Rodent

Non-invasive sampling methods for genotyping: Improvements towards the 4r principle

In research involving genetically modified mice which is usually to perform genotyping using invasive ear or tail biopsies in 92% of cases, there is a growing shift towards non-invasive sampling techniques such as oral swabs, hair, faeces and tears. Our...

Year Published: 2024Topics: Biological Sampling & Physiological Measurement, Identification MethodAnimal Type: Mouse, Rabbit, Rodent

Citation: Thasian-Sivarajah, S., Mohr, R., Walter, M. et al. 2024. Non-invasive sampling methods for genotyping: Improvements towards the 4r principle. Animal Technology and Welfare 23(2), 133–136.

Testing perioperative meloxicam analgesia to enhance welfare while preserving model validity in an inflammation-induced seizure model

Despite the international effort to improve laboratory animal welfare through the 3R principles (Reduce, Refine, Replace), many scientists still fail to implement and report their assessment of pain and well-being, likely due to concerns regarding the potential effects of analgesics...

Year Published: 2024Topics: Analgesia, Disease/Experimental Model, Surgery & Post-OpAnimal Type: Mouse, Rodent

Citation: Weiß, E., Pauletti, A., Egilmez, A. et al. 2024. Testing perioperative meloxicam analgesia to enhance welfare while preserving model validity in an inflammation-induced seizure model. Scientific Reports 14(1), 30563.

A new approach (CSA-Score) to assessing the cumulative overall stress load in the case of animal experiments and even beyond

In laboratory animal science, severity assessment has been mandatory by European law since 2013. Various severity assessments have been created for many single manipulations. However, when multiple harmful interventions or stressors occur simultaneously or repeatedly, the cumulative overall severity is...

Year Published: 2024Topics: Welfare AssessmentAnimal Type: All/General, Mouse, Pig, Rodent

Citation: Helmig, S., Wenzel, S. 2024. A new approach (CSA-Score) to assessing the cumulative overall stress load in the case of animal experiments and even beyond. Discover Animals 1(1), 38.

A Retrospective Report of Carprofen Administration as Post-Operative Analgesia Reveals Negative Effects of Recommended Doses

Effective pain management in laboratory animals is crucial for both animal welfare and the reliability of scientific research. We retrospectively examined the effects of carprofen as post-operative analgesia in Sprague Dawley rats following stereotactic surgery. Our data indicate that administering...

Year Published: 2024Topics: AnalgesiaAnimal Type: Rat, Rodent

Citation: Jäckel, Z., Adžemović, A., Kloos, B. et al. 2024. A Retrospective Report of Carprofen Administration as Post-Operative Analgesia Reveals Negative Effects of Recommended Doses. Animals 14(21), 3157.

Ultrasound to ultrasee—The use of ultrasound to determine pregnancy in mice

Several MRC Laboratory of Molecular Biology (LMB) groups require early-stage mouse embryos for their scientific research programmes. Traditionally, Animal Technicians have relied on visual checks or palpation of the abdomen to determine pregnancy in mice. In 2017 an ultrasound machine...

Year Published: 2024Topics: Imaging & Electrophysiological Recording, ReproductionAnimal Type: Mouse, Rodent

Citation: Karam, C., Kemp, K. 2024. Ultrasound to ultrasee—The use of ultrasound to determine pregnancy in mice. Animal Technology and Welfare 23(2), 121–127.

Do we still need a canary in the coal mine for laboratory animal facilities? A systematic review of environmental health monitoring versus soiled bedding sentinels

Introduction Despite increasing evidence that Environmental Health Monitoring (EHM) is an effective method to perform rodent colony health surveillance, promotes the 3Rs as a Replacement, is comparable or reduces cost, and demonstrates labor benefits, many research institutions continue to use...

Year Published: 2024Topics: Husbandry & Management, Welfare AssessmentAnimal Type: Mouse, Rat, Rodent

Citation: LaFollette, M. R., Clement, C. S., Luchins, K. R. et al. 2024. Do we still need a canary in the coal mine for laboratory animal facilities? A systematic review of environmental health monitoring versus soiled bedding sentinels. PLOS ONE 19(12), e0311840.

Rat tickling in gestation females

It has previously not been recommended to perform rat tickling on pregnant females. We questioned if rat tickling could be used for pregnant females to improve their welfare. After discussion with our veterinarians, Named Animal Care and Welfare Officer, and...

Year Published: 2024Topics: Human-Animal Interaction, ReproductionAnimal Type: Rat, Rodent

Citation: Lomax, A., Lurkins, D., Hornsey, H. 2024. Rat tickling in gestation females. Animal Technology and Welfare 23(2), 143–144.

Effects of short-term isolation on social behaviors in prairie voles

Social isolation affects the brain and behavior in a variety of animals, including humans. Studies in traditional laboratory rodents, including mice and rats, have supported the idea that short-term social isolation promotes affiliative social behaviors, while long-term isolation promotes anti-social...

Year Published: 2024Topics: Social Housing & CompanionshipAnimal Type: Other Rodent, Rodent

Citation: Madrid, J. E., Pranic, N. M., Chu, S. et al. 2024. Effects of short-term isolation on social behaviors in prairie voles. PLOS ONE 19(11), e0313172.

The 3Hs Initiative—Housing, handling, and habituation

We have looked at our housing, handling and habituation approaches to identify areas to make improvements. This is critical for our resaerch outputs and has the benefit of reducing the cumulative suffering the animals experience by reducing stress and negative...

Year Published: 2024Topics: Animal Training, Drug/Substance Administration, Handling, Housing, RestraintAnimal Type: Mouse, Rat, Rodent

Citation: Bartlett, J., Hinchcliffe, J., Jackson, M. et al. 2024. The 3Hs Initiative—Housing, handling, and habituation. Animal Technology and Welfare 23(2), 91–99.

Social contagion of pain and fear results in opposite social behaviors in rodents: Meta- analysis of experimental studies

The study aimed to explore the key factors influencing emotional valence in rodents, focusing on the critical elements that distinguish the contagion processes of fear and pain.MethodsThrough a systematic review and meta-analysis, we examined behavioral outcomes of rodents exposed to...

Year Published: 2024Topics: Emotion, Pain, & Sentience, Social Housing & CompanionshipAnimal Type: Mouse, Rat, Rodent

Citation: Du, R., Yu, Y., Wang, X.-L. et al. 2024. Social contagion of pain and fear results in opposite social behaviors in rodents: Meta- analysis of experimental studies. Frontiers in Behavioral Neuroscience 18.