Rat

Is that a rat in your pocket? A novel pocket method for rat restraint

At the University of Illinois at Urbana- Champaign (UIUC), we routinely teach novice research personnel how to appropriately handle, restrain, and perform basic experimental techniques on rats. Barriers to teaching include fear of animal bites to the handler, stress to...

Year Published: 2020Topics: RestraintAnimal Type: Rat, Rodent

Citation: Ludwig, J. L. 2020. Is that a rat in your pocket? A novel pocket method for rat restraint. Laboratory Animal Science Professional 8(1) (January/February), 48-49.

Isoflurane and carbon dioxide elicit similar behavioral responses in rats

Euthanasia in rodents is an ongoing topic of debate due to concerns regarding the aversive nature of gases with anesthetic properties such as carbon dioxide (CO2) and isoflurane. The aim of this study was to expand upon previously published work...

Year Published: 2020Topics: EuthanasiaAnimal Type: Rat, Rodent

Citation: Kulkarni, S., Hickman, D. 2020. Isoflurane and carbon dioxide elicit similar behavioral responses in rats. Animals 10(8), 1431.

It’s Okay to Cry – Discussions by the Laboratory Animal Refinement & Enrichment Forum [LAREF], Volume V

This is the 5th volume of selected discussions that took place on the electronic Laboratory Animal Refinement & Enrichment Forum between February 2016 and December 2019. The forum was created in October 2002; it allows the international animal care community...

Year Published: 2020Topics: Abnormal/Problematic Behavior, Animal Training, Biological Sampling & Physiological Measurement, Drug/Substance Administration, Environmental Enrichment, External Bodily Equipment, Housing, Human-Animal Interaction, Relocation & TransportAnimal Type: Cat, Chinchilla, Dog, Ferret, Guinea Pig, Macaque, Marmoset, Mouse, Nonhuman Primate, Pig, Rabbit, Rat, Rodent

Citation: Reinhardt, V. (ed.) 2020. It’s Okay to Cry - Discussions by the Laboratory Animal Refinement & Enrichment Forum [LAREF], Volume V. Animal Welfare Institute, Washington, DC.

Just hanging out: Elevating rat enrichment in small spaces

This article describes how an Animal Care Technician at Mayo Clinic Rochester campus designed and created a novel enrichment item for rats: a ‘hammock’ made of PVC tunnels hung onto the lid of standard laboratory rat cages.

Year Published: 2020Topics: Environmental EnrichmentAnimal Type: Rat, Rodent

Citation: Brekke, J., Scholz, J. 2020. Just hanging out: Elevating rat enrichment in small spaces. Laboratory Animal Science Professional 8(3) (May/June), 40-42.

Protection of blood-brain barrier as a potential mechanism for enriched environments to improve cognitive impairment caused by chronic cerebral hypoperfusion

Chronic cerebral hypoperfusion (CCH) is a common pathophysiological basis for Alzheimer’s Disease and vascular dementia in the early stages. It has been confirmed that blood-brain barrier (BBB) destruction is a key factor in CCH-related cognitive impairment. Here we explored the...

Year Published: 2020Topics: Environmental EnrichmentAnimal Type: Rat, Rodent

Citation: Qu, C., Xu, L., Shen, J. et al. 2020. Protection of blood-brain barrier as a potential mechanism for enriched environments to improve cognitive impairment caused by chronic cerebral hypoperfusion. Behavioural Brain Research 379, 112385.

Maternal deprivation impairs memory and cognitive flexibility, effect that is avoided by environmental enrichment

Maternal deprivation (MD) causes cognitive deficits that persist until adulthood. Thereby, the environmental enrichment (EE) is widely used to increase brain plasticity. Here, pregnant female rats were used and their offspring were submitted to neonatal MD from post-natal day 1–10;...

Year Published: 2020Topics: Environmental EnrichmentAnimal Type: Rat, Rodent

Citation: Menezes, J., Souto das Neves, B.-H., Gonçalves, R. et al. 2020. Maternal deprivation impairs memory and cognitive flexibility, effect that is avoided by environmental enrichment. Behavioural Brain Research 381, 112468.

Nesting material enrichment reduces severity of overgrooming-related self-injury in individually housed rats

Individual or singly-housing laboratory rats is common in many animal facilities, but has an adverse impact on the welfare of this social species. It has previously been shown that a small proportion of individually housed mice (∼5%) engage in pathological...

Year Published: 2020Topics: Environmental EnrichmentAnimal Type: Rat, Rodent

Citation: Khoo, S. Y.-S., Correia, V., Uhrig, A. 2020. Nesting material enrichment reduces severity of overgrooming-related self-injury in individually housed rats. Laboratory Animals 54(6), 546-558.

Individually ventilated cages severely attenuate inter-cage ultrasonic vocalizations in rats

Individually ventilated cages (IVCs) benefit rodent and researcher health but may limit animals’ ability to communicate with cage-neighbours via ultrasonic vocalizations (USVs). Despite USVs’ importance in rodent social behaviour, no previous research has investigated IVCs’ impact on between-cage USV transmission....

Year Published: 2025Topics: Housing, VocalizationAnimal Type: Rat, Rodent

Citation: Scott, K. J., Bilkey, D. K. 2025. Individually ventilated cages severely attenuate inter-cage ultrasonic vocalizations in rats. Journal of Applied Animal Welfare Science 28(4), 730–739.

Effects of dietary restriction on regulation of energy metabolism in male Wistar rats (Rattus norvegicus)

Laboratory rats are most often fed ad libitum (AL), but dietary restriction (DR) is commonly used to provide appropriate experimental designs. The current methods of DR have shortcomings; animals are often subjected to social isolation, periods of fasting, and disturbed...

Year Published: 2025Topics: Husbandry & ManagementAnimal Type: Rat, Rodent

Citation: Kasanen, I. H. E., Inhilä, K. J., Nevalainen, T. O. et al. 2025. Effects of dietary restriction on regulation of energy metabolism in male Wistar rats (Rattus norvegicus). JAALAS 64(4), 744–749.

Behavioral assessment of tramadol and meloxicam effects on postoperative pain in a rat craniotomy model

Stereotaxic surgery is a common procedure in neuroscience, yet effective analgesic protocols require further study and refinement to optimize the analgesia used in invasive procedures and to improve animal welfare. This study evaluated the effects of tramadol and meloxicam, alone...

Year Published: 2025Topics: Analgesia, Disease/Experimental ModelAnimal Type: Rat, Rodent

Citation: Alemán-Laporte, J., Alvarado, G., Pellagio, N. B. et al. 2025. Behavioral assessment of tramadol and meloxicam effects on postoperative pain in a rat craniotomy model. JAALAS 64(4), 716–725.