Publications

Use of a low-calorie flavored gel to facilitate oral self-administration of analgesics in mice

The goals of this study were to determine whether mice would adapt to a low-calorie flavored water gel as their sole source of hydration and whether the addition of acetaminophen, tramadol, meloxicam, or buprenorphine to the gel would affect their...

Year Published: 2023Topics: Analgesia, Drug/Substance AdministrationAnimal Type: Mouse, Rodent

Citation: Riddell, D. L., Hyndman, T. H., Bowden, R. S. et al. 2023. Use of a low-calorie flavored gel to facilitate oral self-administration of analgesics in mice. JAALAS 62(2), 163–169.

Effects of different grades of carbon dioxide on euthanasia of mice (Mus musculus)

Carbon dioxide (CO2) is a conditionally acceptable method for mouse euthanasia, according to the American Veterinary Medical Association Guidelines for the Euthanasia of Animals. In a 2012 Office of Laboratory Animal Welfare (OLAW) webinar, representatives of OLAW, the USDA and...

Year Published: 2023Topics: EuthanasiaAnimal Type: Mouse, Rodent

Citation: Stuckey, J. E., Makhija, S. D., Reimer, D. C. et al. 2023. Effects of different grades of carbon dioxide on euthanasia of mice (Mus musculus). JAALAS 62(5), 430–437.

Evaluation of cage mate–induced postsurgical trauma in mice

Although mice are social animals, individual housing is sometimes requested after surgery. We questioned whether pair-housing mice after surgery resulted in greater trauma to the surgical site as compared with single housing. We further evaluated the effect of individual housing...

Year Published: 2023Topics: Social Housing & Companionship, Surgery & Post-OpAnimal Type: Mouse, Rodent

Citation: Tirado-Muñiz, N., Spangler, T. L., Van Rooyen, H. et al. 2023. Evaluation of cage mate–induced postsurgical trauma in mice. JAALAS 62(2), 170–178.

Enriched environment during adolescence modulates lipid metabolism and emotion-related behaviors in mice

Enriched environment (EE) is an important animal experimental paradigm to decipher gene-environment interaction. It is thought to be efficient in aiding recovery from certain metabolism disorders or cognitive impairments. Recently, the effects of EE during adolescence in mice gradually draw...

Year Published: 2023Topics: Environmental EnrichmentAnimal Type: Mouse, Rodent

Citation: Xu, L., Jiao, M., Cui, Z.-L. et al. 2023. Enriched environment during adolescence modulates lipid metabolism and emotion-related behaviors in mice. Journal of Applied Animal Welfare Science 26(2), 218–228.

An optimized method for intratracheal instillation in mice

Non-invasive intratracheal instillation is an important method for direct exposure of the respiratory tract which is commonly used in toxicology, environmental science, and other research fields. However, there is no standard operating process for non-invasive intratracheal instillation. To keep the...

Year Published: 2022Topics: Disease/Experimental Model, Drug/Substance AdministrationAnimal Type: Mouse, Rodent

Citation: Zeng, Y., Jin, H., Wang, J. et al. 2022. An optimized method for intratracheal instillation in mice. Journal of Pharmacological and Toxicological Methods 118, 107230.

The effect of short-term classical music stimulus on behavior and tonic immobility reaction of pullets

The purpose of this study was to investigate the effect of short-term stimulation of classical music on the behavior of pullets and to explore whether classical music as an auditory enrichment factor reduces the fear level in pullets. One hundred...

Year Published: 2023Topics: Environmental EnrichmentAnimal Type: Chicken

Citation: Zhao, S., Zhang, R., Li, C. et al. 2023. The effect of short-term classical music stimulus on behavior and tonic immobility reaction of pullets. Journal of Applied Animal Welfare Science 26(3), 386–392.

Noninvasive monitoring of blood pressure and heart rate during estrous cycle phases in bormotensive Wistar–Kyoto and spontaneously hypertensive female rats

Since 2015, the National Institutes of Health has called for its funded preclinical research to include both male and female subjects. However, much of the basic animal research that has studied heart rate and blood pressure in the past has...

Year Published: 2023Topics: Biological Sampling & Physiological MeasurementAnimal Type: Rat, Rodent

Citation: Ayala-Méndez, G. X., Calderón, V. M., Zuñiga-Pimentel, T. A. et al. 2023. Noninvasive monitoring of blood pressure and heart rate during estrous cycle phases in bormotensive Wistar–Kyoto and spontaneously hypertensive female rats. JAALAS 62(3), 267–273.

Evaluation of ambient sound, vibration, and light in rodent housing rooms

Excessive sound, vibration, and light are detrimental to rodent welfare, yet these parameters are rarely recorded in vivaria. Whether housing environments exceed the suggested thresholds and which specific factors may alter these parameters is generally unknown. The goal of this...

Year Published: 2022Topics: Husbandry & ManagementAnimal Type: Mouse, Rat, Rodent

Citation: Barabas, A. J., Darbyshire, A. K., Schlegel, S. L. et al. 2022. Evaluation of ambient sound, vibration, and light in rodent housing rooms. JAALAS 61(6), 660–671.

Pinna edge biopsy of 7 and 21 day old C57BL/6 mice as a method for identification and genotyping

Identifying and genotyping mice prior to weaning can be useful for mouse colony management. Mice of an undesired genotype can be identified prior to weaning and removed from further study, resulting in a reduction of housing costs, and labor time....

Year Published: 2023Topics: Identification MethodAnimal Type: Mouse, Rodent

Citation: Chen, D. D., Molk, D. M., Palley, L. S. et al. 2023. Pinna edge biopsy of 7 and 21 day old C57BL/6 mice as a method for identification and genotyping. JAALAS 62(5), 438–448.

Effects of housing density on reproductive performance, intracage ammonia, and welfare of mice continuously housed as breeders in standard mouse and rat caging

Maintaining compliance with cage density recommendations in The Guide for the Care and Use of Laboratory Animals precludes continuous trio breeding in standard-sized mouse cages. This study evaluated and compared several parameters of reproductive performance, intracage ammonia concentration, and fecal...

Year Published: 2023Topics: Husbandry & Management, Reproduction, Stocking DensityAnimal Type: Mouse, Rodent

Citation: Cho, E., Walsh, C. A., D'Angelo-Gavrish, N. M. et al. 2023. Effects of housing density on reproductive performance, intracage ammonia, and welfare of mice continuously housed as breeders in standard mouse and rat caging. JAALAS 62(2), 116–122.