Mouse

Partial cage division significantly reduces aggressive behavior in male laboratory mice

Aggression in mice often results in injury leading to unplanned euthanasia or the initiation of protocols to isolate animals, thereby increasing research costs and straining resources. Here, we tested if adding a partial cage divider into existing mouse cages affected...

Year Published: 2018Topics: Environmental Enrichment, HousingAnimal Type: Mouse, Rodent

Citation: Tallent, B. R., Law, L. M., Rowe, R. K. et al. 2018. Partial cage division significantly reduces aggressive behavior in male laboratory mice. Laboratory Animals 52(4), 384 - 393.

A refined and translationally relevant model of chronic DSS colitis in BALB/c mice

Inflammatory bowel diseases (IBD) are chronic relapsing disorders of the gastrointestinal tract. Several mouse models for IBD are available, but the acute dextran sulfate sodium (DSS)-induced colitis model is mostly used for preclinical studies. However, this model lacks chronicity and...

Year Published: 2018Topics: Disease/Experimental ModelAnimal Type: Mouse, Rodent

Citation: Hoffmann, M., Schwertassek, U., Seydel, A. et al. 2018. A refined and translationally relevant model of chronic DSS colitis in BALB/c mice. Laboratory Animals 52(3), 240-252.

A comparison of various methods of blood sampling in mice and rats: Effects on animal welfare

This study was conducted to investigate the effects of blood sampling on animal welfare in a total of 60 NTac:SD rats and 72 C57BL/6NTac mice of both sexes. Blood was sampled either by sublingual vein puncture, tail vein puncture or...

Year Published: 2018Topics: Biological Sampling & Physiological MeasurementAnimal Type: Mouse, Rat, Rodent

Citation: Harikrishnan, V. S., Hansen, A. K., Abelson, K. S. P. et al. 2018. A comparison of various methods of blood sampling in mice and rats: Effects on animal welfare. Laboratory Animals 52(3), 253-264.

Analgesics promote welfare and sustain tumour growth in orthotopic 4T1 and B16 mouse cancer models

Murine orthotopic cancer models often require surgery, potentially causing pain or distress. However, analgesics are often withheld because they may alter tumour development. Two orthotopically implanted cancers were investigated in mice pre-treated with meloxicam (10 mg/kg), buprenorphine (0.2 mg/kg) or...

Year Published: 2018Topics: AnalgesiaAnimal Type: Mouse, Rodent

Citation: Lofgren, J., Miller, A. L., Shan Lee, C. C. et al. 2018. Analgesics promote welfare and sustain tumour growth in orthotopic 4T1 and B16 mouse cancer models. Laboratory Animals 52(4), 351-364.

Hang on: An evaluation of the hemp rope as environmental enrichment in C57BL/6 mice

When introducing environmental enrichment in laboratory animals, positive and/or negative effects on behavioural and physiological parameters should be evaluated. This three-step randomised controlled trial in male C57BL/6 mice investigated the effect of supplementing the environment with one or more hemp...

Year Published: 2017Topics: Environmental EnrichmentAnimal Type: Mouse, Rodent

Citation: Gjendal, K., Sørensen, D. B., Kiersgaard, M. K. et al. 2017. Hang on: An evaluation of the hemp rope as environmental enrichment in C57BL/6 mice. Animal Welfare 26(4), 437-447.

Epileptiform activity during inert gas euthanasia of mice

Carbon dioxide (CO2) is one of the most commonly used euthanasia agents for mice, yet it is highly aversive and nociceptive. Inert gases are a possible alternative, however there are qualitative reports of seizures resulting from exposure. Here we evaluate...

Year Published: 2018Topics: EuthanasiaAnimal Type: Mouse, Rodent

Citation: Gent, T. C., Detotto, C., Vyssotski, A. L. et al. 2018. Epileptiform activity during inert gas euthanasia of mice. PLOS ONE 13(4), e0195872.

Enriched environment and stress exposure influence splenic B lymphocyte composition

Prolonged chronic stress has deleterious effects on immune function and is associated with numerous negative health outcomes. The spleen harbors one-fourth of the body's lymphocytes and mediates both innate and adaptive immune responses. However, the subset of splenic lymphocytes that...

Year Published: 2017Topics: Environmental EnrichmentAnimal Type: Mouse, Rodent

Citation: Gurfein, B. T., Hasdemir, B., Milush, J. M. et al. 2017. Enriched environment and stress exposure influence splenic B lymphocyte composition. PLOS ONE 12(7), e0180771.

Severity classification of repeated isoflurane anesthesia in C57BL/6JRj mice—Assessing the degree of distress

According to the EU Directive 2010/63, the severity of a procedure has to be classified as mild, moderate or severe. General anesthesia is thought to be mild, but the Directive does not differentiate between single and repeated anesthesia. Therefore, we...

Year Published: 2017Topics: Anesthesia & SedationAnimal Type: Mouse, Rodent

Citation: Hohlbaum, K., Bert, B., Dietze, S. et al. 2017. Severity classification of repeated isoflurane anesthesia in C57BL/6JRj mice—Assessing the degree of distress. PLOS ONE 12(6), e0179588.

Fancy Mice, Fifth Edition

Adult males, on the other hand, must be housed separately, for, if put together, they will fight to the death. As already mentioned, young males of the same litter if never separated from birth may live together for some time,...

Year Published: 1912Animal Type: Mouse, Rodent

Citation: Davies, C. J. 1912. Fancy Mice, Fifth Edition. L Upcott Gill, London, UK.

Effect of cage-induced stereotypies on measures of affective state and recurrent perseveration in CD-1 and C57BL/6 mice

Stereotypies are abnormal repetitive behaviour patterns that are highly prevalent in laboratory mice and are thought to reflect impaired welfare. Thus, they are associated with impaired behavioural inhibition and may also reflect negative affective states. However, in mice the relationship...

Year Published: 2016Topics: Abnormal/Problematic BehaviorAnimal Type: Mouse, Rodent

Citation: Novak, J., Bailoo, J. D., Melotti, L. et al. 2016. Effect of cage-induced stereotypies on measures of affective state and recurrent perseveration in CD-1 and C57BL/6 mice. PLOS ONE 11(5), e0153203.