Publications

Benefits of 21% oxygen compared with 100% oxygen for delivery of isoflurane to mice (Mus musculus) and rats (Rattus norvegicus)

At research institutions, isoflurane delivered by precision vaporizer to a face mask is the standard for rodent surgery and for procedures with durations that exceed a few minutes. Pure oxygen is often used as the carrier gas for isoflurane anesthesia,...

Year Published: 2017Topics: Anesthesia & SedationAnimal Type: Mouse, Rat, Rodent

Citation: Wilding, L. A., Hampel, J. A., Khoury, B. M. et al. 2017. Benefits of 21% oxygen compared with 100% oxygen for delivery of isoflurane to mice (Mus musculus) and rats (Rattus norvegicus). JAALAS 56(2), 148-154.

Effects of buprenorphine, methylnaltrexone, and their combination on gastrointestinal transit in healthy New Zealand White rabbits

Among the many analgesic agents available, buprenorphine appears to be the analgesic used most often in rabbits. Unfortunately, deleterious side effects of opioids, such as gastrointestinal stasis and anorexia, may discourage the use of these agents. Methylnaltrexone is a peripheral...

Year Published: 2017Topics: AnalgesiaAnimal Type: Rabbit

Citation: Martin-Flores, M., Singh, B., Walsh, C. A. 2017. Effects of buprenorphine, methylnaltrexone, and their combination on gastrointestinal transit in healthy New Zealand White rabbits. JAALAS 56(2), 155-159.

Pharmacokinetic profiles of meloxicam and sustained-release buprenorphine in prairie dogs (Cynomys ludovicianus)

In this study, we evaluated the pharmacokinetic profiles of meloxicam and sustained-release (SR) buprenorphine in prairie dogs. The 4 treatment groups were: low-dose meloxicam (0.2 mg/kg SC), high-dose meloxicam (4 mg/kg SC), low-dose buprenorphine SR (0.9 mg/kg SC), and high-dose...

Year Published: 2017Topics: AnalgesiaAnimal Type: Other Rodent, Rodent

Citation: Cary, C. D., Lukovsky-Akhsanov, N. L., Gallardo-Romero, N. F. et al. 2017. Pharmacokinetic profiles of meloxicam and sustained-release buprenorphine in prairie dogs (Cynomys ludovicianus). JAALAS 56(2), 160-165.

A device that allows rodents to behaviorally thermoregulate when housed in vivariums

Laboratories and vivariums typically are maintained at ambient temperatures of 20 to 24 °C, leading to cold stress in mice. When mice are inactive and sleeping during the light phase, their zone of thermoneutrality associated with a basal metabolic rate...

Year Published: 2017Topics: Husbandry & ManagementAnimal Type: Mouse, Rat, Rodent

Citation: Gordon, C. J., Puckett, E. T., Repasky, E. S. et al. 2017. A device that allows rodents to behaviorally thermoregulate when housed in vivariums. JAALAS 56(2), 173-176.

Comparison of saliva collection methods for the determination of salivary cortisol levels in rhesus macaques (Macaca mulatta), cynomolgus macaques (Macaca fascicularis), and African green monkeys (Chlorocebus aethiops)

The ability to quickly and accurately determine cortisol as a biomarker for stress is a valuable tool in assessing the wellbeing of NHP. In this study, 2 methods of collecting saliva (a commercial collection device and passive drool) and the...

Year Published: 2017Topics: Biological Sampling & Physiological MeasurementAnimal Type: Macaque, Nonhuman Primate, Vervet (African Green Monkey)

Citation: Rapp-Santos, K. J., Altamura, L. A., Norris, S. L. et al. 2017. Comparison of saliva collection methods for the determination of salivary cortisol levels in rhesus macaques (Macaca mulatta), cynomolgus macaques (Macaca fascicularis), and African green monkeys (Chlorocebus aethiops). JAALAS 56(2), 181-189.

What goes around can come around: An unexpected deleterious effect of using mouse running wheels for environmental enrichment

Environmental enrichment items such as running wheels can promote the wellbeing of laboratory mice. Growing evidence suggests that wheel running simulates exercise effects in many mouse models of human conditions, but this activity also might change other aspects of mouse...

Year Published: 2017Topics: Environmental EnrichmentAnimal Type: Mouse, Rodent

Citation: Leduc, R. Y. M., Rauw, G., Baker, G. B. et al. 2017. What goes around can come around: An unexpected deleterious effect of using mouse running wheels for environmental enrichment. JAALAS 56(2), 194-201.

Techniques for nonterminal blood sampling in black-tailed prairie dogs (Cynomys ludovicianus)

Black-tailed prairie dogs (Cynomys ludovicianus) are used as an animal model for research on gallbladder stones and several infectious diseases. A comprehensive, instructive resource regarding the appropriate techniques for venipuncture and collection of nonterminal blood samples in this species has...

Year Published: 2017Topics: Biological Sampling & Physiological MeasurementAnimal Type: Other Rodent, Rodent

Citation: Head, V., Eshar, D., Nau, M. R. 2017. Techniques for nonterminal blood sampling in black-tailed prairie dogs (Cynomys ludovicianus). JAALAS 56(2), 210-213.

Automated tracking of motion and body weight for objective monitoring of rats in colony housing

Living together in large social communities within an enriched environment stimulates self-motivated activity in rats. We developed a modular housing system in which a single unit can accommodate as many as 48 rats and contains multiple functional areas. This rat...

Year Published: 2017Topics: Environmental Enrichment, Housing, Welfare AssessmentAnimal Type: Rat, Rodent

Citation: Brenneis, C., Westhof, A., Holschbach, J. et al. 2017. Automated tracking of motion and body weight for objective monitoring of rats in colony housing. JAALAS 56(1), 18-31.

Use of liposomal bupivacaine for postoperative analgesia in an incisional pain model in rats (Rattus norvegicus)

The local anesthetic bupivacaine is valuable for perioperative analgesia, but its use in the postoperative period is limited by its short duration of action. Here, we evaluated the application of a slow-release liposomal formulation of bupivacaine for postoperative analgesia. The...

Year Published: 2017Topics: AnalgesiaAnimal Type: Rat, Rodent

Citation: Kang, S. C., Jampachaisri, K., Seymour, T. L. et al. 2017. Use of liposomal bupivacaine for postoperative analgesia in an incisional pain model in rats (Rattus norvegicus). JAALAS 56(1), 63-68.

Physiologic, behavioral, and histologic responses to various euthanasia methods in C57BL/6NTac male mice

Rodent euthanasia using exposure to increasing concentrations of CO2 has come under scrutiny due to concerns of potential pain during the euthanasia process. Alternatives to CO2, such as isoflurane and barbiturates, have been proposed as more humane methods of euthanasia....

Year Published: 2017Topics: EuthanasiaAnimal Type: Mouse, Rodent

Citation: Boivin, G. P., Bottomley, M. A., Schiml, P. A. et al. 2017. Physiologic, behavioral, and histologic responses to various euthanasia methods in C57BL/6NTac male mice. JAALAS 56(1), 69-78.