Rat

Immunomodulatory effects of stress and environmental enrichment in Long–Evans rats (Rattus norvegicus)

Stress can influence the secretion of neuroendocrine mediators, thereby exposing immune cells to altered signaling and interactions. Here we investigated the synergetic effect of stress and environmental enrichment on the immune response of Long–Evans rats. Subjects (n = 46) were...

Year Published: 2019Topics: Environmental EnrichmentAnimal Type: Rat, Rodent

Citation: Scarola, S. J., Perdomo Trejo, J. R., Granger, M. E. et al. 2019. Immunomodulatory effects of stress and environmental enrichment in Long–Evans rats (Rattus norvegicus). Comparative Medicine 69(1), 35–47.

Comparison of isoflurane, ketamine-dexmedetomidine, and ketamine-xylazine for general anesthesia during oral procedures in rice rats (Oryzomys palustris)

Rice rats (Oryzomys palustris) are an unconventional laboratory species that has been used to study photoperiodicity, periodontitis, and osteonecrosis of the jaw. Interventional procedures that require anesthesia, including oral procedures, are sometimes necessary in preclinical settings. The use of anesthetics...

Year Published: 2019Topics: Anesthesia & Sedation, Disease/Experimental ModelAnimal Type: Rat, Rodent

Citation: Jiron, J. M., Mendieta Calle, J. L., Castillo, E. J. et al. 2019. Comparison of isoflurane, ketamine-dexmedetomidine, and ketamine-xylazine for general anesthesia during oral procedures in rice rats (Oryzomys palustris). JAALAS 58(1), 40-49.

Effects of rodent thermoregulation on animal models in the research environment

To best promote animal wellbeing and the efficacy of biomedical models, scientific, husbandry, and veterinary professionals must consider the mechanisms, influences, and outcomes of rodent thermoregulation in contemporary research environments. Over the last 2 decades, numerous studies have shown that...

Year Published: 2018Topics: Anesthesia & Sedation, Environmental EnrichmentAnimal Type: Mouse, Rat, Rodent

Citation: Hankenson, F. C., Marx, J. O., Gordon, C. J. et al. 2018. Effects of rodent thermoregulation on animal models in the research environment. Comparative Medicine 68(6), 425–438.

The effects of environmental enrichment and social isolation and their reversion on anxiety and fear conditioning

Animal models of fear and anxiety provide important insight into anxiety-related symptoms in humans. Environmental physical conditions and social contact influence behavior and brain plasticity particularly at early developmental stages and have long lasting effects reaching even adulthood. The potential...

Year Published: 2019Topics: Environmental EnrichmentAnimal Type: Rat, Rodent

Citation: Mora-Gallegos, A., Fornaguera, J. 2019. The effects of environmental enrichment and social isolation and their reversion on anxiety and fear conditioning. Behavioural Processes 158, 59-69.

The impact of changeability of enriched environment on exploration in rats

Although the positive effect of environmental enrichment on animals' cognitive capacities is well-known, it remains unclear what role changeability plays in this context. Our study aims to analyse the impact of environmental changeability on the level of exploration and the...

Year Published: 2019Topics: Environmental EnrichmentAnimal Type: Rat, Rodent

Citation: Modlinska, K., Chrzanowska, A., Pisula, W. 2019. The impact of changeability of enriched environment on exploration in rats. Behavioural Processes 164, 78-85.

Returning to home cage serves as an effective reward for maze learning in rats

This study examined the effectiveness in rats of ‘returning to home cage' as a reward for learning a Lashley III maze. Rats could return to their home cage directly (Direct HC group) or they could be removed manually by an...

Year Published: 2019Topics: Animal TrainingAnimal Type: Rat, Rodent

Citation: Taniuchi, T., Ohgi, A., Nishikawa, M. 2019. Returning to home cage serves as an effective reward for maze learning in rats. Behavioural Processes 164, 175-177.

Effects of combined pre- and post-natal enrichment on anxiety-like, social, and cognitive behaviours in juvenile and adult rat offspring

The pre- and post-natal periods are characterized by unrivalled growth and are sensitive to environmental changes. A correctly stimulating early environment is essential for developing natural behaviors and maintaining affective wellness. Five litters of rat progeny were co-housed through gestation...

Year Published: 2018Topics: Environmental EnrichmentAnimal Type: Rat, Rodent

Citation: Sparling, J. E., Baker, S. L., Bielajew, C. 2018. Effects of combined pre- and post-natal enrichment on anxiety-like, social, and cognitive behaviours in juvenile and adult rat offspring. Behavioural Brain Research 353, 40-50.

Emission of 22 kHz vocalizations in rats as an evolutionary equivalent of human crying: Relationship to depression

There is no clear relationship between crying and depression based on human neuropsychiatric observations. This situation originates from lack of suitable animal models of human crying. In the present article, an attempt will be made to answer the question whether...

Year Published: 2019Topics: Emotion, Pain, & Sentience, VocalizationAnimal Type: Rat, Rodent

Citation: Brudzynski, S. M. 2019. Emission of 22 kHz vocalizations in rats as an evolutionary equivalent of human crying: Relationship to depression. Behavioural Brain Research 363, 1-12.

Distinct environmental enrichment protocols reduce anxiety but differentially modulate pain sensitivity in rats

Environmental enrichment (EE) can alter anxiety as well as perception of nociceptive stimuli, suggesting a relationship between well-being and analgesia. Considering that, we aimed to evaluate the influence of different EE types on anxiety and peripheral pain sensitivity of male...

Year Published: 2019Topics: Environmental EnrichmentAnimal Type: Rat, Rodent

Citation: Faggionato Kimura, L., Mattaraia, V. G. M., Picolo, G. 2019. Distinct environmental enrichment protocols reduce anxiety but differentially modulate pain sensitivity in rats. Behavioural Brain Research 364, 442-446.

Music exposure attenuates anxiety- and depression-like behaviors and increases hippocampal spine density in male rats

Epidemiological and clinical studies suggest that early-life stress (ELS) may lead to the development of mental disorders in adulthood. Maternal separation (MS) is a valid animal model of ELS that produces detrimental effects on brain and behavior of experimental animals....

Year Published: 2019Topics: Environmental EnrichmentAnimal Type: Rat, Rodent

Citation: Papadakakis, A., Sidiropoulou, K., Panagis, G. 2019. Music exposure attenuates anxiety- and depression-like behaviors and increases hippocampal spine density in male rats. Behavioural Brain Research 372, 112023.