Publications

Sustained release buprenorphine effectively attenuates postoperative hypersensitivity in an incisional pain model in neonatal rats (Rattus norvegicus)

Despite the need for safe and effective postoperative analgesia in neonates, research regarding pain management in neonatal rodents is relatively limited. Here, we investigate whether sustained release buprenorphine (Bup SR) effectively attenuates thermal hypersensitivity in a neonatal rat model of...

Year Published: 2021Topics: Analgesia, Disease/Experimental ModelAnimal Type: Rat, Rodent

Citation: Blaney, A., Jampachaisri, K., Huss, M. K. et al. 2021. Sustained release buprenorphine effectively attenuates postoperative hypersensitivity in an incisional pain model in neonatal rats (Rattus norvegicus). PLOS ONE 16(2), e0246213.

A suitable anaesthetic protocol for metamorphic zebrafish

Zebrafish are frequently used as a means to investigate development. These studies increasingly require repeated anaesthesia of zebrafish during juvenile (i.e. metamorphic) stages. The effects of anaesthesia during this time remain poorly studied. The aim of this study was to...

Year Published: 2021Topics: Anesthesia & SedationAnimal Type: Fish, Zebrafish

Citation: Owen, J. P., Kelsh, R. N. 2021. A suitable anaesthetic protocol for metamorphic zebrafish. PLOS ONE 16(3), e0246504.

Opportunities for refinement in neuroscience: Indicators of wellness and post-operative pain in laboratory macaques

Being able to assess pain in nonhuman primates undergoing biomedical procedures is important for preventing and alleviating pain, and for developing better guidelines to minimize the impacts of research on welfare in line with the 3Rs principle of Refinement. Nonhuman...

Year Published: 2019Topics: Welfare AssessmentAnimal Type: Macaque, Nonhuman Primate

Citation: Descovich, K. A., Richmond, S. E., Leach, M. C. et al. 2019. Opportunities for refinement in neuroscience: Indicators of wellness and post-operative pain in laboratory macaques. Alternatives to Animal Experimentation 36(4), 535-554.

Positive reinforcement training as physiotherapy for a brown capuchin (Sapajus apella)

Physiotherapy can be used to treat an animal following surgery, to help correcting abnormal gait and for treating tendon, bone or ligament damage. […] Of course, an animal can't just be given a set of exercises to follow. To carry...

Year Published: 2020Topics: Animal Training, Environmental Enrichment, Human-Animal InteractionAnimal Type: Capuchin, Nonhuman Primate

Citation: Coventry, C. 2020. Positive reinforcement training as physiotherapy for a brown capuchin (Sapajus apella). RATEL (Journal of the Association of British and Irish Wild Animal Keepers) 47(2), 16-17.

Buprenorphine, but not lidocaine, effectively attenuates post-operative thermal hypersensitivity in an incisional model in neonatal rats (Rattus norvegicus)

There is limited information on safe and effective neonatal rodent analgesia. The aim of this study was to evaluate the efficacy and duration of analgesia provided by buprenorphine (Bup) and lidocaine (Lid) in an incisional pain model. Male and female...

Year Published: 2021Topics: Analgesia, Surgery & Post-OpAnimal Type: Rat, Rodent

Citation: Katz, E. M., Huss, M. K., Jampachaisri, K. et al. 2021. Buprenorphine, but not lidocaine, effectively attenuates post-operative thermal hypersensitivity in an incisional model in neonatal rats (Rattus norvegicus). Scandinavian Journal of Laboratory Animal Science 47(1), 1-11.

Acute environmental temperature variation affects brain protein expression, anxiety and explorative behaviour in adult zebrafish

This study investigated the effect of 4-d acute thermal treatments at 18 °C, 26 °C (control) and 34 °C on the nervous system of adult zebrafish (Danio rerio) using a multidisciplinary approach based on behavioural tests and brain proteomic analysis....

Year Published: 2021Topics: Husbandry & ManagementAnimal Type: Fish, Zebrafish

Citation: Nonnis, S., Angiulli, E., Maffioli, E. et al. 2021. Acute environmental temperature variation affects brain protein expression, anxiety and explorative behaviour in adult zebrafish. Scientific Reports 11(1), 2521.

Motivation to dust-bathe of laying hens housed in cages and in aviaries

New housing systems for commercial egg production, furnished cages and non-cage systems, should improve the welfare of laying hens. In particular, thanks to the presence of a litter area, these new housing systems are thought to satisfy the dust-bathing motivation...

Year Published: 2007Topics: Environmental Enrichment, Natural BehaviorAnimal Type: Bird, Chicken

Citation: Colson, S., Arnould, C., Michel, V. 2007. Motivation to dust-bathe of laying hens housed in cages and in aviaries. Animal 1(3), 433-437.

Estimating mouse and rat use in American laboratories by extrapolation from Animal Welfare Act-regulated species

Alone among Western nations, the United States has a two-tier system for welfare protections for vertebrate animals in research. Because its Animal Welfare Act (AWA) excludes laboratory rats and mice (RM), government veterinarians do not inspect RM laboratories and RM...

Year Published: 2021Topics: Regulations & Ethical ReviewAnimal Type: Mouse, Rat, Rodent

Citation: Carbone, L. 2021. Estimating mouse and rat use in American laboratories by extrapolation from Animal Welfare Act-regulated species. Scientific Reports 11(1), 493.

Wellbeing of mice euthanized with carbon dioxide in their home cage as compared with an induction chamber

The AVMA Guidelines on Euthanasia state that, to decrease potential distress of animals, the home cage should be used for the euthanasia of mice. The current study evaluated this recommendation by comparing behavioral and physiologic changes in ICR and SJL...

Year Published: 2021Topics: EuthanasiaAnimal Type: Mouse, Rodent

Citation: Hickman, D. L. 2021. Wellbeing of mice euthanized with carbon dioxide in their home cage as compared with an induction chamber. JAALAS 60(1), 72-76.

Pharmacokinetics and efficacy of a long-lasting, highly concentrated buprenorphine solution in mice

Buprenorphine is a commonly used opioid for mitigating pain in laboratory mice after surgical procedures; however, the dosing interval necessary for standard buprenorphine may require treatment every 4 to 6 h to maintain an adequate plane of analgesia. An alternative...

Year Published: 2021Topics: AnalgesiaAnimal Type: Mouse, Rodent

Citation: Kendall, L. V., Singh, B., Bailey, A. L. et al. 2021. Pharmacokinetics and efficacy of a long-lasting, highly concentrated buprenorphine solution in mice. JAALAS 60(1), 64-71.