyping aquatic and nonaquatic laboratory animals. JAALAS 56(5), 570-573.

Updated review of fish analgesia

Analgesics are an integral part of routine pain management in mammals, yet their use in fish is still limited. Some recommendations on the use of analgesics in fish are currently in the literature; however, information on the properties of analgesic...

Year Published: 2018Topics: AnalgesiaAnimal Type: Fish, Other Fish, Salmon, Tilapia, Trout, Zebrafish

Citation: Chatigny, F., Creighton, C. M., Stevens, E. D. 2018. Updated review of fish analgesia. JAALAS 57(1), 5-12.