Publications

Association of Primate Veterinarians’ Position Statement: Cerebrospinal fluid aspiration for nonhuman primates in biomedical research

The Association of Primate Veterinarians (APV) recognizes that CSF collection may be required for both clinical and research purposes in nonhuman primates (NHP). Because there are inherent risks associated with the technique, the laboratory animal veterinarian should determine the need...

Year Published: 2019Topics: Biological Sampling & Physiological MeasurementAnimal Type: Baboon, Capuchin, Chimpanzee, Lemur, Macaque, Marmoset, Nonhuman Primate, Other Nonhuman Primate, Owl Monkey, Squirrel Monkey, Vervet (African Green Monkey)

Citation: Association of Primate Veterinarians. 2019. Association of Primate Veterinarians' Position Statement: Cerebrospinal fluid aspiration for nonhuman primates in biomedical research. JAALAS 58(4), 428-429.

Identifying and implementing endpoints for geriatric mice

The types of changes in physical appearance and behavior that occur in elderly people similarly develop in elderly animals. Signs and symptoms that might cause concern in younger people or mice may be normal in their elderly but generally healthy...

Year Published: 2018Topics: Disease/Experimental Model, Humane EndpointAnimal Type: Mouse, Rodent

Citation: Toth, L. A. 2018. Identifying and implementing endpoints for geriatric mice. Comparative Medicine 68(6), 439–451.

Immunomodulatory effects of stress and environmental enrichment in Long–Evans rats (Rattus norvegicus)

Stress can influence the secretion of neuroendocrine mediators, thereby exposing immune cells to altered signaling and interactions. Here we investigated the synergetic effect of stress and environmental enrichment on the immune response of Long–Evans rats. Subjects (n = 46) were...

Year Published: 2019Topics: Environmental EnrichmentAnimal Type: Rat, Rodent

Citation: Scarola, S. J., Perdomo Trejo, J. R., Granger, M. E. et al. 2019. Immunomodulatory effects of stress and environmental enrichment in Long–Evans rats (Rattus norvegicus). Comparative Medicine 69(1), 35–47.

Monitoring the health status of mice with bleomycin-induced lung injury by using body condition scoring

Well-defined, humane endpoints aid in monitoring animal health status during disease development. Body condition scoring (BCS) is a method for assessing health status in mouse studies where wasting and death are potential endpoints. Whether BCS is useful in monitoring animals...

Year Published: 2019Topics: Disease/Experimental Model, Humane EndpointAnimal Type: Mouse, Rodent

Citation: Cowley, P. M., Roberts, C. R., Baker, A. J. 2019. Monitoring the health status of mice with bleomycin-induced lung injury by using body condition scoring. Comparative Medicine 69(2), 95–102.

A bird’s-eye view of regulatory, animal care, and training considerations regarding avian flight research

A thorough understanding of how animals fly is a central goal of many scientific disciplines. Birds are a commonly used model organism for flight research. The success of this model requires studying healthy and naturally flying birds in a laboratory...

Year Published: 2019Topics: Regulations & Ethical ReviewAnimal Type: Bird, Chicken, Finch, Fowl, Other Bird, Parrot

Citation: Baker, S. W., Tucci, E. R., Felt, S. A. et al. 2019. A bird's-eye view of regulatory, animal care, and training considerations regarding avian flight research. Comparative Medicine 69(3), 169–178.

Effects of pregnancy, outdoor access, and antifungal medication on hair loss in breeding-age female pigtailed macaques (Macaca nemestrina)

Over 18 mo, adult female pigtailed macaques (Macaca nemestrina) housed at a breeding facility in Arizona were monitored every 6 mo for alopecia. The study period coincided with the movement of a majority of animals from primarily outdoor housing to...

Year Published: 2019Topics: Abnormal/Problematic Behavior, HousingAnimal Type: Macaque, Nonhuman Primate

Citation: Kroeker, R., Chichester, L., Lee, G. H. et al. 2019. Effects of pregnancy, outdoor access, and antifungal medication on hair loss in breeding-age female pigtailed macaques (Macaca nemestrina). Comparative Medicine 69(3), 221–227.

The Animal Welfare Act and the conduct and publishing of wildlife research in the United States

In the US, the Animal Welfare Act (AWA) and its enabling regulations (AWAR) cover all warm-blooded animals used for research, testing, experimentation, or exhibition. The only exceptions, made in the enabling regulations, are for two genera of rodents and for...

Year Published: 2017Topics: Regulations & Ethical ReviewAnimal Type: All/General

Citation: Mulcahy, D. M. 2017. The Animal Welfare Act and the conduct and publishing of wildlife research in the United States. ILAR Journal 58(3), 371-378.

Agricultural animals as biomedical models: Occupational health and safety considerations

The use of agricultural animals in biomedical research is increasing. Their overall size and metabolic rate, organ size, longer gestation period, and other physiological similarities make them good candidates for animal models of human disease. There are a number of...

Year Published: 2018Topics: Handling, HousingAnimal Type: Cattle, Chicken, Equine, Fowl, Goat, Pig, Sheep

Citation: Edwards, G. L., Michael, J. A., Parks., A. 2018. Agricultural animals as biomedical models: Occupational health and safety considerations. ILAR Journal 59(2), 161-167.

Nontraditional laboratory animal species (cephalopods, fish, amphibians, reptiles, and birds)

Aquatic vertebrates and cephalopods, amphibians, reptiles, and birds offer unique safety and occupational health challenges for laboratory animal personnel. This paper discusses environmental, handling, and zoonotic concerns associated with these species.

Year Published: 2018Topics: HandlingAnimal Type: Amphibian, Bird, Cephalopod, Crocodile & Alligator, Finch, Fish, Fowl, Frog & Toad, Invertebrate, Lizard, Other Bird, Other Fish, Parrot, Reptile, Salamander, Salmon, Snake, Tilapia, Trout, Turtle & Tortoise, Zebrafish

Citation: O'Rourke, D. P., Baccanale, C. L., Stoskopf, M. K. 2018. Nontraditional laboratory animal species (cephalopods, fish, amphibians, reptiles, and birds). ILAR Journal 59(2), 168-176.

Disaster planning for animals in hazardous agent containment units

Disaster response planning for laboratory animal facilities is a time- and personnel-intensive undertaking. This article outlines numerous considerations in formulating a plan for disaster response in a high containment animal unit. The planning process is discussed around a set of...

Year Published: 2018Topics: EuthanasiaAnimal Type: All/General

Citation: Roble, G., Pullium, J., Hester, T. et al. 2018. Disaster planning for animals in hazardous agent containment units. ILAR Journal 59(2), 195–202.