Rodent

Quantification of hair corticosterone, DHEA and testosterone as a potential tool for welfare assessment in male laboratory mice

Steroids, providing information regarding several biological patterns including stress and sexual behavior, have been investigated in different matrices in laboratory mice. Data regarding hair quantification, indicative of longer timespans when compared to blood and saliva, are lacking. The aim of...

Year Published: 2020Topics: Biological Sampling & Physiological Measurement, Welfare AssessmentAnimal Type: Mouse, Rodent

Citation: Elmi, A., Galligioni, V., Govoni, N. et al. 2020. Quantification of hair corticosterone, DHEA and testosterone as a potential tool for welfare assessment in male laboratory mice. Animals 10(12), 2408.

Fasting of male mice – Effects of time point of initiation and duration on clinical chemistry parameters and animal welfare

Fasting of mice is a common procedure, which can affect the outcome of the study as well as animal welfare. In this study, we assess the effects of fasting, fasting duration and fasting initiation time in relation to light schedule...

Year Published: 2019Topics: Disease/Experimental Model, Husbandry & ManagementAnimal Type: Mouse, Rodent

Citation: Jensen, T. L., Kiersgaard, M. K., Mikkelsen, L. F. et al. 2019. Fasting of male mice – Effects of time point of initiation and duration on clinical chemistry parameters and animal welfare. Laboratory Animals 53(6), 587–597.

Attempting enrichment harmonization across multiple sites and embracing our differences

A glabal enrichment committee incorporates active members from each of the company's 6 sites and works towards harmonization of enrichment practices. One of the hot topics is attempting to standardize mouse enrichment and social housing practices. This has proven to...

Year Published: 2018Topics: Environmental Enrichment, Social Housing & CompanionshipAnimal Type: Mouse, Rodent

Citation: Allen, C., Duggan, L., Fox, M. et al. 2018. Attempting enrichment harmonization across multiple sites and embracing our differences. Laboratory Animal Science Professional 5(4) (December), 48-51.

An inexpensive approach to social housing enrichment for laboratory rabbits and guinea pigs

We analyzed our current enrichment protocols in order to develop and implement social experiences for our rabbit and guinea pig colonies. This article describes the development of an exercise pen for rabbits and a custom-made social housing enclosure for guinea...

Year Published: 2013Topics: Social Housing & CompanionshipAnimal Type: Guinea Pig, Rabbit, Rodent

Citation: Rose, A. M. 2013. An inexpensive approach to social housing enrichment for laboratory rabbits and guinea pigs. Laboratory Animal Science Professional 1(4) (December), 46-48.

Playtime! Exploring habituation techniques in laboratory rats

Our rat training program teaches the standard method of handling and restraining that involves picking the rat up by the base of the tail and placing it on the wire mesh to be restrained. We observed that there was excessive...

Year Published: 2019Topics: HandlingAnimal Type: Rat, Rodent

Citation: Low, D. D., Leong Peng, J. Z., Tay, Y. Q. et al. 2019. Playtime! Exploring habituation techniques in laboratory rats. Laboratory Animal Science Professional 7(4) (December), 42-45.

Fight Club: Using housing conditions to curb male cage aggression

Those who have worked with C57BL/6 males know how aggressive they can be towards their cage mates. We poured over academic journals, reading every article we could find regarding male home cage aggression. Three articles piqued our interest and suggested...

Year Published: 2019Topics: Environmental Enrichment, Social Housing & CompanionshipAnimal Type: Mouse, Rodent

Citation: Sherrill, C., Kavanagh, K. 2019. Fight Club: Using housing conditions to curb male cage aggression. Laboratory Animal Science Professional 7(1) (March), 38-40.

Use of more naturalistic nesting material helps decrease food shredding in mice

Shredding of feed (food grinding or food wasting) is a common behavior among certain strains of mice. It is seen in both captive and wild rodents and may either be an abnormal behavior or a normal behavior that is simply...

Year Published: 2019Topics: Environmental EnrichmentAnimal Type: Mouse, Rodent

Citation: MacDuff, A., Loera, F., Adamson, T. W. 2019. Use of more naturalistic nesting material helps decrease food shredding in mice. Laboratory Animal Science Professional 7(1) (March), 46-48.

Comparison of pre-emptive butorphanol or metamizole with ketamine +medetomidine and s-ketamine + medetomidine anaesthesia in improving intraoperative analgesia in mice

In accordance with the ‘refinement' component of the 3Rs, the primary aim of this study was to investigate and compare ketamine + medetomidine (KM) and s-ketamine + medetomidine (SKM) anaesthetic protocols in C57BL/6J mice (both sexes). We sought to determine whether s-ketamine could provide...

Year Published: 2019Topics: Analgesia, Anesthesia & SedationAnimal Type: Mouse, Rodent

Citation: Bauer, C., Schillinger, U., Brandl, J. et al. 2019. Comparison of pre-emptive butorphanol or metamizole with ketamine +medetomidine and s-ketamine + medetomidine anaesthesia in improving intraoperative analgesia in mice. Laboratory Animals 53(5), 459–469.

Implementing strategies to reduce singly housed male mice

There are different husbandry situations that lead to social isolation of male mice. Besides legal considerations, single housing has a negative impact on behavioural and molecular studies. We have implemented two strategies, the ‘companion mouse' and just-weaned male grouping, to...

Year Published: 2019Topics: Social Housing & CompanionshipAnimal Type: Mouse, Rodent

Citation: Azkona, G., Caballero, J. M. 2019. Implementing strategies to reduce singly housed male mice. Laboratory Animals 53(5), 508–510.

Home sweet home cage

This feature describes creative ways in which technology can be used to study animals within their home cages, eliminating the need to handle, restrain, and separate them from cage mates. One example includes voluntary brain imaging in mice. In biomedical...

Year Published: 2018Topics: Imaging & Electrophysiological RecordingAnimal Type: Mouse, Rat, Rodent

Citation: Neff, E. P. 2018. Home sweet home cage. Lab Animal 47(10), 261–264.