Rodent

Are 50-khz calls used as play signals in the playful interactions of rats? III

When playing, rats emit 50-kHz calls which may function as play signals. A previous study using devocalized rats provides support for the hypothesis that 50-kHz function to promote and maintain playful interactions (Kisko et al., 2015). However, in that study,...

Year Published: 2015Topics: Natural Behavior, VocalizationAnimal Type: Rat, Rodent

Citation: Kisko, T. M., Euston, D. R., Pellis, S. M. 2015. Are 50-khz calls used as play signals in the playful interactions of rats? III. The effects of devocalization on play with unfamiliar partners as juveniles and as adults. Behavioural Processes 113, 113-121.

Effect of multilevel laboratory rat caging system on the well-being of the singly-housed Sprague Dawley rat

Current regulations emphasize that good husbandry practices allow animals to engage in species appropriate postural adjustments without touching the enclosure walls. This study evaluated the well-being of rats housed in a commercially available multilevel rat caging system, with or without...

Year Published: 2015Topics: HousingAnimal Type: Rat, Rodent

Citation: Wheeler, R. R., Swan, M. P., Hickman, D. L. 2015. Effect of multilevel laboratory rat caging system on the well-being of the singly-housed Sprague Dawley rat. Laboratory Animals 49(1), 10-19.

Aspen shaving versus chip bedding: Effects on breeding and behavior

The choice of laboratory cage bedding material is often based on both practical and husbandry issues, whereas behavioral outcomes rarely appear to be considered. It has been noted that a breeding success difference appears to be associated with the differential...

Year Published: 2015Topics: Husbandry & Management, ReproductionAnimal Type: Mouse, Rodent

Citation: Jackson, E., Demarest, K., Eckert, W. J. et al. 2015. Aspen shaving versus chip bedding: Effects on breeding and behavior. Laboratory Animals 49(1), 46-56.

The effect of isoflurane anaesthesia and buprenorphine on the mouse grimace scale and behaviour in CBA and DBA/2 mice

Prevention or alleviation of pain in laboratory mice is a fundamental requirement of in vivoresearch. The mouse grimace scale (MGS) has the potential to be an effective and rapid means of assessing pain and analgesic efficacy in laboratory mice. Preliminary...

Year Published: 2015Topics: Analgesia, Anesthesia & Sedation, Welfare AssessmentAnimal Type: Mouse, Rodent

Citation: Miller, A., Kitson, G., Skalkoyannis, B. et al. 2015. The effect of isoflurane anaesthesia and buprenorphine on the mouse grimace scale and behaviour in CBA and DBA/2 mice. Applied Animal Behaviour Science 172, 58-62.

Effect of cage space on behavior and reproduction in CRl:CD(SD) and BN/Crl laboratory rats

The 2011 Guide for the Care and Use of Laboratory Animals contains recommendations regarding the amount of cage space for mothers with litters. Literature on cage-space use in breeding rats is sparse. We hypothesized that, if present, differences in behavior...

Year Published: 2015Topics: Housing, ReproductionAnimal Type: Rat, Rodent

Citation: Gaskill, B. N., Pritchett-Corning, K. R. 2015. Effect of cage space on behavior and reproduction in CRl:CD(SD) and BN/Crl laboratory rats. JAALAS 54(5), 497-506.

Long-term provision of environmental resources alters behavior but not physiology or neuroanatomy of male and female BALB/c and C57BL/6 mice

Few studies have evaluated the long-term effects of providing environmental resources to mice. This consideration is important given that mice are often maintained in vivaria for months. We evaluated the effects of providing simple cage resources (wood wool, cotton nesting...

Year Published: 2015Topics: Environmental Enrichment, Social Housing & CompanionshipAnimal Type: Mouse, Rodent

Citation: Clipperton-Allen, A. E., Ingrao, J. C., Ruggerio, L. et al. 2015. Long-term provision of environmental resources alters behavior but not physiology or neuroanatomy of male and female BALB/c and C57BL/6 mice. JAALAS 54(6), 718-30.

Effect of enrichment devices on aggression in manipulated nude mice

Agonistic behavior in group-housed male mice is a recurring problem in many animal research facilities. Common management procedures, such as the removal of aggressors, are moderately successful but often fail, owing to recurrence of aggressive behavior among cagemates. Studies have...

Year Published: 2015Topics: Environmental Enrichment, Husbandry & ManagementAnimal Type: Mouse, Rodent

Citation: Lockworth, C. R., Kim, S., Liu, J. et al. 2015. Effect of enrichment devices on aggression in manipulated nude mice. JAALAS 54(6), 731-736.

Strain differences in temporal changes of nesting behaviors in C57BL/6N, DBA/2N, and their F1 hybrid mice assessed by a three-dimensional monitoring system

Nest building is one of the innate behaviors that are widely observed throughout the animal kingdom. Previous studies have reported specific brain regions and genetic loci associated with nest building in mice. These studies mainly evaluated the nest structure, without...

Year Published: 2015Topics: Environmental Enrichment, Natural BehaviorAnimal Type: Mouse, Rodent

Citation: Goto, T., Okayama, T., Toyoda, A. 2015. Strain differences in temporal changes of nesting behaviors in C57BL/6N, DBA/2N, and their F1 hybrid mice assessed by a three-dimensional monitoring system. Behavioural Processes 119, 86-92.

Using dried blood spot sampling to improve data quality and reduce animal use in mouse pharmacokinetic studies

Traditional pharmacokinetic analysis in nonclinical studies is based on the concentration of a test compound in plasma and requires approximately 100 to 200 μL blood collected per time point. However, the total blood volume of mice limits the number of...

Year Published: 2015Topics: Biological Sampling & Physiological MeasurementAnimal Type: Mouse, Rodent

Citation: Wickremsinhe, E. R., Perkins, E. J. 2015. Using dried blood spot sampling to improve data quality and reduce animal use in mouse pharmacokinetic studies. JAALAS. 54(2), 139-144.

Miniaturized blood sampling techniques to benefit reduction in mice and refinement in nonhuman primates: Application to bioanalysis in toxicity studies with antibody-drug conjugates

Minimizing the number of animals in regulatory toxicity studies while achieving study objectives to support the development of future medicines contributes to good scientific and ethical practices. Recent advances in technology have enabled the development of miniaturized blood sampling methods...

Year Published: 2015Topics: Biological Sampling & Physiological MeasurementAnimal Type: Baboon, Capuchin, Chimpanzee, Lemur, Macaque, Marmoset, Mouse, Nonhuman Primate, Other Nonhuman Primate, Owl Monkey, Rodent, Squirrel Monkey, Vervet (African Green Monkey)

Citation: Caron, A., Lelong, C., Pascual, M. H. et al. 2015. Miniaturized blood sampling techniques to benefit reduction in mice and refinement in nonhuman primates: Application to bioanalysis in toxicity studies with antibody-drug conjugates. JAALAS 54(2), 145-152.