Rodent

Sustained-release buprenorphine improves postsurgical clinical condition but does not alter survival or cytokine levels in a murine model of polymicrobial sepsis

Cecal ligation and perforation (CLP) is a common technique for studying sepsis in mice. Because of the invasiveness of the procedure and its effects on clinical condition, many animal care and use committees require the use of analgesics with CLP....

Year Published: 2016Topics: Analgesia, Disease/Experimental ModelAnimal Type: Mouse, Rodent

Citation: Herndon, N. L., Bandyopadhyay, S., Hod, E. A. et al. 2016. Sustained-release buprenorphine improves postsurgical clinical condition but does not alter survival or cytokine levels in a murine model of polymicrobial sepsis. Comparative Medicine 66(6), 455–462.

Humane endpoints for guinea pigs used for Mycobacterium tuberculosis vaccine research

Guinea pigs are a commonly used model for tuberculosis vaccine research. Loss of body weight is the most frequently described humane endpoint for animals used in these studies. During a chronic study, we noted labored breathing in some tuberculosis-infected guinea...

Year Published: 2018Topics: Disease/Experimental Model, Humane EndpointAnimal Type: Guinea Pig, Rodent

Citation: Collymore, C., Kent, L., Ahn, S. K. et al. 2018. Humane endpoints for guinea pigs used for Mycobacterium tuberculosis vaccine research. Comparative Medicine 68(1), 41–47.

Cohousing male mice with and without segmental bone defects

Spaceflight results in bone loss like that associated with osteoporosis or decreased weight-bearing (for example, high-energy trauma such as explosive injuries and automobile accidents). Thus, the unique spaceflight laboratory on the International Space Station presents the opportunity to test bone...

Year Published: 2018Topics: Disease/Experimental Model, Social Housing & CompanionshipAnimal Type: Mouse, Rodent

Citation: Rytlewski, J. D., Childress, P. J., Scofield, D. C. et al. 2018. Cohousing male mice with and without segmental bone defects. Comparative Medicine 68(2), 131–138.

Effects of rodent thermoregulation on animal models in the research environment

To best promote animal wellbeing and the efficacy of biomedical models, scientific, husbandry, and veterinary professionals must consider the mechanisms, influences, and outcomes of rodent thermoregulation in contemporary research environments. Over the last 2 decades, numerous studies have shown that...

Year Published: 2018Topics: Anesthesia & Sedation, Environmental EnrichmentAnimal Type: Mouse, Rat, Rodent

Citation: Hankenson, F. C., Marx, J. O., Gordon, C. J. et al. 2018. Effects of rodent thermoregulation on animal models in the research environment. Comparative Medicine 68(6), 425–438.

The effects of environmental enrichment and social isolation and their reversion on anxiety and fear conditioning

Animal models of fear and anxiety provide important insight into anxiety-related symptoms in humans. Environmental physical conditions and social contact influence behavior and brain plasticity particularly at early developmental stages and have long lasting effects reaching even adulthood. The potential...

Year Published: 2019Topics: Environmental EnrichmentAnimal Type: Rat, Rodent

Citation: Mora-Gallegos, A., Fornaguera, J. 2019. The effects of environmental enrichment and social isolation and their reversion on anxiety and fear conditioning. Behavioural Processes 158, 59-69.

The impact of changeability of enriched environment on exploration in rats

Although the positive effect of environmental enrichment on animals' cognitive capacities is well-known, it remains unclear what role changeability plays in this context. Our study aims to analyse the impact of environmental changeability on the level of exploration and the...

Year Published: 2019Topics: Environmental EnrichmentAnimal Type: Rat, Rodent

Citation: Modlinska, K., Chrzanowska, A., Pisula, W. 2019. The impact of changeability of enriched environment on exploration in rats. Behavioural Processes 164, 78-85.

Return to home cage’ as a reward for maze learning in young and old genetically heterogeneous mice

Recent studies have shown that 'return to home cage' can serve as a reward for maze learning in adult male mice. The present study examined whether the same reward is an effective motivator of learning in young and old mice...

Year Published: 2006Topics: Animal TrainingAnimal Type: Mouse, Rodent

Citation: Blizard, D. A., Weinheimer, V. K, Klein, L. C. et al. 2006. 'Return to home cage' as a reward for maze learning in young and old genetically heterogeneous mice. Comparative Medicine 56(3), 196-201.

Returning to home cage serves as an effective reward for maze learning in rats

This study examined the effectiveness in rats of ‘returning to home cage' as a reward for learning a Lashley III maze. Rats could return to their home cage directly (Direct HC group) or they could be removed manually by an...

Year Published: 2019Topics: Animal TrainingAnimal Type: Rat, Rodent

Citation: Taniuchi, T., Ohgi, A., Nishikawa, M. 2019. Returning to home cage serves as an effective reward for maze learning in rats. Behavioural Processes 164, 175-177.

Music exposure attenuates anxiety- and depression-like behaviors and increases hippocampal spine density in male rats

Epidemiological and clinical studies suggest that early-life stress (ELS) may lead to the development of mental disorders in adulthood. Maternal separation (MS) is a valid animal model of ELS that produces detrimental effects on brain and behavior of experimental animals....

Year Published: 2019Topics: Environmental EnrichmentAnimal Type: Rat, Rodent

Citation: Papadakakis, A., Sidiropoulou, K., Panagis, G. 2019. Music exposure attenuates anxiety- and depression-like behaviors and increases hippocampal spine density in male rats. Behavioural Brain Research 372, 112023.

Loss of control over mild aversive events produces significant helplessness in mice

This article is about the importance of giving mice control over what happens to them. Most of the pathophysiology of depression are still unknown because of its numerous disease states of distinct etiology and pathogenesis. Stressful rodent models have been...

Year Published: 2019Topics: Husbandry & ManagementAnimal Type: Mouse, Rodent

Citation: Yao, L., Li, Y., Qian, Z. et al. 2019. Loss of control over mild aversive events produces significant helplessness in mice. Behavioural Brain Research 376, 112173.