Publications

A novel welfare and scientific approach to conducting dog metabolism studies allowing dogs to be pair housed

Metabolism cages are designed to conduct absorption, distribution, metabolism and excretion (ADME) studies, enabling an ‘excretion balance’ scientific objective to be met. Historically, the design of dog metabolism cages has involved single housing. This type of housing has limitations for...

Year Published: 2020Topics: Biological Sampling & Physiological MeasurementAnimal Type: Dog

Citation: Kendrick, J., Stow, R., Ibbotson, N. et al. 2020. A novel welfare and scientific approach to conducting dog metabolism studies allowing dogs to be pair housed. Laboratory Animals 54(6), 588-598.

A persistent abnormal repetitive behaviour in a false water cobra (Hydrodynastes gigas)

Stereotypies (a subset of Abnormal Repetitive Behaviour [ARB]) are characterised by an unchanging pattern of behaviour and in captive animals can be associated with poor welfare. Although well known in certain taxa, little is known about both welfare and ARBs...

Year Published: 2020Topics: Abnormal/Problematic BehaviorAnimal Type: Reptile, Snake

Citation: Michaels, C. J., Gini, B. F., Clifforde, L. 2020. A persistent abnormal repetitive behaviour in a false water cobra (Hydrodynastes gigas). Animal Welfare 29(4), 371-378.

A rational approach of early humane endpoint determination in a murine model for cholestasis

Reduction of animal suffering during in vivo experiments is usually ensured by continuously monitoring the health status using a score sheet and by applying humane endpoints. However, most studies do not evaluate the plausibility of score sheets and do not...

Year Published: 2020Topics: Disease/Experimental Model, Humane EndpointAnimal Type: Mouse, Rodent

Citation: Zhang, X., Kumstel, S., Tang, G. et al. 2020. A rational approach of early humane endpoint determination in a murine model for cholestasis. ALTEX 37(2), 197-207.

A review of pain assessment methods in laboratory rodents

Ensuring that laboratory rodent pain is well managed underpins the ethical acceptability of working with these animals in research. Appropriate treatment of pain in laboratory rodents requires accurate assessments of the presence or absence of pain to the extent possible....

Year Published: 2020Topics: Welfare AssessmentAnimal Type: Chinchilla, Gerbil, Guinea Pig, Hamster, Mouse, Other Rodent, Rat, Rodent

Citation: Turner, P. V., Pang, D. S., Lofgren, J. L. 2019. A review of pain assessment methods in laboratory rodents. Comparative Medicine 69(6), 451–467.

A review of research in primate sanctuaries

While non-human primate studies have long been conducted in laboratories, and more recently at zoological parks, sanctuaries are increasingly considered a viable setting for research. Accredited sanctuaries in non-range countries house thousands of primates formerly used as subjects of medical...

Year Published: 2020Topics: Housing, Natural BehaviorAnimal Type: Baboon, Capuchin, Chimpanzee, Lemur, Macaque, Marmoset, Nonhuman Primate, Other Nonhuman Primate, Owl Monkey, Squirrel Monkey, Vervet (African Green Monkey)

Citation: Ross, S. R., Leinwand, J. G. 2020. A review of research in primate sanctuaries. Biology Letters 16(4), 1620200033.

A review of strain and sex differences in response to pain and analgesia in mice

Pain and its alleviation are currently a highly studied issue in human health. Research on pain and response to analgesia has evolved to include the effects of genetics, heritability, and sex as important components in both humans and animals. The...

Year Published: 2020Topics: Analgesia, Welfare AssessmentAnimal Type: Mouse, Rodent

Citation: Smith J. C. 2019. A review of strain and sex differences in response to pain and analgesia in mice. Comparative Medicine 69(6), 490–500.

A review of welfare indicators of indoor-housed dairy cow as a basis for integrated automatic welfare assessment systems

For on-farm welfare assessment many automatic methods have been developed to detect indicators of reduced welfare. However, there is still a need to integrate data from single sources to obtain a complete picture of the welfare of an animal. This...

Year Published: 2020Topics: Welfare AssessmentAnimal Type: Cattle

Citation: Leliveld, L. M. C., Provolo, G. 2020. A review of welfare indicators of indoor-housed dairy cow as a basis for integrated automatic welfare assessment systems. Animals 10(8), 1430.

Social enrichment by separated pair housing of male C57BL/6JRj mice

Laboratory male mice are often housed individually due to aggressive behavior or experimental requirements, though social isolation can cause welfare issues. As a strategy to refine housing of male mice, we introduce the separated pair housing system. A perforated transparent...

Year Published: 2020Topics: Social Housing & CompanionshipAnimal Type: Mouse, Rodent

Citation: Hohlbaum, K., Frahm, S., Rex, A. et al. 2020. Social enrichment by separated pair housing of male C57BL/6JRj mice. Scientific Reports 10, 11165.

Social isolation in rats: Effects on animal welfare and molecular markers for neuroplasticity

Early life stress compromises brain development and can contribute to the development of mental illnesses. A common animal model used to study different facets of psychiatric disorders is social isolation from early life on. In rats, this isolation can induce...

Year Published: 2020Topics: Social Housing & CompanionshipAnimal Type: Rat, Rodent

Citation: Begni, V., Sanson, A., Pfeiffer, N. et al. 2020. Social isolation in rats: Effects on animal welfare and molecular markers for neuroplasticity. PLOS ONE 15(10), e0240439.

Social referencing in the domestic horse

Dogs and cats use human emotional information directed to an unfamiliar situation to guide their behavior, known as social referencing. It is not clear whether other domestic species show similar socio-cognitive abilities in interacting with humans. We investigated whether horses...

Year Published: 2020Topics: Human-Animal InteractionAnimal Type: Equine

Citation: Schrimpf, A., Single, M., Nawroth, C. 2020. Social referencing in the domestic horse. Animals 10(1), 164.