Rodent

PCR testing of IVC filter tops as a method for detecting murine pinworms and fur mites

We evaluated PCR testing of filter tops from cages maintained on an IVC system through which exhaust air is filtered at the cage level as a method for detecting parasite-infected and -infested cages. Cages containing 4 naïve Swiss Webster mice...

Year Published: 2017Topics: Husbandry & ManagementAnimal Type: Mouse, Rodent

Citation: Gerwin, P. M., Ricart Arbona, R. J., Riedel, E. R. et al. 2017. PCR testing of IVC filter tops as a method for detecting murine pinworms and fur mites. JAALAS 56(6), 752-761.

Pharmacokinetics and adverse effects of 3 sustained-release buprenorphine dosages in healthy guinea pigs (Cavia porcellus)

In guinea pigs, studies addressing the efficacy, safety, and pharmacokinetic profiles of different sustained-release buprenorphine (SRB) formulations are still in their infancy. Here we assessed the pharmacokinetic profiles of 3 SRB dosages (SR-LAB, ZooPharm; SRBLow, 0.15 mg/kg; SRBMedium, 0.3 mg/kg;...

Year Published: 2017Topics: AnalgesiaAnimal Type: Guinea Pig, Rodent

Citation: Zanetti, A. S., Putta, S. K., Casebolt, D. B. et al. 2017. Pharmacokinetics and adverse effects of 3 sustained-release buprenorphine dosages in healthy guinea pigs (Cavia porcellus). JAALAS 56(6), 768-778.

Effects of repeated intraperitoneal injection of pharmaceutical-grade and nonpharmaceutical-grade corn oil in female C57BL/6J mice

Due to potential adverse effects on animal wellbeing, the use of nonpharmaceutical-grade substances in animal research must be scientifically justified in cases where a pharmaceutical-grade version of the substance exists. This requirement applies to all substances, including vehicles used to...

Year Published: 2017Topics: Drug/Substance AdministrationAnimal Type: Mouse, Rodent

Citation: Hubbard, J. S., Chen, P. H., Boyd, K. L. 2017. Effects of repeated intraperitoneal injection of pharmaceutical-grade and nonpharmaceutical-grade corn oil in female C57BL/6J mice. JAALAS 56(6), 779-785.

Heating pad performance and efficacy of 2 durations of warming after isoflurane anesthesia of Sprague–Dawley rats (Rattus norvegicus)

Anesthetic agents depress thermoregulatory mechanisms, causing hypothermia within minutes of induction of general anesthesia. The consequences of hypothermia include delayed recovery and increased experimental variability. Even when normothermia is maintained during anesthesia, hypothermia may occur during recovery. The primary aim...

Year Published: 2017Topics: Anesthesia & SedationAnimal Type: Rat, Rodent

Citation: Zhang, E. Q., Knight, C. G., Pang, D. S. J. 2017. Heating pad performance and efficacy of 2 durations of warming after isoflurane anesthesia of Sprague–Dawley rats (Rattus norvegicus). JAALAS 56(6), 786-791.

Review of CO2 as a euthanasia agent for laboratory rats and mice

Selecting an appropriate, effective euthanasia agent is controversial. Several recent publications provide clarity on the use of CO2 in laboratory rats and mice. This review examines previous studies on CO2 euthanasia and presents the current body of knowledge on the...

Year Published: 2017Topics: EuthanasiaAnimal Type: Mouse, Rat, Rodent

Citation: Boivin, G. P., Hickman, D. L., Creamer-Hente, M. A. et al. 2017. Review of CO2 as a euthanasia agent for laboratory rats and mice. JAALAS 56(5), 491-499.

Quantification of induced hypothermia from aseptic scrub applications during rodent surgery preparation

Laboratory mice (Mus musculus) are prone to develop hypothermia during anesthesia for surgery, thus potentially impeding anesthetic recovery, wound healing, and future health. The core body temperatures of isoflurane-anesthetized mice are influenced by the choice of supplemental heat sources; however,...

Year Published: 2017Topics: Anesthesia & SedationAnimal Type: Mouse, Rodent

Citation: Skorupski, A. M., Zhang, J., Ferguson, D. et al. 2017. Quantification of induced hypothermia from aseptic scrub applications during rodent surgery preparation. JAALAS 56(5), 562-569.

Use of air-activated thermal devices during recovery after surgery in mice

Laboratory mice (Mus musculus) are susceptible to hypothermia, especially during anesthetic events, disease states, and exposure to environmental stressors. Thermal support devices for small mammals are numerous, but often require a power source and may be impractical to use for...

Year Published: 2018Topics: Surgery & Post-OpAnimal Type: Mouse, Rodent

Citation: Beale, C. N., Esmail, M. Y., Aguiar, A. M. et al. 2018. Use of air-activated thermal devices during recovery after surgery in mice. JAALAS 57(4), 392-400.

Effect of environmental enrichment on aggression in BALB/cJ and BALB/cByJ mice monitored by using an automated system

Aggression among mice remains a common undesirable problem in laboratory settings, and animal welfare and scientific outcomes may become compromised depending on the severity of aggression. This study evaluated the effect of cage enrichment comprising a bilevel, mounted 'mezzanine' compared...

Year Published: 2018Topics: Environmental EnrichmentAnimal Type: Mouse, Rodent

Citation: Giles, J. M., Whitaker, J. W., Moy, S. S. et al. 2018. Effect of environmental enrichment on aggression in BALB/cJ and BALB/cByJ mice monitored by using an automated system. JAALAS 57(3), 236-243.

Analgesic efficacy and hematologic effects of robenacoxib in mice

NSAID analgesics may confound models that require inflammation to mimic disease development in humans. This effect presents a challenge for veterinary staff and investigators, because surgery is often necessary to create mouse models of disease and NSAID are first-line analgesics...

Year Published: 2018Topics: AnalgesiaAnimal Type: Mouse, Rodent

Citation: Beninson, J. A., Lofgren, J. L., Lester, P. A. et al. 2018. Analgesic efficacy and hematologic effects of robenacoxib in mice. JAALAS 57(3), 258-267.

Analgesic efficacy and safety of buprenorphine in chinchillas (Chinchilla lanigera)

Buprenorphine is routinely used in chinchillas at reported doses of 0.01 to 0.1 mg/kg IM or SC. However, these dose recommendations are based on anecdotal reports or extrapolation from studies in other species. Therefore, the purpose of this study was...

Year Published: 2018Topics: AnalgesiaAnimal Type: Chinchilla, Rodent

Citation: Fox, L., Mans, C. 2018. Analgesic efficacy and safety of buprenorphine in chinchillas (Chinchilla lanigera). JAALAS 57(3), 286-290.