Rat

Pavlovian influences on learning differ between rats and mice in a counterbalanced Go/NoGo judgement bias task

Judgement bias tests of animal affect and hence welfare assume that the animal's responses to ambiguous stimuli, which may herald positive or negative outcomes, are under instrumental control and reflect ‘optimism' or ‘pessimism' about what will happen. However, Pavlovian control...

Year Published: 2017Topics: Welfare AssessmentAnimal Type: Mouse, Rat, Rodent

Citation: Jones, S., Paul, E. S., Dayan, P. et al. 2017. Pavlovian influences on learning differ between rats and mice in a counterbalanced Go/NoGo judgement bias task. Behavioural Brain Research 331, 214-224.

Ethological approach to social isolation effects in behavioral studies of laboratory rodents

The aim of the present review is to discuss how housing conditions affect behavioral performance in laboratory rodents from an ethological view. Commonly used laboratory rodents such as rats and mice, are originally captured animals that largely retain species-typical natural...

Year Published: 2018Topics: Social Housing & CompanionshipAnimal Type: Mouse, Rat, Rodent

Citation: Arakawa, H. 2018. Ethological approach to social isolation effects in behavioral studies of laboratory rodents. Behavioural Brain Research 341, 98-108.

Rat aversion to isoflurane versus carbon dioxide

Some experts suggest that sedation of laboratory rodents with isoflurane before euthanasia with carbon dioxide (CO2) is a humane alternative to euthanasia with CO2 alone, but little research has compared aversion with these agents. Albino rats were tested in a...

Year Published: 2013Topics: EuthanasiaAnimal Type: Rat, Rodent

Citation: Wong, D., Makowska, I. J., Weary, D. M. 2013. Rat aversion to isoflurane versus carbon dioxide. Biology Letters 9(1), 20121000.

Environmental enrichment in the absence of wheel running produces beneficial behavioural and anti-oxidative effects in rats

The effects of early environmental enrichment (EE) when solving a simple spatial task in adult male rats were assessed. After weaning, rats were housed in pairs in enriched or standard cages (EE and control groups) for two and a half...

Year Published: 2017Topics: Environmental EnrichmentAnimal Type: Rat, Rodent

Citation: Mármol, F., Sánchez, J., Torres, M. N. et al. 2017. Environmental enrichment in the absence of wheel running produces beneficial behavioural and anti-oxidative effects in rats. Behavioural Processes 144, 66-71.

Advances in animal welfare and scientific outcomes of the bile duct cannulated rat model utilised in ADME studies

Since rats lack a gall bladder, they are an ideal model for investigating continuous biliary excretion and biotransformation. The design and implementation of a modified tail cuff and cannula system introduced at Covance permits the animal's own bile to be...

Year Published: 2018Topics: Cannulation, Catheterization, & Intubation, Social Housing & CompanionshipAnimal Type: Rat, Rodent

Citation: van Wijk, H., Crossman, L., Adjin-Tettey, G. et al. 2018. Advances in animal welfare and scientific outcomes of the bile duct cannulated rat model utilised in ADME studies. Animal Technology and Welfare 17(1), 64-67.

Investigation of transportation on rat acclimatisation using novel cage side recording equipment (Rodent Big Brother)

The transportation of animals from supplier to experimental facility is one of the biggest stressors to animals in research. Transportation unavoidably causes stress and when the animals arrive at the testing facility they require a period of acclimatisation, which is...

Year Published: 2017Topics: Relocation & TransportAnimal Type: Rat, Rodent

Citation: Simpson, D. 2017. Investigation of transportation on rat acclimatisation using novel cage side recording equipment (Rodent Big Brother). Animal Technology and Welfare 16(1), 1-12.

Effect of moderate environmental enrichment on commonly used behavioural tests in rats

The environment that laboratory animals are housed in should reflect their natural habitats in a manner that can satisfy their innate physiological and behavioural needs. This includes nest building, hiding, exploring and foraging. Providing environmental enrichment (EE) in order to...

Year Published: 2017Topics: Emotion, Pain, & Sentience, Environmental EnrichmentAnimal Type: Rat, Rodent

Citation: Kleefeld, S., Bannerton, K., Kelly, J.2017. Effect of moderate environmental enrichment on commonly used behavioural tests in rats. Animal Technology and Welfare 16(1), 75-76.

Report of the 2016 RSPCA/UFAW Rodent and Rabbit Welfare Group meeting

The RSPCA/UFAW Rodent (and now Rabbit) Welfare Group held a one-day meeting on 1 November 2016 at the University of Edinburgh and was attended by 70 delegates. Presentation topics included refinements in blood sampling rodents, reducing suffering in projects involving...

Year Published: 2017Topics: Biological Sampling & Physiological Measurement, Disease/Experimental Model, Husbandry & Management, Welfare AssessmentAnimal Type: Mouse, Rabbit, Rat, Rodent

Citation: Hawkins, P., McNeilly, A., Watson, J. et al. 2017. Report of the 2016 RSPCA/UFAW Rodent and Rabbit Welfare Group meeting. Animal Technology and Welfare 16(2), 77-86.

Ultrasonic vocalisation as a measure of positive welfare in rats

Studies of animal welfare in laboratory animals have historically relied on the measurement of negative indicators rather than the assessment of positive indicators of welfare. Practical methods of welfare assessment are required to allow refinement of housing and experimental protocols....

Year Published: 2017Topics: Environmental Enrichment, Housing, VocalizationAnimal Type: Rat, Rodent

Citation: Jones, T., Robinson, M., Leach, M. et al. 2017. Ultrasonic vocalisation as a measure of positive welfare in rats. Animal Technology and Welfare 16(2), 127-129.

A refinement to Schedule 1

There are varying methods used for animal restraint and angle of injection. It remains unclear whether one method is more accurate than others. The primary objectives were to examine whether inverted restraint of rats resulted in more effective outcomes and...

Year Published: 2018Topics: Drug/Substance AdministrationAnimal Type: Rat, Rodent

Citation: Read, H., Perry, R. 2018. A refinement to Schedule 1. Animal Technology and Welfare 17(2), 117-120.