Publications

High-dose meloxicam provides improved analgesia in female CD1 mice: A pharmacokinetic and efficacy study

Meloxicam is a nonsteroidal anti-inflammatory analgesic drug that is often used in mice. However, doses of 1 to 5 mg/kg given twice daily were recently reported to provide inadequate analgesia. Some studies suggest that doses of up to 20 mg/kg...

Year Published: 2023Topics: AnalgesiaAnimal Type: Mouse, Rodent

Citation: Kim, J., Cannon, B. A., Freeman, L. E. et al. 2023. High-dose meloxicam provides improved analgesia in female CD1 mice: A pharmacokinetic and efficacy study. JAALAS 62(1), 74–80.

Benchmarking enrichment efforts in the US & Canada across species and enrichment categories

Enrichment is important for animal welfare and data quality. Provision of enrichment opportunities varies between species and enrichment category. However, data benchmarking these differences does not exist. Our objective was to characterize enrichment provision and associated factors across species in...

Year Published: 2023Topics: Environmental EnrichmentAnimal Type: Cat, Cattle, Chicken, Dog, Ferret, Goat, Macaque, Mink, Mouse, Nonhuman Primate, Rabbit, Rat, Rodent, Sheep

Citation: LaFollette, M. R., Cloutier, S., Brady, C. M. et al. 2023. Benchmarking enrichment efforts in the US & Canada across species and enrichment categories. JAALAS 62(4), 303–316.

Comparison of fixed and rising displacement rates of CO2 for euthanasia of aged rats

This study compared euthanasia induced by rising concentrations of CO2 in aged rats (n = 59) using different gas displacement rates. Rats were preimplanted with cardiovascular telemetry devices and had been previously used for short term safety pharmacology studies. Once...

Year Published: 2023Topics: EuthanasiaAnimal Type: Rat, Rodent

Citation: McNamara, A., Ballantine, A. R., Deuchande, R. et al. 2023. Comparison of fixed and rising displacement rates of CO2 for euthanasia of aged rats. JAALAS 62(5), 453–463.

Investigation of potassium chloride for euthanasia of anesthetized African clawed frogs (Xenopus laevis)

Euthanasia is frequently performed in amphibians, but techniques are currently limited in number and variable in effectiveness. The current study examined the use of potassium chloride (KCl) for euthanasia of anesthetized African clawed frogs (Xenopus laevis). Twenty adult, female African...

Year Published: 2023Topics: EuthanasiaAnimal Type: Amphibian, Frog & Toad

Citation: Olagbaju, T. T., Troan, B. V., Balko, J. A. 2023. Investigation of potassium chloride for euthanasia of anesthetized African clawed frogs (Xenopus laevis). JAALAS 62(4), 362–369.

Effects of human observer presence on pain assessment using facial expressions in rabbits

The goal of this study was to evaluate the effect of a human observer on Rabbit Grimace Scale (RbtGS) scores. The study scored video footage taken of 28 rabbits before and after orthopedic surgery, as follows: 24 h before surgery...

Year Published: 2023Topics: Welfare AssessmentAnimal Type: Rabbit

Citation: Pinho, R. H., Justo, A. A., Cima, D. S. et al. 2023. Effects of human observer presence on pain assessment using facial expressions in rabbits. JAALAS 62(1), 81–86.

Method of measuring effects of study procedures in single and pair housed New Zealand White rabbits (Oryctolagus cuniculus)

Social housing of laboratory rabbits is encouraged and thought to improve animal welfare due to the social nature of this species. However, there is limited published information comparing the physiologic and cardiovascular (CV) effects of paired and single housed adult...

Year Published: 2023Topics: Social Housing & CompanionshipAnimal Type: Rabbit

Citation: Santos, R. V., Bhatt, S., Foote, S. et al. 2023. Method of measuring effects of study procedures in single and pair housed New Zealand White rabbits (Oryctolagus cuniculus). Journal of Pharmacological and Toxicological Methods 119, 107204.

Acetaminophen pharmacokinetics in geese

OBJECTIVE To evaluate the pharmacokinetics of acetaminophen (APAP) after single-dose IV and PO in the goose; to quantify APAP and its main metabolites in goose muscle, heart, lung, liver, and kidney; and to perform a histopathologic evaluation of goose stomach,...

Year Published: 2022Topics: AnalgesiaAnimal Type: Bird, Fowl

Citation: Sartini, I., Łebkowska-Wieruszewska, B., Gbylik-Sikorska, M. et al. 2022. Acetaminophen pharmacokinetics in geese. Journal of the American Veterinary Medical Association 260(12), 1–8.

Enrichment sessions as a complementary therapy for hospitalized cats: Implications for stress reduction and sporotrichosis’ lesion recovery

Sporotrichosis treatment in cats requires long-term isolation of infected animals. The aim of this study is to evaluate the effect of environmental enrichment sessions on the behaviour and lesion progression of cats hospitalized for sporotrichosis treatment. Ten cats were divided...

Year Published: 2023Topics: Environmental EnrichmentAnimal Type: Cat

Citation: Sato, S. T. M., de Farias, M. R., Daros, R. R. 2023. Enrichment sessions as a complementary therapy for hospitalized cats: Implications for stress reduction and sporotrichosis' lesion recovery. Applied Animal Behaviour Science 269, 106114.

Feline faces: Unraveling the social function of domestic cat facial signals

Lately, there has been a growing interest in studying domestic cat facial signals, but most of this research has centered on signals produced during human-cat interactions or pain. The available research on intraspecific facial signaling with domesticated cats has largely...

Year Published: 2023Topics: Human-Animal Interaction, Natural BehaviorAnimal Type: Cat

Citation: Scott, L., Florkiewicz, B. N. 2023. Feline faces: Unraveling the social function of domestic cat facial signals. Behavioural Processes 213, 104959.

Effects of different handling methods on the behavior of adult zebrafish

The zebrafish is an important biomedical research organism. In most research, zebrafish are removed from their home tank and subsequently their phenotype is measured. The method of handling the fish, however, may significantly affect a variety of phenotypes. This is...

Year Published: 2023Topics: HandlingAnimal Type: Fish, Zebrafish

Citation: Shishis, S., Tsang, B., Ren, G. J. et al. 2023. Effects of different handling methods on the behavior of adult zebrafish. Physiology & Behavior 262, 114106.