Rodent

Buprenorphine in rats: Potent analgesic or trigger for fatal side effects?

With ongoing animal welfare efforts, multimodal analgesia is often recommended to implement in study protocols. Buprenorphine with very potent analgesic effect is a standard opioid for the use in this context in rats. In this study, two rat strains (LEW/NHanZtm,...

Year Published: 2022Topics: Analgesia, Surgery & Post-OpAnimal Type: Rat, Rodent

Citation: Reifenrath, J., Heider, M., Kempfert, M. et al. 2022. Buprenorphine in rats: Potent analgesic or trigger for fatal side effects? Acta Veterinaria Scandinavica 64(1), 37.

Using bioluminescence to image gene expression and spontaneous behavior in freely moving mice

Bioluminescence imaging (BLI) of gene expression in live animals is a powerful method for monitoring development, tumor growth, infections, healing, and other progressive, long-term biological processes. BLI remains an effective approach for reducing the number of animals needed to monitor...

Year Published: 2023Topics: Imaging & Electrophysiological RecordingAnimal Type: Mouse, Rodent

Citation: Malik, A., Zavadil, J. A., Geusz, M. E. 2023. Using bioluminescence to image gene expression and spontaneous behavior in freely moving mice. PLOS ONE 18(1), e0279875.

Social play experience in juvenile rats is indispensable for appropriate socio-sexual behavior in adulthood in males but not females

Social play is a dynamic and rewarding behavior abundantly expressed by most mammals during the juvenile period. While its exact function is debated, various rodent studies on the effects of juvenile social isolation suggest that participating in play is essential...

Year Published: 2023Topics: Natural Behavior, Social Housing & CompanionshipAnimal Type: Rat, Rodent

Citation: Marquardt, A. E., VanRyzin, J. W., Fuquen, R. W. et al. 2023. Social play experience in juvenile rats is indispensable for appropriate socio-sexual behavior in adulthood in males but not females. Frontiers in Behavioral Neuroscience 16, 1076765.

Exposure to soiled bedding reduces abnormal repetitive behaviors in mice

Hygiene management protocols in laboratory mouse husbandries worldwide most commonly employ soiled bedding-exposed sentinel mice to monitor the occurrence of infections in mouse colonies. Using this approach, sentinel mice repeatedly receive a mixture of used bedding, supplied by a variety...

Year Published: 2022Topics: Abnormal/Problematic Behavior, Housing, Husbandry & ManagementAnimal Type: Mouse, Rodent

Citation: Müller, K., Lengheimer, T., Kral-Pointner, J. B. et al. 2022. Exposure to soiled bedding reduces abnormal repetitive behaviors in mice. Frontiers in Behavioral Neuroscience 16, 1062864.

Development of a 3D simulator for training the mouse in utero electroporation

In utero electroporation (IUE) requires high-level training in microinjection through the mouse uterine wall into the lateral ventricle of the mouse brain. Training for IUE is currently being performed in live mice as no artificial models allow simulations yet. This...

Year Published: 2022Topics: Disease/Experimental Model, Drug/Substance Administration, ReproductionAnimal Type: Mouse, Rodent

Citation: Nuber, M., Gonzalez-Uarquin, F., Neufurth, M. et al. 2022. Development of a 3D simulator for training the mouse in utero electroporation. PLOS ONE 17(12), e0279004.

The effects of age, size, and cage complexity on the behaviour of farmed female chinchillas (Chinchilla lanigera)

Even though chinchillas have been farmed for a century, there are not many studies concerning their behaviour in captivity or their optimal housing conditions, both of which are important factors in the assessment of their welfare. This study aimed to...

Year Published: 2023Topics: Environmental Enrichment, Housing, Husbandry & ManagementAnimal Type: Chinchilla, Rodent

Citation: Łapiński, S., Niedbała, P., Markowska, K. et al. 2023. The effects of age, size, and cage complexity on the behaviour of farmed female chinchillas (Chinchilla lanigera). Scientific Reports 13(1), 6108.

Stress evaluation of mouse husbandry environments for improving laboratory animal welfare

Animal welfare is recognized as essential for the coexistence of humans and animals. Considering the increased demand and interest in animal welfare, many methods for improving animal welfare are being devised, but which method reduces animal stress has not been...

Year Published: 2023Topics: Environmental Enrichment, HousingAnimal Type: Mouse, Rodent

Citation: Lee, G.-H., Kim, K., Jo, W. 2023. Stress evaluation of mouse husbandry environments for improving laboratory animal welfare. Animals 13(2), 249.

Seminatural environments for rodent behavioral testing: A representative design improving animal welfare and enhancing replicability

The low replicability of scientific studies has become an important issue. One possible cause is low representativeness of the experimental design employed. Already in the 1950's, Egon Brunswick pointed out that experimental setups ideally should be based on a random...

Year Published: 2023Topics: Housing, Husbandry & Management, Natural BehaviorAnimal Type: Rat, Rodent

Citation: Hernández-Arteaga, E., Ågmo, A. 2023. Seminatural environments for rodent behavioral testing: A representative design improving animal welfare and enhancing replicability. Frontiers in Behavioral Neuroscience 17, 1192213.

Rating enrichment items by female group-housed laboratory mice in multiple binary choice tests using an RFID-based tracking system

Laboratory mice spend most of their lives in cages, not experiments, so improving housing conditions is a first-choice approach to improving their welfare. Despite the increasing popularity of enrichment, little is known about the benefits from an animal perspective. For...

Year Published: 2023Topics: Environmental Enrichment, HousingAnimal Type: Mouse, Rodent

Citation: Hobbiesiefken, U., Urmersbach, B., Jaap, A. et al. 2023. Rating enrichment items by female group-housed laboratory mice in multiple binary choice tests using an RFID-based tracking system. PLOS ONE 18(1), e0278709.

Effects of castration and sterilization on baseline and response levels of cortisol—A case study in male guinea pigs

An uncontrolled reproduction of animals in human hands should be avoided. To meet this goal, animals are widely castrated, i.e., the gonads are completely removed. Since the gonads are the most important source of sex hormones, this is a serious...

Year Published: 2023Topics: Body Modification/Mutilation, ReproductionAnimal Type: All/General, Guinea Pig, Rodent

Citation: Kaiser, S., Korte, A., Wistuba, J. et al. 2023. Effects of castration and sterilization on baseline and response levels of cortisol—A case study in male guinea pigs. Frontiers in Veterinary Science 9, 1093157.